Protein Alignment CTNNA3 and alpha-Cat

DIOPT Version :9

• Sequence 1: XP_016871641.1
• Gene: CTNNA3 / 29119
• HGNCID: 2511
• Length: 970
• Species: Homo sapiens
• Sequence 2: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Alignment Length: 974
• Identity: 470/974 - (48%)
• Similarity: 650/974 - (66%)
• Gaps: 83/974 - (8%)

Human     8 EKQGSMSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLA 72
            :|.|:::....|.|..||::|:::|.:|||.||||::||||||| .:.||.:|||:|||||.|:|
  Fly     5 DKMGTLTDFGQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVN-TKGPSKKKKGKSKRASALVA 68

Human    73 SVEEATWNLLDKGEKIAQEATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAA 137
            :||:||.|.:.|||:||.|...:..|:..:::||:|..:|:.::|..|::|||...||..:|:||
  Fly    69 AVEKATENFIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAA 133

Human   138 RALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFK 202
            |.||:|||||||||||:||..||:.:...:.....|||.:::.:|....::.|:....|...|.|
  Fly   134 RNLLSAVTRLLILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAK 198

Human   203 RQQVNNSGLNTTFAFSRKNLPTPKASDLKSPNQRDEIAGARASLKENSPLLHSICSACLEHSDVA 267
            |||                       :||.|..||::|.|||.||::|.:|.:.....:.|.::.
  Fly   199 RQQ-----------------------ELKDPQLRDDLAAARAMLKKHSTMLLTASKVYVRHPELD 240

Human   268 SLKASKDTVCEEIQNALNVISNASQGIQNMTTPPEPQAATLGSALDELENLIVLNPLTVTEEEIR 332
            ..|.::|.:.:::.:|:|.||:.:||..:..|.....|..|.:|||:.:..||::|:|.:|:..|
  Fly   241 LAKVNRDFILKQVCDAVNTISDVAQGKSSQPTDIYSGAGELAAALDDFDEGIVMDPMTYSEKRSR 305

Human   333 PSLEKRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNMRKLIPCRATRLT 397
            ..||:|||:|||.|||:||:.||||..||||:|||||:||||||||||||:||
  Fly   306 QLLEERLESIISAAALMADADCTRDERRERIVAECNAVRQALQDLLSEYMSNM------------ 358

Human   398 KTAPQVYLTSGLVDSKSTISLLHHEIKAGKKERSNTLNIALDNMCKKTRDLRRQLRKAIIDHVSD 462
                                        .:|:.|..|:.|:|.||:||||||||||||::|||||
  Fly   359 ----------------------------SQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSD 395

Human   463 SFLDTTVPLLVLIEAAKNGREKEIKEYAAIFHEHTSRLVEVANLACSMSTNEDGIKIVKIAANHL 527
            |||:||.|||.||||||:|.||:::|.:.||.:|..:|||||||.||||.||||:|:|:.||..:
  Fly   396 SFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQI 460

Human   528 ETLCPQIINAALALAARPKSQAVKNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILED 592
            |:||||:||||..|..||.|:..:..|..|::.||..:.:|||||||||:|||||||||:|||||
  Fly   461 ESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILED 525

Human   593 VNKCIIALRDQDADNLDRAAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIPEF 657
            ||||::||:..||.:|...||||:||::||.::|..|||:|||..||:.|:..|..|...|:.:|
  Fly   526 VNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKF 590

Human   658 VTQVNVALEALSKSSLNVLDDNQFVDISKKIYDTIHDIRCSVMMIRTPEEL------EDVSDLEE 716
            ..:|..|:.|||.:|...:|:|.|:|.|:.:||.:.:||.:|:|.|:.|:|      |.|.||..
  Fly   591 DQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLTL 655

Human   717 EHEVRS--HTSIQTEGK--------TDRAKMTQLPEAEKEKIAEQVADFKKVKSKLDAEIEIWDD 771
            |...||  ||..||..:        |.|..|.::.|.:|:|||:||..|::.|...|:|:..|||
  Fly   656 ETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWDD 720

Human   772 TSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPSC 836
            |.||||.|||:||||||||||||||:||||.|.|||.|||.|||:|:::|.|.|:||.|||:.|.
  Fly   721 TGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESST 785

Human   837 KQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTSLIQAAKNLMNAVVQTVKMSY 901
            |:||||||::|..|.||::|.|:|||::||:.||||:|.|||.|||||||||||||||.|||.||
  Fly   786 KKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYSY 850

Human   902 IASTKIIRIQSPAGPRHPVVMWRMKAPAKKPLIKREKPEETCAAVRRGSAKKKIHPLQVMSEFR 965
            :||||..|..:.:.   |:|:|:||||.||||::.|||||..|.||:||.||..:|:..:|||:
  Fly   851 VASTKYTRQGTVSS---PIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQ 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTNNA3	XP_016871641.1	None
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	406/855 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157783
Domainoid	1	1.000	672	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56187
OrthoDB	1	1.010	-	-		D405587at33208
OrthoFinder	1	1.000	-	-		FOG0002407
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103558
Panther	1	1.100	-	-	O	PTHR18914
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720