DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vnn1 and CG32751

DIOPT Version :9

Sequence 1:	NP_001020794.1	Gene:	Vnn1 / 29142	RGDID:	1310075	Length:	512	Species:	Rattus norvegicus
Sequence 2:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	148/558 - (26%)
Similarity:	230/558 - (41%)	Gaps:	128/558 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MSLSRWLAWAAAFSVFC-----VLKVS---SL---DTFLAAVYEHAVILPKVTLLPVSHSEALAL 54
            |:.:.|     .|.:||     :|.:|   ||   |.:.|.|.|..   |.
  Fly     1 MAKNYW-----GFFLFCLALGLMLNLSQQASLFKRDFYTAGVVEFE---PS-------------- 43

  Rat    55 MNQNLDLLEGAILSAAKQGA---HIIVTPEDGIYGVQFTRDTIYPYLEDIPDPQVNWIPC-DNPE 115
             |:..|.|.|.:.....|.|   .|||.||..:.....|  |..|.    |:.|:|  || .:|
  Fly    44 -NELSDNLAGYLEIIQSQNATSTDIIVFPESTLNSAGST--TFVPN----PEDQIN--PCLSDP- 98

  Rat   116 RFGSTPVQE---RLSCLAKNNSIYVVANMGDKKPCN--TSDSH-CPPDGRFQYNTDVVFDSRGKL 174
              .:|..:|   .|||.|:|.|.|:|.|:.:|:.|.  ..|:. |..:|...:||:||||.:|.:
  Fly    99 --NATYYEEFLVTLSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVV 161

  Rat   175 VARYHKQNLFMGEEQFNAPPEPEVVTFDTPFG-KFGIFTCFDILFHDPAVTLVTEFQVDTILFPT 238
            |:||.|.:|: ||.: |:...||:.||:|.|| .||.|.||||||:.||..|:.|..:...::|.
  Fly   162 VSRYRKVHLY-GEPK-NSTFLPELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPA 224

  Rat   239 AWMDVLPHLA--------AIEFHSAWAIGMGVNFLAANLHIPLRRMTGSGIYAPDSPRAFHYDR- 294
            .|...||.|.        |::....|:....||.|||....|:...:|||||...|.......|
  Fly   225 MWFSQLPFLTVNGIFSSKAVQIQLGWSYANNVNLLAAGASDPIVGNSGSGIYHGRSGSLRSVMRQ 289

  Rat   295 KTQEGKLLLAQLDSHPSHSPVNWTSYASSVEAPPTEKEEFRSFV-----------FFDEFTFVEL 348
            ::.|..:.:|::..:               .|....|.:.:..|           :.:.||..||
  Fly   290 ESGERSIYVARVPKY---------------RAKRRMKRDLKRQVATSSSFNIKRDYLENFTSEEL 339

  Rat   349 K---GITGNYT--VCQNDLCCHLSY------QMSEKRADEVYALGAFDGLHT---VEGQYHLQIC 399
            |   |..||.:  :|....|||...      :.|...:...|.:|.::|...   ::..| ::.|
  Fly   340 KIDAGKIGNLSQNLCHGGFCCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRNEKRLDVNY-IRNC 403

  Rat   400 ILLKCKTTNLRTCGS---SVDTASTRFEMFSLSGTFGTR---YVFPEVLLSE-VKLAPGEFQ--- 454
            .:..|...::..||.   .:......|....:..|:...   .:||:.||.. :.|.|.:|:
  Fly   404 GVFTCSGNSIDDCGQLLPDIQRPLVTFTHVEIRVTYPQSREFLLFPDTLLDNLLPLEPKQFEWSQ 468

  Rat   455 --VLSDGRLV------SLKPTSGPVLTVGLFGRLYEKD 484
              :..:...|      ||:...  :||.|::|..|..:
  Fly   469 KRISEESHQVRFALRKSLEVKH--LLTFGIYGNYYNNE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vnn1	NP_001020794.1	biotinidase_like	27..324	CDD:143591	97/316 (31%)
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	100/341 (29%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	38/181 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351401
Domainoid	1	1.000	87	1.000	Domainoid score	I7801
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9093
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.660