Protein Alignment TBK1 and tbk1

DIOPT Version :10

• Sequence 1: NP_037386.1
• Gene: TBK1 / 29110
• HGNCID: 11584
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_001038213.2
• Gene: tbk1 / 692289
• ZFINID: ZDB-GENE-060512-359
• Length: 727
• Species: Danio rerio
• Alignment Length: 728
• Identity: 520/728 - (71%)
• Similarity: 610/728 - (83%)
• Gaps: 4/728 - (0%)

Human     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65
            ||||:|:||::||:|||||||||:||||||||||:|:|||||:|||||:||||||||||||||||
Zfish     1 MQSTANYLWMMSDLLGQGATANVYRGRHKKTGDLYAVKVFNNLSFLRPLDVQMREFEVLKKLNHK 65

Human    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130
            |||||||:|||:.||||||:||:|||||||||||||:|||||||.||||||:|||.|||||||.|
Zfish    66 NIVKLFAVEEESNTRHKVLVMEYCPCGSLYTVLEEPTNAYGLPEDEFLIVLQDVVAGMNHLREYG 130

Human   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195
            ||||||||||||||||:||.|||||||||||||||||||||||||||||||||||||||||||||
Zfish   131 IVHRDIKPGNIMRVIGDDGFSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195

Human   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260
            ||||||||||||||||||||||||||||||||||||||||||||.||.|||||.||.|||.|:||
Zfish   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITEKPPGAISGHQKFENGKIEWS 260

Human   261 GDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIY 325
            .:||:|||||:|||.|||||||||||||||||||||||||||||||||:|::||||||.|.|.:|
Zfish   261 SEMPISCSLSKGLQSLLTPVLANILEADQEKCWGFDQFFAETSDILHRIVVYVFSLQQATLHHVY 325

Human   326 IHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTI 390
            ||:||||.:|.||::::|.|..|:|||:||||||||:|.|.||.||||:.:|||.::.|:|:||:
Zfish   326 IHTYNTANLFQELLFRRTNITPSHQELLYEGRRLVLDPNRQAQTFPKTSRDNPIMLLCRDPVNTV 390

Human   391 GLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYN 455
            ||::|..|.|||.||||||.|||.||...|.|.|..:.:.:|||||||:|||:|.|.|||:|:|:
Zfish   391 GLLFEDPSPPKVQPRYDLDLDASYAKTFAGDVGYLWKTSDSLLLYQELVRKGVRGLNELIRDEYS 455

Human   456 ETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQ 520
            ||:||||||......|.:.:|::.::.|.||:.|:.:||..||.|...|:||||.|..:::.:||
Zfish   456 ETMHKKTEVFHLCSHCSQTLERSEQLCEALMQGNILSAEYDEIRDTRKKVLRLSGSLASMDQTLQ 520

Human   521 DIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKF 585
            ||:|...|||||.|.|..|.||||:||||||::|||:.:..||.|||||||||||.|||||||||
Zfish   521 DINSMFLPGGSLTDTWTQQVGTHPEDRNVEKIKVLLDAIGAIYQQFKKDKAERRLPYNEEQIHKF 585

Human   586 DKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY 650
            |||||..|||||...|||||..||..|::|||||::|..|:||.|||||.|...:|:||:...:.
Zfish   586 DKQKLVLHATKARALFTDECAMKYRLFISKSEEWMKKFHHVRKHLLSLTGQFSSLEQEVTLLMQR 650

Human   651 TNELQETLPQKMFTASSGIKHTMTP-IYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERF 714
            ..:|.|..|||:...:||:   :.| .|.|.:|||||||||||||||||||||||||||..||||
Zfish   651 LYKLLEQFPQKVVPMASGV---LKPQAYLSPSTLVEMTLGMKKLKEEMEGVVKELAENNLFLERF 712

Human   715 GSLTMDGGLRNVD 727
            ||||:|||:|.|:
Zfish   713 GSLTVDGGMRTVE 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	STKc_TBK1	15..330	CDD:270890	278/314 (89%)
		Ubl_TBK1	308..385	CDD:340647	45/76 (59%)
		TBK1_CCD1	400..655	CDD:465742	143/254 (56%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269|PubMed:21931631	621..729		63/108 (58%)
		TBK1_C	678..724	CDD:409263	39/45 (87%)
tbk1	NP_001038213.2	STKc_TBK1	15..330	CDD:270890	278/314 (89%)
		TBK1_ULD	308..395	CDD:465744	51/86 (59%)
		TBK1_CCD1	400..655	CDD:465742	143/254 (56%)
		TBK1_C	676..722	CDD:409263	39/45 (87%)