DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBK1 and IKKbeta

DIOPT Version :9

Sequence 1:	NP_037386.1	Gene:	TBK1 / 29110	HGNCID:	11584	Length:	729	Species:	Homo sapiens
Sequence 2:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	178/739 - (24%)
Similarity:	274/739 - (37%)	Gaps:	222/739 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL-KKLN- 63
            |.|..|  |.....||:|....|...|::.||...|.|....:..| ..|.|::..|.. |:||
  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGAL-SADQQVKLSERWNKELNW 62

Human    64 ---HKNIVKLFA---IEEET---------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113
               .||...:.|   ||:..         :.:..|:::|:|..|.:...|:.|.||.||.|.|
  Fly    63 SRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFE-- 125

Human   114 IVLRDVVGGMN---HLREN--GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173
              :|.::|.:.   |...:  ||.|||:||.||:...|.||:.:|||||||.||...|.....|:
  Fly   126 --VRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSV 188

Human   174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238
            .||..|..|::.|...        |.:||||||.||..|...||.|||.|.:   ..|.::..:|
  Fly   189 VGTRHYYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPHQ---TLKNIILNLI 242

Human   239 TGKPSGAISGVQKAE-NGPIDWSGDMPVSCSLSRG-----LQVLLTPVLANILEADQEKCWGFDQ 297
            . ||:..|:..:..| |.......::|.:..|||.     .:.|.:|:.:|..|..|........
  Fly   243 K-KPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPV 306

Human   298 FFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLE 362
            .||:...||:..|:.:|::.            |...:.:.:..:.|.     ::||   ..:||:
  Fly   307 VFADLDKILNMNVLTIFAVN------------NCERLEYAVSAEMTM-----KDLI---ALIVLD 351

Human   363 PGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACR 427
            .|         .:|..::.|                ||..||.          |.||..
  Fly   352 TG---------MDEKELYFV----------------LPTSHPH----------KTITPK------ 375

Human   428 IASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEA 492
             ::.|.||.|      .| .:..||....|......|::.: |.::. |...|:.|.::.|
  Fly   376 -STPLQLYVE------EW-SDTSKDSRKWTKRSNPPVMLYI-FQVKK-ECDYKIPEPILSI---- 426

Human   493 AELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLN 557
                    :..|.:                              |::..|  |:|.::|..||
  Fly   427 --------LSRKFI------------------------------ANKFKT--KERWLQKRVVL-- 449

Human   558 CMTEIYYQFKKDKA----------ERRLAYNEEQ-----IHKFDKQKLYY-HATKAMTHFTDECV 606
               ::.|...|::|          ||.|:..:|.     |...|||::.. .|...:|....|..
  Fly   450 ---DMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLKEAQ 511

Human   607 KKYEA-----------------FLNKSEEWIRKMLH--LR--KQLLSLTNQ-----C----FDIE 641
            .|..:                 |:.:|.:.||..|.  ||  |.::..|||     |    ||..
  Fly   512 AKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCA 576

Human   642 EEVSKY---------QEYTNELQE 656
            ....||         .|..|:.:|
  Fly   577 RFYKKYLCNGAIISPSELNNDAEE 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	S_TKc	9..242	CDD:214567	83/254 (33%)
		STKc_TBK1	15..330	CDD:270890	102/342 (30%)
		UBL_TBK1_like	297..385	CDD:240618	15/87 (17%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269\|PubMed:21931631	621..729		16/58 (28%)
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	83/254 (33%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	99/319 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810