Protein Alignment GRM6 and Grm6

DIOPT Version :10

• Sequence 1: NP_000834.2
• Gene: GRM6 / 2916
• HGNCID: 4598
• Length: 877
• Species: Homo sapiens
• Sequence 2: NP_075209.1
• Gene: Grm6 / 24419
• RGDID: 2747
• Length: 871
• Species: Rattus norvegicus
• Alignment Length: 868
• Identity: 817/868 - (94%)
• Similarity: 838/868 - (96%)
• Gaps: 1/868 - (0%)

Human    11 LLVALLPLA-WLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLY 74
            |.|.||.|| ||:|||:|..|||||||||||||||||||||||||||||.|||||||||||||||
  Rat     4 LPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLY 68

Human    75 ALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRP 139
            |||||||||||||||||||||||||||||||||||||||||||||||||||..|||||||||||.
  Rat    69 ALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRS 133

Human   140 APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAM 204
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   134 APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAM 198

Human   205 VDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
  Rat   199 VDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLME 263

Human   270 TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRA 334
            ||||||||||||||||||||||.||||||||||||||||||:|.||||:||:.||||||||||||
  Rat   264 TPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRA 328

Human   335 SIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEG 399
            |||||||||||||||||||||||||||||||||||||||.||||||||||||||||:||.|||||
  Rat   329 SIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEG 393

Human   400 KVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENG 464
            ||||||||||||||||||||||||||||||||||||||||.||.|||||||||||||||||||||
  Rat   394 KVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENG 458

Human   465 DAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKK 529
            |||||||||||||||||||||||||||||||.||||:|.|:|||||||||.|.||||||||||||
  Rat   459 DAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKK 523

Human   530 MVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAV 594
            ||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||.||||||
  Rat   524 MVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAV 588

Human   595 LGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGL 659
            |||:||||::|||:|:|:|||||||||||||||||||||||||||||||||.||:||||||.|||
  Rat   589 LGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGL 653

Human   660 GTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSV 724
            |||||||||||||||||||||||||||||||||||||||||||.||||||||:||||||:|||||
  Rat   654 GTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSV 718

Human   725 IDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTM 789
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   719 IDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTM 783

Human   790 YTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKR 854
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   784 YTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKR 848

Human   855 KRSLKATSTVAAPPKGEDAEAHK 877
            |||||.|||:||||:.|:||..|
  Rat   849 KRSLKKTSTMAAPPQNENAEDAK 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM6	NP_000834.2	PBP1_mGluR_groupIII	45..506	CDD:380599	441/460 (96%)
		NCD3G	514..564	CDD:462210	47/49 (96%)
		7tmC_mGluR6	584..856	CDD:320569	258/271 (95%)
		TM helix 1	584..609	CDD:320569	20/24 (83%)
		TM helix 2	621..642	CDD:320569	20/20 (100%)
		TM helix 3	651..673	CDD:320569	20/21 (95%)
		TM helix 4	699..715	CDD:320569	13/15 (87%)
		TM helix 5	747..770	CDD:320569	22/22 (100%)
		TM helix 6	779..804	CDD:320569	24/24 (100%)
		TM helix 7	814..839	CDD:320569	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	856..877		14/20 (70%)
Grm6	NP_075209.1	PBP1_mGluR_groupIII	39..500	CDD:380599	441/460 (96%)
		NCD3G	508..558	CDD:462210	47/49 (96%)
		7tm_GPCRs	578..850	CDD:475119	258/271 (95%)
		TM helix 1	579..603	CDD:320569	19/23 (83%)
		TM helix 2	615..636	CDD:320569	20/20 (100%)
		TM helix 3	645..667	CDD:320569	20/21 (95%)
		TM helix 4	693..709	CDD:320569	13/15 (87%)
		TM helix 5	741..764	CDD:320569	22/22 (100%)
		TM helix 6	776..798	CDD:320569	21/21 (100%)
		TM helix 7	808..833	CDD:320569	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	850..871		14/20 (70%)