DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD274 and dpr6

DIOPT Version :9

Sequence 1:	NP_054862.1	Gene:	CD274 / 29126	HGNCID:	17635	Length:	290	Species:	Homo sapiens
Sequence 2:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	150	Identity:	37/150 - (24%)
Similarity:	60/150 - (40%)	Gaps:	42/150 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    11 TYWHLLNAFTVTVP-------KDLYVVEYGSNMTIEC--KFPVEKQLDLAALIVYWEMEDKNIIQ 66
            :|:..||   |.||       .||: |:.||.:.:.|  ||..|     ....::|
  Fly   166 SYFVRLN---VVVPTATILGGPDLH-VDKGSTINLTCTVKFSPE-----PPAYIFW--------- 212

Human    67 FVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVN 131
             .|.||  .:.:.|.|....::.::..:..:.|.|.:..|.|:|.|.|..|  .||...:.|.|
  Fly   213 -YHHEE--VINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGKYSCAPS--NADVASVRVHV- 271

Human   132 APYNKINQRILVVDPVTSEH 151
                 :|.|.:    ::.||
  Fly   272 -----LNVRAI----ISGEH 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD274	NP_054862.1	Ig	54..117	CDD:325142	13/62 (21%)
CD274	NP_054862.1	Ig	135..220	CDD:325142	3/16 (19%)
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	3/10 (30%)
		IG_like	80..175	CDD:214653	4/11 (36%)
		IG_like	184..271	CDD:214653	26/106 (25%)
		IGc2	191..262	CDD:197706	20/89 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910