DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD274 and side-III

DIOPT Version :9

Sequence 1:	NP_054862.1	Gene:	CD274 / 29126	HGNCID:	17635	Length:	290	Species:	Homo sapiens
Sequence 2:	NP_001036681.1	Gene:	side-III / 4379844	FlyBaseID:	FBgn0083949	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	222	Identity:	52/222 - (23%)
Similarity:	86/222 - (38%)	Gaps:	51/222 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRIFAVFIFMTYWHLLN-----------AFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALI 54
            :.:||:|:|..:..|.:           ..||.|...|     |...::.|....|.:.|...::
  Fly    26 LALFALFLFAAHISLTSGQIDWDDDDDPVSTVAVEAVL-----GRTASLPCDIEPEAKDDRVYMV 85

Human    55 VYW-EMEDKNIIQF-VHGEEDLKVQH----SSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYR 113
            ::: |...|.:..| |.|....|..:    :|:..||..:..|..   |.|.:.:::|.|.||||
  Fly    86 LWFRESAGKPLYSFDVRGRPFEKALYWSDTNSFGPRAYFVTGQQP---AKLSVDNIQLDDEGVYR 147

Human   114 CMISYGGADYK--RITVKVNAPYNKINQRILVVD-----------PVTSEHE--LTCQAE-GYPK 162
            |.:.:..:..:  ||.:.|..|    ..:|||.|           |:.....  |||:.. |.|:
  Fly   148 CRVDFQNSPTRNHRINLTVIVP----PHQILVYDASGRDVAGAVGPLLEGDNIVLTCEVRGGRPE 208

Human   163 AEVIWTSSDHQ------VLSGKTTTTN 183
            ..|.|.:....      |..|:..|.|
  Fly   209 PTVTWMNGTRTLEAGSGVSMGRHVTVN 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD274	NP_054862.1	Ig	54..117	CDD:325142	19/68 (28%)
CD274	NP_054862.1	Ig	135..220	CDD:325142	16/69 (23%)
side-III	NP_001036681.1	IG_like	59..166	CDD:214653	27/114 (24%)
		V-set	59..166	CDD:284989	27/114 (24%)
		ig	190..268	CDD:278476	11/46 (24%)
		IG_like	192..259	CDD:214653	11/44 (25%)
		Ig	296..361	CDD:299845
		IG_like	391..468	CDD:214653
		IGc2	392..454	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910