Protein Alignment TBK1 and KIC1

DIOPT Version :9

• Sequence 1: NP_037386.1
• Gene: TBK1 / 29110
• HGNCID: 11584
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_011970.1
• Gene: KIC1 / 856502
• SGDID: S000001144
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 546
• Identity: 115/546 - (21%)
• Similarity: 207/546 - (37%)
• Gaps: 157/546 - (28%)

Human     8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKLF 71
            |:..::::|:|....|::|.:.|||.::||||.|..|....|:...||.:.|..|.. .||.:.:
Yeast    22 LFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYY 86

Human    72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDI 136
            ....:.|:..  :|||.|..|||.::| .|..   :.|....:::|:::..:..:.::.::||||
Yeast    87 GSYLKDTSLW--IIMEHCAGGSLRSLL-RPGK---IDEKYIGVIMRELLVALKCIHKDNVIHRDI 145

Human   137 KPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLHPDMYERAVLRKDHQKKYGA 200
            |..|::  |..:|.  .||.|||.|.::.... :..::.||..::.|::....|.       |..
Yeast   146 KAANVL--ITNEGN--VKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVY-------YDT 199

Human   201 TVDLWSIGVTFYHAATGSLPFRPFEG------------PR------------------------- 228
            .||:||:|:|.|..|||:.|:...|.            ||
Yeast   200 KVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKER 264

Human   229 -----------------------------------RNKEVMYK----IITGKPSGAISGVQKAEN 254
                                               :||. .||    |...:||......:.::|
Yeast   265 LSADDLLKSKFIRAHKATPTSILKELISRYLLFRDKNKN-KYKIEGSIPENEPSKPSEAPKPSQN 328

Human   255 GPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQ- 318
            |    .||.......|...::      ..:.|.|.|..|.||..  .:||.:....|::.:|.:
Yeast   329 G----GGDEAQKSIASNDNEI------KRVNEGDVEMKWDFDSL--SSSDYIIENNINLDALAED 381

Human   319 ----MTA-HKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL-EPGRLAQHFPKTTEEN 377
                .|| |.::.::|.....::   :..|.  .:.:..:|:|..:.. .||.:||:   :|...
Yeast   382 NNEWATAQHDLFNYAYPDEDSYY---FDPTS--HNTRPFVYQGTTIGKGYPGTIAQN---STLNA 438

Human   378 PI---FVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVV-CYACRIASTLLLYQEL 438
            |:   :..|:.|                            :|.:.|.. ......|..:...:.|
Yeast   439 PVTNNYTNSKYP----------------------------SKMVAGTTNTSGTHTAGPMTSSKRL 475

Human   439 MRKGIRWLIELIKDDYNETVHKKTEV 464
            ..|..:.|:||.:|  ||.:..:.:|
Yeast   476 ESKAPKQLLELFED--NEIITAENDV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	S_TKc	9..242	CDD:214567	70/310 (23%)
		STKc_TBK1	15..330	CDD:270890	90/398 (23%)
		UBL_TBK1_like	297..385	CDD:240618	18/97 (19%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269|PubMed:21931631	621..729
KIC1	NP_011970.1	STKc_NAK1_like	21..295	CDD:270822	66/289 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910