Protein Alignment TBK1 and Tbk1

DIOPT Version :10

• Sequence 1: NP_037386.1
• Gene: TBK1 / 29110
• HGNCID: 11584
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_062760.3
• Gene: Tbk1 / 56480
• MGIID: 1929658
• Length: 729
• Species: Mus musculus
• Alignment Length: 729
• Identity: 686/729 - (94%)
• Similarity: 712/729 - (97%)
• Gaps: 0/729 - (0%)

Human     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65
            ||||||||||||||||||||||||||||||||||:|:||||||||||||||||||||||||||||
Mouse     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHK 65

Human    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130

Human   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195

Human   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 KKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260

Human   261 GDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIY 325
            ||||:|||||:|||.|||||||||||||||||||||||||||||:||||||||||||.|||||||
Mouse   261 GDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIY 325

Human   326 IHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTI 390
            |||||||.:|||||||||||:||||||||||||||||.||||||||||||||||||.|||.|||:
Mouse   326 IHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSREQLNTV 390

Human   391 GLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYN 455
            ||.||||||||:|||||||||||||||:|||||||||.||||||||||||||:|||:||:|||||
Mouse   391 GLRYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELVKDDYN 455

Human   456 ETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQ 520
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||:|||
Mouse   456 ETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQ 520

Human   521 DIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKF 585
            ||.|||||||.|||.|||||||||:|||||||||||||:||||||||||||||||||||||||||
Mouse   521 DISSRLSPGGLLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKF 585

Human   586 DKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY 650
            |||||||||||||:||::|||:|||||.:|||||:||||||||||||||||||||||||||||:|
Mouse   586 DKQKLYYHATKAMSHFSEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDY 650

Human   651 TNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFG 715
            ||||||||||||..||.|:||.|.|||||||||||||||||||||||||||||||||||||||||
Mouse   651 TNELQETLPQKMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFG 715

Human   716 SLTMDGGLRNVDCL 729
            ||||||||||||||
Mouse   716 SLTMDGGLRNVDCL 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	STKc_TBK1	15..330	CDD:270890	306/314 (97%)
		Ubl_TBK1	308..385	CDD:340647	70/76 (92%)
		TBK1_CCD1	400..655	CDD:465742	233/254 (92%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269|PubMed:21931631	621..729		100/107 (93%)
		TBK1_C	678..724	CDD:409263	45/45 (100%)
Tbk1	NP_062760.3	STKc_TBK1	15..330	CDD:270890	306/314 (97%)
		Ubl_TBK1	308..385	CDD:340647	70/76 (92%)
		TBK1_CCD1	400..655	CDD:465742	233/254 (92%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000250|UniProtKB:Q9UHD2	621..729		100/107 (93%)
		TBK1_C	678..724	CDD:409263	45/45 (100%)