DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBK1 and SSK22

DIOPT Version :9

Sequence 1:	NP_037386.1	Gene:	TBK1 / 29110	HGNCID:	11584	Length:	729	Species:	Homo sapiens
Sequence 2:	NP_009998.2	Gene:	SSK22 / 850436	SGDID:	S000000669	Length:	1331	Species:	Saccharomyces cerevisiae

Alignment Length:	256	Identity:	68/256 - (26%)
Similarity:	117/256 - (45%)	Gaps:	43/256 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     9 WLLSDILGQGATANVFRGRHKKTGDLFA---IKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70
            |.....:|.|....|:...:.:.|::.|   ||:.:..:..:...:...|..||:.|||.|||:.
Yeast  1034 WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQY 1098

Human    71 FAIEEETTTRHKV-LIMEFCPCGSLYTVLEEPSNAYGLPESEFL--IVLRDVVGGMNHLRENGIV 132
            :.:|   ..|.|| :.||:|..|||.::|:     :|..|.|.:  :...:::.|:.:|.::|:|
Yeast  1099 YGVE---VHRDKVNIFMEYCEGGSLASLLD-----HGRIEDEMVTQVYTFELLEGLAYLHQSGVV 1155

Human   133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----------------EDDEQFVSLYGTEEYL 180
            ||||||.||:.    |...:.|..|||.||.:                 .:.:....:.||..|:
Yeast  1156 HRDIKPENILL----DFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYM 1216

Human   181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
            .|:....:.::    .|.||. |:|::|......|||.   ||:........:||.:..|:
Yeast  1217 APETISGSAVK----GKLGAD-DVWALGCVVLEMATGR---RPWSNLDNEWAIMYHVAAGR 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	S_TKc	9..242	CDD:214567	68/256 (27%)
		STKc_TBK1	15..330	CDD:270890	67/250 (27%)
		UBL_TBK1_like	297..385	CDD:240618
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269\|PubMed:21931631	621..729
SSK22	NP_009998.2	STKc_MEKK4	1033..1309	CDD:270796	68/256 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910