DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dctn1 and DCTN1-p150

DIOPT Version :9

Sequence 1:	NP_077044.2	Gene:	Dctn1 / 29167	RGDID:	62038	Length:	1281	Species:	Rattus norvegicus
Sequence 2:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	1281	Identity:	432/1281 - (33%)
Similarity:	690/1281 - (53%)	Gaps:	98/1281 - (7%)

- Green bases have known domain annotations that are detailed below.

  Rat    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87
            |.:.|:||:|||:.||...|||||||.|.||.||||||:|||.||||.|:::|::||.|||..|:
  Fly     2 SEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGM 66

  Rat    88 FVRQSQIQVFEDGADTTSPETPDSSASKILKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKP 152
            |||.:|:::.| .|..:.....|.|.:.....:...|...:|:......:::....:|.......
  Fly    67 FVRPTQLRLLE-AAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLS 130

  Rat   153 TRPASTGVAGPSSSLGPSGS----------------ASAGELSSSEPS----------------- 184
            .|.||:...||..||.|..|                ||.|..::|..|
  Fly   131 ERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKP 195

  Rat   185 --TPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRSEDKAKLKE 247
              ||:| ||.:|....|:.:.......|....|....|:||:.||.||||||:.:|:|||.:|:|
  Fly   196 QFTPSQ-PLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLRE 259

  Rat   248 LEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 312
            .:|.|||.||:||:::|:...||.||:.|..|::|||:|:||||::.:||||.||.:||.|||||
  Fly   260 FDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKE 324

  Rat   313 MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK-----------GSDGAASSYQLKQLEEQ 366
            ||||:|::||.|:|:.|||::||..|||:|::|::.|           |.....|:|:.||||:|
  Fly   325 MAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQ 389

  Rat   367 NARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431
            |.|||:.|||:||||:.:|.:..||.|.:|.|..|:..:.:.:|:|..::.:.|:.:.:|:||||
  Fly   390 NIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVD 454

  Rat   432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
            ||||||||||.|.::.:.||:||:.|.|.:..|||:.|::::|.|:..|.||:|||:||:|....
  Fly   455 AALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAK 519

  Rat   497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP-----PETFDFK 556
            :|..:..:||.||:.|..|||.|:|:|...|.|...||.::..::.:...|.|     .||.|:|
  Fly   520 KEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYK 584

  Rat   557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAEL 621
            ..|||:||:.:||:::|||:|::|||.|:.:||||||:||:..|||||.:||:||:.|::.|.::
  Fly   585 QMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDI 649

  Rat   622 IRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686
            :..|.:|:|...:..:.....:|.|.:|.:|...|::.:..||..||:..:.|:.|..|...:.|
  Fly   650 VVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAG 714

  Rat   687 SLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA-EQPEESTMQLADHI 750
            |..|||.|.|:.:|.:||||..:||||....:.:.|.:.::..:.|:.|| ||.......:.|.:
  Fly   715 SSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCV 779

  Rat   751 KFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPA 815
            ....:|.:.:..:....:..:|.....:|..||::.|..:...:||..|.|:||:| :|...|.:
  Fly   780 ASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLP-SDQHVIKS 843

  Rat   816 ALAFGSQVSDTLLDCRKHLTWVVAVL-----QEVAAAAAQLIAPLAENEGLPVAALEELAFKASE 875
            .|:  ....:.:....::::.:::.:     |.:||..:.:.:..|....||......|...:.|
  Fly   844 GLS--QHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCE 906

  Rat   876 QIYGSPSSSPYECLRQSCSILISTMNKLATAMQEGEYD----------AERPPSKPPPVELRAAA 930
            :||......|.:..:...:...|.:..:|..:.:.|||          .::..:...|:..||..
  Fly   907 RIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQL 971

  Rat   931 LRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQ 995
            ::.::.....|...||:||..:|:||.:.|:|..||||..:|..|.||||.....:.:..::|.:
  Fly   972 IKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVDKWK 1036

  Rat   996 TRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKTEL--KQRLNSQSKRTIEGLRGPPPSGIAT 1058
            .:.|||...|:.||||||||||.||:|||.||:||::|  |.:|||.:.:...|.....|..|:.
  Fly  1037 QKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNISL 1101

  Rat  1059 LVSGIAGEEQQRGGTPGQAPGA--LPGPGPVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKA 1121
                        .|....|||.  :....|...:|::.:::..::...:|.:::...|:...|:|
  Fly  1102 ------------SGNTSTAPGISNVSYSAPAGTAPVVAEEVELLKNAFNQERNQRLRLQAQDMRA 1154

  Rat  1122 SLAALPPLHVAKFSLPPHEGPGGNLLSGALYRKTSQLLEKLNQLSTHTHVVDITRSSPAAKSPSA 1186
            .|:...||||     |..:......|...|.|.....:..|.|:.:...|...||....|    .
  Fly  1155 KLSQFEPLHV-----PQPQDQRITALESELTRMKHAWVLSLLQVRSQDSVNSGTRIDAVA----L 1210

  Rat  1187 QLMEQVAQLK-SLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPS 1231
            |...|...|| .:|....:|..::|.|.:.::|.......||:||:
  Fly  1211 QRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPT 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dctn1	NP_077044.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/2 (50%)
		CAP_GLY	29..94	CDD:396049	41/64 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..223		30/158 (19%)
		Herpes_BLLF1	<101..>214	CDD:282904	28/147 (19%)
		SMC_prok_B	220..>540	CDD:274008	155/330 (47%)
		Dynactin	527..805	CDD:403600	93/283 (33%)
		Interaction with HPS6. /evidence=ECO:0000250\|UniProtKB:O08788	911..1281		96/336 (29%)
		SMC_prok_A	<924..>1037	CDD:274009	48/114 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1090		5/26 (19%)
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	42/65 (65%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	91/280 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342641
Domainoid	1	1.000	302	1.000	Domainoid score	I1357
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3011
Inparanoid	1	1.050	664	1.000	Inparanoid score	I721
OMA	1	1.010	-	-		QHG53055
OrthoDB	1	1.010	-	-		D1550378at2759
OrthoFinder	1	1.000	-	-		FOG0005456
OrthoInspector	1	1.000	-	-		oto98494
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	LDO	PTHR18916
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810