Protein Alignment TBK1 and Tbk1

DIOPT Version :10

• Sequence 1: NP_037386.1
• Gene: TBK1 / 29110
• HGNCID: 11584
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_001100256.1
• Gene: Tbk1 / 299827
• RGDID: 1588588
• Length: 729
• Species: Rattus norvegicus
• Alignment Length: 729
• Identity: 689/729 - (94%)
• Similarity: 713/729 - (97%)
• Gaps: 0/729 - (0%)

Human     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65
            ||||||||||||||||||||||||||||||||||:|:||||||||||||||||||||||||||||
  Rat     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHK 65

Human    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130

Human   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195

Human   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 KKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260

Human   261 GDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIY 325
            ||||:|||||:|||.|||||||||||||||||||||||||||||:||||||||||||.|||.|||
  Rat   261 GDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTALKIY 325

Human   326 IHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTI 390
            |||||||.:||||||||||||||||||||||||||||.||||||||||||||||||.|||.||:|
  Rat   326 IHSYNTAAVFHELVYKQTKIISSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSREQLNSI 390

Human   391 GLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYN 455
            ||.||||||||:|||||||||||||||:|||||||||.|.||||||||||||:||||||:|||||
  Rat   391 GLRYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTAGTLLLYQELMRKGVRWLIELVKDDYN 455

Human   456 ETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQ 520
            ||||||||||||||||||||||||||||||||::|:|||||||||||||||||||||||||:|||
  Rat   456 ETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVSLDAAELGEISDIHTKLLRLSSSQGTIESSLQ 520

Human   521 DIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKF 585
            ||:|||||||||||.|||||||||:|||||||||||||:||||||||||||||||||||||||||
  Rat   521 DINSRLSPGGSLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKF 585

Human   586 DKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY 650
            |||||||||||||||||||||:|||||.:.||||:||||||||||||||||||||||||||||:|
  Rat   586 DKQKLYYHATKAMTHFTDECVRKYEAFKDTSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDY 650

Human   651 TNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFG 715
            ||||||||||||..||||||||:.|||||||||||||||||||||||||||||||||||||||||
  Rat   651 TNELQETLPQKMLAASSGIKHTVAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFG 715

Human   716 SLTMDGGLRNVDCL 729
            ||||||||||||||
  Rat   716 SLTMDGGLRNVDCL 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	STKc_TBK1	15..330	CDD:270890	305/314 (97%)
		Ubl_TBK1	308..385	CDD:340647	70/76 (92%)
		TBK1_CCD1	400..655	CDD:465742	234/254 (92%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269|PubMed:21931631	621..729		102/107 (95%)
		TBK1_C	678..724	CDD:409263	45/45 (100%)
Tbk1	NP_001100256.1	STKc_TBK1	15..330	CDD:270890	305/314 (97%)
		Ubl_TBK1	308..385	CDD:340647	70/76 (92%)
		TBK1_CCD1	400..655	CDD:465742	234/254 (92%)
		TBK1_C	678..724	CDD:409263	45/45 (100%)