DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRM6 and mgl-3

DIOPT Version :10

Sequence 1:NP_000834.2 Gene:GRM6 / 2916 HGNCID:4598 Length:877 Species:Homo sapiens
Sequence 2:NP_001076735.3 Gene:mgl-3 / 177327 WormBaseID:WBGene00021152 Length:1008 Species:Caenorhabditis elegans


Alignment Length:856 Identity:332/856 - (38%)
Similarity:480/856 - (56%) Gaps:60/856 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    20 WLAQAGLARAAGSVRLAGGLTLGGLFPVHARGA-AGRACGQLKKEQGVHRLEAMLYALDRVNADP 83
            :|....::.....:.:.|.:.||||||:|..|. |...||::|.:|||.|:.|||:||::||.|.
 Worm    26 FLLHIPISSTVKQLTVPGQIVLGGLFPIHEAGRNASHQCGKIKADQGVQRMVAMLFALEKVNRDR 90

Human    84 ELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAV 148
            :|||...|||::|||||.|:|||||.|.|:::::   .:||  ||.|..|........|  ||||
 Worm    91 QLLPQASLGAQILDTCSVDSYALEQTLEFIKSVM---SNGD--GVTCADGSTGSYTRQP--VVAV 148

Human   149 VGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGW 213
            |||:.|.||:|||::|:||.|||:||:||..|||:..|:.|||||||||:.|||.|..::.||.|
 Worm   149 VGAAGSQVSVMVASMLQLFKIPQVSYSSTGAELSEKPRFAFFSRVVPPDNLQAQVMARVIGALEW 213

Human   214 NYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSI-KIPREPKPGEFSKVIRRLMETPNARGII 277
            .||..:|..|:|||.|:::|...:.| .|:||...: ||.|......|..::.|:..|..|||::
 Worm   214 TYVHAIADTGSYGERGMDSFRAAAAE-NGICIDGDVQKISRRWTEKNFRDLLIRMHRTRKARGVV 277

Human   278 IFANEDDIRRVLE------AARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASI 336
            :|.:||:::|:|:      |.....|..||.:|.|||||.|.|.:..||....|||||.|.....
 Worm   278 MFVDEDNLKRLLKTLDLLVAEGHTELDRHFWFVASDSWGIKQSVVRGLEHRTYGAITIAPMVREE 342

Human   337 DGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKV 401
            .|:.:||  |||  :.:...|.|.:.|...|..|.......|    |.....|    |.:||..|
 Worm   343 TGYLEYF--RSL--SPKGFVFLEEFFEYLGCSATVDVKTFGD----CFDMVNI----TLKQESYV 395

Human   402 QFVIDAVYAIAHALHSMHQALC---PGHTGLCP-AMEPTDGRMLLQYIRAVRFNGSAGTPVMFNE 462
            .||:|.|..||.|:....:..|   |.|.  |. |.....|..|.:|.|.:..  ....|.:.:.
 Worm   396 PFVVDTVKIIAKAISMYIEDDCGKIPFHK--CTLAQSGFRGERLQRYYRNMSL--IKNEPALIDA 456

Human   463 NGDAPGRYDIFQYQATNGSASSGGYQAVGQWAET---LRLDVEALQWS-GDPH-EVPSSLCSLPC 522
            |||..||||:||...      :|.||.||:|..|   |.::||.::.: ...| |.|.|:||..|
 Worm   457 NGDGIGRYDVFQLDI------NGVYQKVGKWRSTDDFLSVEVEKIRHAFKTAHGERPMSVCSTDC 515

Human   523 GPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAA 587
             |....:..:...|||.|..||......:|.:||.|...|.|......|.|.|.|.:.|.:.|:.
 Worm   516 -PRGHYRAYQDQTCCWACIPCDTSTSIHNETSCEECAVGMVPDRTLHFCVPIPPVSMQWDTTWSL 579

Human   588 PPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAA 652
            .|...:.|||.:|..||:.|::::|||::.||||||.|.:::||.:.|.:||.:|::|....|:.
 Worm   580 IPAAFSTLGIASTIFVVSVFLKFSNTPVIMASGRELCYCMMSGIGMCYTLTFFLVSQPTVITCSM 644

Human   653 RRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLG 717
            .|:.:||..:..|:|::|||||:.|:|:..  |...|.||:|.:|:.|...:.|:|::|...|:.
 Worm   645 TRILMGLSMSAIYAAIITKTNRLARVFKPD--SAQRPRFITPKAQVGICMGIVSVQLIGTFVWIL 707

Human   718 ARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEA 782
            ..||.::|       |.|.:...||.|..:...|:..|.|::||:|.|||||.|.|.:||.|||.
 Worm   708 FDPPGTMI-------VFPTRTEAVLTCKATTSHLLISLLYNILLIVACTVYAFKTRKIPENFNET 765

Human   783 KPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHP 847
            :.||||||:|||:||||.||:|.|...   ..||.|:|.:.:|||.:|:|...:.||.|::||.|
 Worm   766 RHIGFTMYSTCILWLAFGPIYFATQSD---FRIQITSLCMCISLSGTVALICFFAPKVYIVLFQP 827

Human   848 EQNVQKRKRSL 858
            .:||:.|:.::
 Worm   828 YKNVRTRQSAV 838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRM6NP_000834.2 PBP1_mGluR_groupIII 45..506 CDD:380599 190/475 (40%)
NCD3G 514..564 CDD:462210 17/49 (35%)
7tmC_mGluR6 584..856 CDD:320569 111/271 (41%)
TM helix 1 584..609 CDD:320569 9/24 (38%)
TM helix 2 621..642 CDD:320569 9/20 (45%)
TM helix 3 651..673 CDD:320569 7/21 (33%)
TM helix 4 699..715 CDD:320569 4/15 (27%)
TM helix 5 747..770 CDD:320569 10/22 (45%)
TM helix 6 779..804 CDD:320569 18/24 (75%)
TM helix 7 814..839 CDD:320569 9/24 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..877 0/3 (0%)
mgl-3NP_001076735.3 Periplasmic_Binding_Protein_type1 41..493 CDD:471960 193/481 (40%)
NCD3G 507..556 CDD:462210 17/49 (35%)
7tmC_mGluRs_group2_3 577..825 CDD:320600 105/259 (41%)
TM helix 1 577..601 CDD:320600 9/23 (39%)
TM helix 2 613..634 CDD:320600 9/20 (45%)
TM helix 3 643..667 CDD:320600 9/23 (39%)
TM helix 4 687..707 CDD:320600 6/19 (32%)
TM helix 5 730..756 CDD:320600 12/25 (48%)
TM helix 6 764..787 CDD:320600 16/22 (73%)
TM helix 7 794..819 CDD:320600 9/24 (38%)

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