Protein Alignment GRM6 and grm6b

DIOPT Version :10

• Sequence 1: NP_000834.2
• Gene: GRM6 / 2916
• HGNCID: 4598
• Length: 877
• Species: Homo sapiens
• Sequence 2: NP_001073489.2
• Gene: grm6b / 565450
• ZFINID: ZDB-GENE-021120-2
• Length: 909
• Species: Danio rerio
• Alignment Length: 869
• Identity: 643/869 - (73%)
• Similarity: 742/869 - (85%)
• Gaps: 16/869 - (1%)

Human     6 RAREPLLVALLPLAWLAQAGL---ARAAG------SVRLAGGLTLGGLFPVHARGAAGRACGQLK 61
            ||.:|.:.:|:.:.|:...|.   ::||.      |:::.|.:|||||||||:||.||..||::|
Zfish    22 RAPKPHVGSLIHIMWILTMGFTPESQAASSDTQPHSIKIEGDITLGGLFPVHSRGPAGIPCGEVK 86

Human    62 KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEV 126
            ||:|:||:||||||||::|:||:|||.:.||||:|||||||||||||:|:||||||:    .|..
Zfish    87 KEKGIHRMEAMLYALDQINSDPDLLPNITLGARILDTCSRDTYALEQSLTFVQALIQ----KDNS 147

Human   127 GVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFS 191
            .|||..|.||:.| .|||||.|:||||||||||||||||||||||||||||||||||:.||||||
Zfish   148 DVRCSNGEPPIIP-KPERVVGVIGASASSVSIMVANVLRLFAIPQISYASTAPELSDNNRYDFFS 211

Human   192 RVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPK 256
            |||||||:|||||||||:|:|||||||||||||||||||:||:||||||||:||||:|||||||:
Zfish   212 RVVPPDSFQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAFIQISREAGGLCIAQAIKIPREPR 276

Human   257 PGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLED 321
            ||||.|:|:|||||.||||:|||||||||:||||||::||||||||:|||||||||.||||:.||
Zfish   277 PGEFDKIIKRLMETSNARGVIIFANEDDIKRVLEAAKRANLTGHFLFVGSDSWGAKISPILNQED 341

Human   322 VAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGE 386
            ||.||:|||||||||:||||||.||||||||||||||||||::|.||||..|.:.|...||||||
Zfish   342 VAEGAVTILPKRASIEGFDQYFTTRSLENNRRNIWFAEFWEDDFKCKLTRPGIRGDGGLRKCTGE 406

Human   387 ERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFN 451
            |||||||.||||||||||||||||:||||||||..||||..|:|..|:|.||||||.|||||.||
Zfish   407 ERIGRDSGYEQEGKVQFVIDAVYAMAHALHSMHIDLCPGSMGVCDKMDPVDGRMLLTYIRAVNFN 471

Human   452 GSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSS 516
            |||||.|||||||||||||||||||.:|  .::.||:.:|||...|||..|.:||||....||.|
Zfish   472 GSAGTGVMFNENGDAPGRYDIFQYQLSN--TTNPGYKLIGQWTNHLRLSAEDMQWSGGEKLVPDS 534

Human   517 LCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSW 581
            :||.||..||||:||||||||||||.||||:|.:|||.|:.||.|||||||.|.|||||:::|.|
Zfish   535 VCSFPCESGERKRMVKGVPCCWHCELCDGYQFLLDEFNCDMCPFDMRPTPNRTACRPTPIIKLEW 599

Human   582 SSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPG 646
            |||||..|:.||||||:|||.|:|||:|:|:|||||||||||||||||||||||.|||||:||||
Zfish   600 SSPWAIIPVFLAVLGILATTGVIATFIRFNDTPIVRASGRELSYVLLTGIFLIYLITFLMIAEPG 664

Human   647 AAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVG 711
            ..|||.|||.||||..:||||:|||||||||||||||:|||||.||||||||:|||.|.|:|::|
Zfish   665 TVVCAFRRLLLGLGMCISYSAMLTKTNRIYRIFEQGKKSVTPPKFISPTSQLIITFILISVQLLG 729

Human   712 MIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVP 776
            :..|.|..|||:.:|::|.|..:||.|||:||||||||||||||.||:.|||||||||||:||||
Zfish   730 IFIWFGVVPPHTNVDFDELRPPNPEFARGILKCDMSDLSLIGCLSYSMGLMVTCTVYAIKSRGVP 794

Human   777 ETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTY 841
            ||||||||||||||||||||||||||||||:||.||::|||||||||:||||:|||||||:||.|
Zfish   795 ETFNEAKPIGFTMYTTCIIWLAFVPIFFGTSQSTEKMFIQTTTLTVSMSLSATVSLGMLYIPKVY 859

Human   842 VILFHPEQNVQKRKRSLKATSTVA 865
            ||:|||||||||||||.||.:..|
Zfish   860 VIIFHPEQNVQKRKRSFKAVAQAA 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM6	NP_000834.2	PBP1_mGluR_groupIII	45..506	CDD:380599	354/460 (77%)
		NCD3G	514..564	CDD:462210	35/49 (71%)
		7tmC_mGluR6	584..856	CDD:320569	213/271 (79%)
		TM helix 1	584..609	CDD:320569	17/24 (71%)
		TM helix 2	621..642	CDD:320569	19/20 (95%)
		TM helix 3	651..673	CDD:320569	15/21 (71%)
		TM helix 4	699..715	CDD:320569	7/15 (47%)
		TM helix 5	747..770	CDD:320569	19/22 (86%)
		TM helix 6	779..804	CDD:320569	24/24 (100%)
		TM helix 7	814..839	CDD:320569	20/24 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	856..877		5/10 (50%)
grm6b	NP_001073489.2	PBP1_mGluR_groupIII	58..524	CDD:380599	360/472 (76%)
		NCD3G	532..582	CDD:462210	35/49 (71%)
		7tmC_mGluR_group3	602..872	CDD:320413	211/269 (78%)
		TM helix 1	602..627	CDD:320413	17/24 (71%)
		TM helix 2	639..660	CDD:320413	19/20 (95%)
		TM helix 3	669..693	CDD:320413	17/23 (74%)
		TM helix 4	715..735	CDD:320413	10/19 (53%)
		TM helix 5	765..791	CDD:320413	22/25 (88%)
		TM helix 6	799..822	CDD:320413	22/22 (100%)
		TM helix 7	832..857	CDD:320413	20/24 (83%)