DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRM6 and mtt

DIOPT Version :10

Sequence 1:NP_000834.2 Gene:GRM6 / 2916 HGNCID:4598 Length:877 Species:Homo sapiens
Sequence 2:NP_001260806.1 Gene:mtt / 35832 FlyBaseID:FBgn0050361 Length:1472 Species:Drosophila melanogaster


Alignment Length:870 Identity:358/870 - (41%)
Similarity:525/870 - (60%) Gaps:59/870 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    37 GGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSR 101
            |.:.||||..||:| .....||.:..:.|:..|||||:.:||:|.: :|||.:.|||.:||.|.:
  Fly   393 GDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDCDK 455

Human   102 DTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVA-VVGASASSVSIMVANVLR 165
            |:|.||.|:.|::..|   .:.|:....|       ......:|:: ||||::|..||.|||:||
  Fly   456 DSYGLEMAVDFIKGSI---SNIDDAEYHC-------NKTQVRKVISGVVGAASSVTSIQVANLLR 510

Human   166 LFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGV 230
            ||.|||:||.||:||||:..|:::|||.:|.|.||.:|||:||:.:||:|||.:..|.||   |:
  Fly   511 LFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GI 572

Human   231 EAFVQISR--EAGGVCIAQSIKIPREPKPGE---FSKVIRRLMETPNARGIIIFANEDDIRRVLE 290
            :||.::..  ....:|||...|:.::....|   :..::::|:..|.|||.|||.::.::|:|:.
  Fly   573 KAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMR 637

Human   291 AARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNI 355
            |.|:||.||.|.|:|||.|.|:.......|....|.:::.|:...:.||::||::.::|||:||.
  Fly   638 AVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702

Human   356 WFAEFWEENFNCKLT-SSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMH 419
            ||.||||::|.|:.. |:.|..::.|::||.:||:.|.:| :.|.::|||.|||.|.|:||..||
  Fly   703 WFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAVMAFAYALRDMH 766

Human   420 QALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASS 484
            :.||.|...||.||:||.|..||:|:|.|.|.|.:|....|:.|||.|.||:|..::    .:.:
  Fly   767 RDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFK----QSQA 827

Human   485 GGYQ--AVGQWAE-TLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGY 546
            |.|.  .||::.| .|||::..:::.....:.|.|:|||||..|:.||.|:|..|||||..|..|
  Fly   828 GQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTY 892

Human   547 --RFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVR 609
              |...||..|:.|.....|..:...|||.|.:.|...|.||...:..:..||:.|..|:..|||
  Fly   893 QIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVR 957

Human   610 YNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNR 674
            :|:|||||||||||||:||.|||:.|.:||.:|.:|...|||.:|..:|...|:.|:||||||||
  Fly   958 HNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNR 1022

Human   675 IYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQAR 739
            |.|||:.||:|...|.||||.|||||...|.|:|::....|:...|.|::..|       |.:..
  Fly  1023 IARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY-------PTRED 1080

Human   740 GVLKCD-MSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIF 803
            .:|.|| ..|.|.:....|.:.|:|.|||||:..|.:||.|||:|.|||||||||:|||||||::
  Fly  1081 NLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLY 1145

Human   804 FGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKR-------------- 854
            |||   |..:.::.|:::|::||||||::..|:.||.|:||..||:||::.              
  Fly  1146 FGT---ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAG 1207

Human   855 --KRSLKATSTVAAPPKGEDAEAHK 877
              ..|:.|.:.|.|....::.:..|
  Fly  1208 TGPSSMMAAAVVTAATCAQEEKIQK 1232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRM6NP_000834.2 PBP1_mGluR_groupIII 45..506 CDD:380599 186/470 (40%)
NCD3G 514..564 CDD:462210 24/51 (47%)
7tmC_mGluR6 584..856 CDD:320569 131/288 (45%)
TM helix 1 584..609 CDD:320569 7/24 (29%)
TM helix 2 621..642 CDD:320569 13/20 (65%)
TM helix 3 651..673 CDD:320569 10/21 (48%)
TM helix 4 699..715 CDD:320569 5/15 (33%)
TM helix 5 747..770 CDD:320569 9/22 (41%)
TM helix 6 779..804 CDD:320569 20/24 (83%)
TM helix 7 814..839 CDD:320569 9/24 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..877 4/20 (20%)
mttNP_001260806.1 Periplasmic_Binding_Protein_type1 73..>157 CDD:471960
PBP1_mGluR 393..848 CDD:380585 191/474 (40%)
NCD3G 860..912 CDD:462210 24/51 (47%)
7tmC_mGluRs 932..1184 CDD:320173 126/261 (48%)
TM helix 1 932..957 CDD:320173 7/24 (29%)
TM helix 2 969..990 CDD:320173 13/20 (65%)
TM helix 3 999..1023 CDD:320173 12/23 (52%)
TM helix 4 1045..1065 CDD:320173 8/19 (42%)
TM helix 5 1089..1115 CDD:320173 10/25 (40%)
TM helix 6 1123..1146 CDD:320173 18/22 (82%)
TM helix 7 1153..1178 CDD:320173 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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