DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRM6 and mGluR

DIOPT Version :10

Sequence 1:NP_000834.2 Gene:GRM6 / 2916 HGNCID:4598 Length:877 Species:Homo sapiens
Sequence 2:NP_524639.2 Gene:mGluR / 43838 FlyBaseID:FBgn0019985 Length:976 Species:Drosophila melanogaster


Alignment Length:906 Identity:396/906 - (43%)
Similarity:540/906 - (59%) Gaps:76/906 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    11 LLVALLPLAWLAQAGLARAAG-------SVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHR 68
            :||.::.|:|.....|...:.       ||.|.|.:.||||||||.:| .|..||.....:||.|
  Fly    10 ILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQR 73

Human    69 LEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRC-PG 132
            |||||||:||||.||.:|||:.:|..:|||||||||||.|:|.||:|.:...   |..|..| .|
  Fly    74 LEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNL---DTSGYECADG 135

Human   133 GVPPLRP-APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPP 196
            ..|.||. |....|..|:|.|.||||:.|||:||||.|||:|.||||..|||.||:|.|:|.|||
  Fly   136 SSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPP 200

Human   197 DSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFS 261
            |::|:.|:|||::...|:||||:.|||:|||.|:||..:.:.|. .||||.:.|:|.......|.
  Fly   201 DTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDKVFD 264

Human   262 KVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGA 326
            .:|.:|.:.|||||:::|...:|.||:|:||::|||:..|.|:.||.||.:...:..|||:|.||
  Fly   265 SIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGA 329

Human   327 ITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDST----------- 380
            ||:..:...|..||:|.|..:.|.|:||.||||:||:.|||.|||...:.|.|.           
  Fly   330 ITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGV 394

Human   381 ---RKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTG-------------- 428
               .:|....|:.....||||.|.|||:|||||.|:|||::|...|...:.              
  Fly   395 KAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESV 459

Human   429 ------------LCPAMEPTDGRMLL-QYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG 480
                        .||.|...||:... .|:..|.|...||:.|.|:..||...||||..||.   
  Fly   460 WYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQR--- 521

Human   481 SASSGGYQ--AVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEAC 543
            ..:|.|||  .:|:|...|:|:.|.:.|:.:. |.|:|.|||||..|..||. :|..|||.|::|
  Fly   522 QENSSGYQYKVIGKWFNGLQLNSETVVWNKET-EQPTSACSLPCEVGMIKKQ-QGDTCCWICDSC 584

Human   544 DGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFV 608
            :.:.:..|||||:.|...:.|..:...|....:..:.|:|.:|..|:.:|:.||..|:.|:..|.
  Fly   585 ESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFA 649

Human   609 RYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTN 673
            :.::||:||||||||||.||.||.:.|..||.::|:|....|..:|..:|:|.::.|||||||||
  Fly   650 KNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTN 714

Human   674 RIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQA 738
            ||.|||....:|.....:|||.||:|||.||.::||:..:.|:...||.:...|.::|.|     
  Fly   715 RISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREV----- 774

Human   739 RGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIF 803
              :|||.:.|:|.:....|:::|:..||:||||.|.:||.|||:|.||||||||||||||||||:
  Fly   775 --ILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIY 837

Human   804 FGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTV 864
            |||..|.|   :|||||.:|:||||||:|..||.||.|:::|||::||:|    |...|||
  Fly   838 FGTGNSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRK----LTMNSTV 891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRM6NP_000834.2 PBP1_mGluR_groupIII 45..506 CDD:380599 218/505 (43%)
NCD3G 514..564 CDD:462210 22/49 (45%)
7tmC_mGluR6 584..856 CDD:320569 133/271 (49%)
TM helix 1 584..609 CDD:320569 8/24 (33%)
TM helix 2 621..642 CDD:320569 12/20 (60%)
TM helix 3 651..673 CDD:320569 10/21 (48%)
TM helix 4 699..715 CDD:320569 7/15 (47%)
TM helix 5 747..770 CDD:320569 7/22 (32%)
TM helix 6 779..804 CDD:320569 22/24 (92%)
TM helix 7 814..839 CDD:320569 15/24 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..877 4/9 (44%)
mGluRNP_524639.2 PBP1_mGluR_groupII 39..542 CDD:380598 223/510 (44%)
NCD3G 556..605 CDD:462210 22/49 (45%)
7tmC_mGluRs_group2_3 625..876 CDD:320600 127/260 (49%)
TM helix 1 625..650 CDD:320600 8/24 (33%)
TM helix 2 662..683 CDD:320600 12/20 (60%)
TM helix 3 692..716 CDD:320600 12/23 (52%)
TM helix 4 738..758 CDD:320600 9/19 (47%)
TM helix 5 781..807 CDD:320600 10/25 (40%)
TM helix 6 815..838 CDD:320600 20/22 (91%)
TM helix 7 845..870 CDD:320600 16/27 (59%)

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