DRSC/TRiP Functional Genomics Resources

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Protein Alignment CD274 and Dscam1

DIOPT Version :9

Sequence 1:NP_054862.1 Gene:CD274 / 29126 HGNCID:17635 Length:290 Species:Homo sapiens
Sequence 2:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster


Alignment Length:237 Identity:57/237 - (24%)
Similarity:94/237 - (39%) Gaps:54/237 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    20 TVTVPKDLYVVE-------YGSNMTIECK---FPVEKQLDLAALIVYWEMEDKNIIQFVHGE-ED 73
            ||.|| ..:::|       .||:..:|||   ||..:        |.|    |..:....|| :|
  Fly   717 TVNVP-PRWILEPTDKAFAQGSDAKVECKADGFPKPQ--------VTW----KKAVGDTPGEYKD 768

Human    74 LKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYG-GADYKR-ITVKVNAP--- 133
            ||            ..|.:.:....|.:.:::..:.|.|.|....| |:.... |.:.|.||   
  Fly   769 LK------------KSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEF 821

Human   134 YNKI-NQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKL-FNVTST 196
            ..|: ||.....:|..    |.|:|:|.....::|..::.: |..|.....:.|||.| ..|.|:
  Fly   822 TEKLRNQTARRGEPAV----LQCEAKGEKPIGILWNMNNMR-LDPKNDNRYTIREEILSTGVMSS 881

Human   197 LRINTT---TNEIFYCTFRRLDPEENHTAELV---IPELPLA 232
            |.|..|   .:.:|.|........::.:..::   :||:|.|
  Fly   882 LSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYA 923

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CD274NP_054862.1 Ig 54..117 CDD:325142 13/63 (21%)
Ig 135..220 CDD:325142 22/89 (25%)
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352
IGc2 544..607 CDD:197706
Ig 641..714 CDD:143165
IGc2 735..804 CDD:197706 21/92 (23%)
I-set 819..914 CDD:254352 22/99 (22%)
Ig 833..921 CDD:299845 21/92 (23%)
FN3 918..1011 CDD:238020 4/6 (67%)
FN3 1018..1116 CDD:238020
FN3 1124..1217 CDD:238020
FN3 1222..1312 CDD:238020
Ig 1339..1406 CDD:299845
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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