Protein Alignment GRM6 and grm6a

DIOPT Version :10

• Sequence 1: NP_000834.2
• Gene: GRM6 / 2916
• HGNCID: 4598
• Length: 877
• Species: Homo sapiens
• Sequence 2: XP_021333966.1
• Gene: grm6a / 568484
• ZFINID: ZDB-GENE-060208-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 856
• Identity: 634/856 - (74%)
• Similarity: 726/856 - (84%)
• Gaps: 15/856 - (1%)

Human    18 LAWLAQAGLARAAG--------SVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLY 74
            |.|:....|:..:.        |:::.|.:|||||||||:||.||..||::|||:|:||||||||
Zfish    33 LLWILWVWLSPCSSVHQHSHPHSIKIPGDITLGGLFPVHSRGPAGVPCGEIKKEKGIHRLEAMLY 97

Human    75 ALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRP 139
            |||::|:||||||.:.||||:|||||||||||||:|:||||||:    .|...:||..|..|: .
Zfish    98 ALDQINSDPELLPNITLGARILDTCSRDTYALEQSLTFVQALIQ----KDTSDIRCSNGEQPI-I 157

Human   140 APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAM 204
            ..|||||.|:|||.||||||||||||||.|||||||||||||||:.|||||||||||||||||||
Zfish   158 RKPERVVGVIGASGSSVSIMVANVLRLFEIPQISYASTAPELSDNNRYDFFSRVVPPDSYQAQAM 222

Human   205 VDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269
            ||||:|:|||||||||||||||||||:||||||||.||:|||||:|||||||||||.|:|:||||
Zfish   223 VDIVKAMGWNYVSTLASEGNYGESGVDAFVQISRETGGLCIAQSMKIPREPKPGEFDKIIKRLME 287

Human   270 TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRA 334
            ||||||:||||:||||::||||||::||||||.:|||||||||:||||..||||.||:|||||||
Zfish   288 TPNARGVIIFAHEDDIKQVLEAARRSNLTGHFKFVGSDSWGAKSSPILDQEDVAEGAVTILPKRA 352

Human   335 SIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEG 399
            |||||||||.||||||||||||||||||::|.||||..|.:.|...:||||||||.|||.|||||
Zfish   353 SIDGFDQYFTTRSLENNRRNIWFAEFWEDDFRCKLTRPGIKIDPEKKKCTGEERISRDSHYEQEG 417

Human   400 KVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENG 464
            |||||||||||:|||||:|||.||||.||:|..|:|.:||.||.|||||.|||||||.|:|||||
Zfish   418 KVQFVIDAVYAMAHALHNMHQELCPGATGVCDKMDPVEGRSLLNYIRAVNFNGSAGTAVLFNENG 482

Human   465 DAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKK 529
            ||||||||||||.||  .||.||:.:|||...|||:||.:||:|...::|.|:||.||..|||||
Zfish   483 DAPGRYDIFQYQMTN--TSSPGYRVIGQWTNNLRLNVEEMQWTGGSRQIPDSVCSFPCRSGERKK 545

Human   530 MVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAV 594
            ||||||||||||.||||:||.|||.||.||.|||||.|.|.|||||:::|.|.||||..||.||:
Zfish   546 MVKGVPCCWHCELCDGYQFQADEFNCEMCPFDMRPTLNRTACRPTPIIKLEWHSPWAVIPLFLAI 610

Human   595 LGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGL 659
            |||:||..::.||:|:|:||||||:||||||||||||||||.|||||:||||..|||.|||.|||
Zfish   611 LGILATLFIIITFIRFNDTPIVRAAGRELSYVLLTGIFLIYLITFLMIAEPGTVVCAFRRLLLGL 675

Human   660 GTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSV 724
            |.:::|||:|||||||||||||||:|||||.||||||||:|||.|.|:||||:..|.|..|||:.
Zfish   676 GMSITYSAMLTKTNRIYRIFEQGKKSVTPPKFISPTSQLMITFVLISVQVVGVFVWFGVMPPHTT 740

Human   725 IDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTM 789
            :||||.|..:||.|||:|||||||||||.||.||::|||||||||:|:|||||||||||||||||
Zfish   741 VDYEELRPPNPELARGILKCDMSDLSLICCLSYSIVLMVTCTVYAVKSRGVPETFNEAKPIGFTM 805

Human   790 YTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKR 854
            ||||||||||||||||||||.||::|||||||||:||||||||||||:||.|||:||||||||||
Zfish   806 YTTCIIWLAFVPIFFGTAQSTEKMFIQTTTLTVSMSLSASVSLGMLYIPKVYVIIFHPEQNVQKR 870

Human   855 KRSLKATSTVA 865
            |||.||....|
Zfish   871 KRSFKAVVQAA 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM6	NP_000834.2	PBP1_mGluR_groupIII	45..506	CDD:380599	352/460 (77%)
		NCD3G	514..564	CDD:462210	38/49 (78%)
		7tmC_mGluR6	584..856	CDD:320569	212/271 (78%)
		TM helix 1	584..609	CDD:320569	14/24 (58%)
		TM helix 2	621..642	CDD:320569	19/20 (95%)
		TM helix 3	651..673	CDD:320569	14/21 (67%)
		TM helix 4	699..715	CDD:320569	9/15 (60%)
		TM helix 5	747..770	CDD:320569	18/22 (82%)
		TM helix 6	779..804	CDD:320569	24/24 (100%)
		TM helix 7	814..839	CDD:320569	21/24 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	856..877		5/10 (50%)
grm6a	XP_021333966.1	PBP1_mGluR_groupIII	56..522	CDD:380599	358/472 (76%)
		NCD3G	530..580	CDD:462210	38/49 (78%)
		7tmC_mGluR_group3	600..870	CDD:320413	210/269 (78%)
		TM helix 1	600..625	CDD:320413	14/24 (58%)
		TM helix 2	637..658	CDD:320413	19/20 (95%)
		TM helix 3	667..691	CDD:320413	16/23 (70%)
		TM helix 4	713..733	CDD:320413	12/19 (63%)
		TM helix 5	763..789	CDD:320413	20/25 (80%)
		TM helix 6	797..820	CDD:320413	22/22 (100%)
		TM helix 7	830..855	CDD:320413	21/24 (88%)