Protein Alignment GRM6 and Grm6

DIOPT Version :10

• Sequence 1: NP_000834.2
• Gene: GRM6 / 2916
• HGNCID: 4598
• Length: 877
• Species: Homo sapiens
• Sequence 2: NP_775548.2
• Gene: Grm6 / 108072
• MGIID: 1351343
• Length: 871
• Species: Mus musculus
• Alignment Length: 868
• Identity: 817/868 - (94%)
• Similarity: 839/868 - (96%)
• Gaps: 1/868 - (0%)

Human    11 LLVALLPLA-WLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLY 74
            |.|.||.|| ||:|||:|..|||||||||||||||||||||||||||||.|||||||||||||||
Mouse     4 LRVLLLWLAWWLSQAGIAHGAGSVRLAGGLTLGGLFPVHARGAAGRACGTLKKEQGVHRLEAMLY 68

Human    75 ALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRP 139
            ||||:||||||||||||||||||||||||||||||||||||||||||||:|..|||||||||||.
Mouse    69 ALDRINADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGEEASVRCPGGVPPLRA 133

Human   140 APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAM 204
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   134 APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAM 198

Human   205 VDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
Mouse   199 VDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLME 263

Human   270 TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRA 334
            ||||||||||||||||||||||.||||||||||||||||||:|.||||:||:.||||||||||||
Mouse   264 TPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRA 328

Human   335 SIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEG 399
            |||||||||||||||||||||||||||||||||||||||.||||||||||||||||:||||||||
Mouse   329 SIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSTYEQEG 393

Human   400 KVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENG 464
            ||||||||||||||||||||||||||||||||||||||||.||.|||||||||||||||||||||
Mouse   394 KVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENG 458

Human   465 DAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKK 529
            |||||||||||||||||||||||||||||||.||||:|||||||||||||.|.||||||||||||
Mouse   459 DAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEALQWSGDPHEVPPSQCSLPCGPGERKK 523

Human   530 MVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAV 594
            |||||||||||||||||||||||||||||||.||||||||||||||||||:|||||||.||||||
Mouse   524 MVKGVPCCWHCEACDGYRFQVDEFTCEACPGHMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAV 588

Human   595 LGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGL 659
            |||:||||::|||:|:|:|||||||||||||||||||||||||||||||||.|||||:|||.|||
Mouse   589 LGIMATTTIIATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAVCASRRLLLGL 653

Human   660 GTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSV 724
            |||||||||||||||||||||||||||||||||||||||||||.||||||||:||||||:|||||
Mouse   654 GTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSV 718

Human   725 IDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTM 789
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   719 IDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTM 783

Human   790 YTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKR 854
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   784 YTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKR 848

Human   855 KRSLKATSTVAAPPKGEDAEAHK 877
            |||||.|||:|||||.|::|..|
Mouse   849 KRSLKKTSTMAAPPKSENSEDAK 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM6	NP_000834.2	PBP1_mGluR_groupIII	45..506	CDD:380599	441/460 (96%)
		NCD3G	514..564	CDD:462210	46/49 (94%)
		7tmC_mGluR6	584..856	CDD:320569	258/271 (95%)
		TM helix 1	584..609	CDD:320569	20/24 (83%)
		TM helix 2	621..642	CDD:320569	20/20 (100%)
		TM helix 3	651..673	CDD:320569	19/21 (90%)
		TM helix 4	699..715	CDD:320569	13/15 (87%)
		TM helix 5	747..770	CDD:320569	22/22 (100%)
		TM helix 6	779..804	CDD:320569	24/24 (100%)
		TM helix 7	814..839	CDD:320569	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	856..877		14/20 (70%)
Grm6	NP_775548.2	PBP1_mGluR_groupIII	39..500	CDD:380599	441/460 (96%)
		NCD3G	508..558	CDD:462210	46/49 (94%)
		7tm_GPCRs	578..850	CDD:475119	258/271 (95%)
		TM helix 1	579..603	CDD:410628	19/23 (83%)
		TM helix 2	615..636	CDD:410628	20/20 (100%)
		TM helix 3	645..667	CDD:410628	19/21 (90%)
		TM helix 4	693..709	CDD:410628	13/15 (87%)
		TM helix 5	741..764	CDD:410628	22/22 (100%)
		TM helix 6	776..798	CDD:410628	21/21 (100%)
		TM helix 7	808..833	CDD:410628	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	848..871		16/22 (73%)