Protein Alignment GRM6 and grm8l

DIOPT Version :10

• Sequence 1: NP_000834.2
• Gene: GRM6 / 2916
• HGNCID: 4598
• Length: 877
• Species: Homo sapiens
• Sequence 2: XP_017946013.2
• Gene: grm8l / 100489237
• XenbaseID: XB-GENE-953825
• Length: 886
• Species: Xenopus tropicalis
• Alignment Length: 837
• Identity: 646/837 - (77%)
• Similarity: 730/837 - (87%)
• Gaps: 7/837 - (0%)

Human    29 AAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGA 93
            |..|:::.|.:||||||||||:|.||..||::|||.|||||||||||||::|.||||||.:.|||
 Frog    26 AQHSIKIDGDITLGGLFPVHAKGPAGTPCGEVKKEAGVHRLEAMLYALDQINGDPELLPNLTLGA 90

Human    94 RLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSI 158
            |:|||||||||||||:|:||||||:    .|...:||..|.||:. :.|||||.|:|||||||||
 Frog    91 RILDTCSRDTYALEQSLTFVQALIQ----KDTSDIRCSNGDPPIL-SRPERVVGVIGASASSVSI 150

Human   159 MVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEG 223
            |||||||||:|||||||||||||||:.|||||||||||||||||||||||:||||||||||||||
 Frog   151 MVANVLRLFSIPQISYASTAPELSDNNRYDFFSRVVPPDSYQAQAMVDIVKALGWNYVSTLASEG 215

Human   224 NYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRV 288
            ||||||||||:|||||||||||||||||||||:||||.||||||:|||||||||||||||||:||
 Frog   216 NYGESGVEAFMQISREAGGVCIAQSIKIPREPRPGEFDKVIRRLLETPNARGIIIFANEDDIKRV 280

Human   289 LEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRR 353
            |||:::||.|||||||||||||:||||:|.||:||.||:|||||||||:||||||.:|:||||||
 Frog   281 LEASQRANQTGHFLWVGSDSWGSKTSPVLGLEEVAEGAVTILPKRASIEGFDQYFTSRTLENNRR 345

Human   354 NIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSM 418
            |||||||||::|.|:||.|..:.:|..|||||.|||.:||.||||||||||||||||:|||||:|
 Frog   346 NIWFAEFWEDDFKCRLTRSAARPEDPRRKCTGGERIAKDSAYEQEGKVQFVIDAVYAMAHALHNM 410

Human   419 HQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSAS 483
            |..|||||:|:|..|:|.:||:||:||..|.|||||||||||||||||||||||||||..|.||.
 Frog   411 HVDLCPGHSGVCDKMDPIEGRLLLRYIHRVNFNGSAGTPVMFNENGDAPGRYDIFQYQMANDSAP 475

Human   484 SGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF 548
            |  |:.:|||.|.|||.:|.:||||...::|||:|||||.||||||||||||||||||.||||:|
 Frog   476 S--YRVIGQWTEYLRLSIEEMQWSGGQSDIPSSVCSLPCQPGERKKMVKGVPCCWHCELCDGYQF 538

Human   549 QVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNT 613
            |:|:|||:.||.||||..|.|.||.||:::|.|:|.||..||.||::||::|..||.|.||:|:|
 Frog   539 QLDDFTCQLCPFDMRPNENRTACRATPIIKLEWTSAWAVLPLFLAIVGILSTLFVVGTLVRFNDT 603

Human   614 PIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRI 678
            ||||||||||||||||||||:|||||||:.|||.||||.||||||||..:||:||||||||||||
 Frog   604 PIVRASGRELSYVLLTGIFLMYAITFLMMGEPGVAVCALRRLFLGLGMCISYAALLTKTNRIYRI 668

Human   679 FEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLK 743
            |||||||||||.||||.|||||||||..:|:||...||...||||.||||||||.:||.||||||
 Frog   669 FEQGKRSVTPPRFISPASQLVITFSLIGVQLVGTSVWLAVLPPHSFIDYEEQRTPNPENARGVLK 733

Human   744 CDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQ 808
            ||||||||:.||.||:||||||||||:|||||||.||||||||||||||||:|||||||||||||
 Frog   734 CDMSDLSLVSCLMYSILLMVTCTVYAVKARGVPENFNEAKPIGFTMYTTCIVWLAFVPIFFGTAQ 798

Human   809 SAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVA 865
            |||||||||||||||:|||||||||||||||.|||:|||||||||||||.||.:|.|
 Frog   799 SAEKIYIQTTTLTVSMSLSASVSLGMLYVPKVYVIIFHPEQNVQKRKRSFKAVATAA 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM6	NP_000834.2	PBP1_mGluR_groupIII	45..506	CDD:380599	354/460 (77%)
		NCD3G	514..564	CDD:462210	40/49 (82%)
		7tmC_mGluR6	584..856	CDD:320569	222/271 (82%)
		TM helix 1	584..609	CDD:320569	12/24 (50%)
		TM helix 2	621..642	CDD:320569	19/20 (95%)
		TM helix 3	651..673	CDD:320569	16/21 (76%)
		TM helix 4	699..715	CDD:320569	9/15 (60%)
		TM helix 5	747..770	CDD:320569	18/22 (82%)
		TM helix 6	779..804	CDD:320569	23/24 (96%)
		TM helix 7	814..839	CDD:320569	23/24 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	856..877		6/10 (60%)
grm8l	XP_017946013.2	PBP1_mGluR_groupIII	30..496	CDD:380599	360/472 (76%)
		NCD3G	504..554	CDD:462210	40/49 (82%)
		7tmC_mGluR_group3	574..844	CDD:320413	220/269 (82%)
		TM helix 1	574..599	CDD:320413	12/24 (50%)
		TM helix 2	611..632	CDD:320413	19/20 (95%)
		TM helix 3	641..665	CDD:320413	18/23 (78%)
		TM helix 4	687..707	CDD:320413	12/19 (63%)
		TM helix 5	737..763	CDD:320413	20/25 (80%)
		TM helix 6	771..794	CDD:320413	21/22 (95%)
		TM helix 7	804..829	CDD:320413	23/24 (96%)