DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBK1 and mek1

DIOPT Version :9

Sequence 1:	NP_037386.1	Gene:	TBK1 / 29110	HGNCID:	11584	Length:	729	Species:	Homo sapiens
Sequence 2:	NP_594908.1	Gene:	mek1 / 2541604	PomBaseID:	SPAC14C4.03	Length:	445	Species:	Schizosaccharomyces pombe

Alignment Length:	346	Identity:	81/346 - (23%)
Similarity:	149/346 - (43%)	Gaps:	84/346 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL-------- 70
            :||.|..:.::......||..:|.|:.:..........:..|..:|:||:|.||:|:
pombe   165 LLGIGGFSRIYMAMDNNTGGQYACKIIDKKKISTKRFFEDHEMTILRKLDHPNIIKVNMEYNSET 229

Human    71 -FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134
             |.|.||..|.           |.|::.|.:...   :||...|.::..::.|:.:|.|..|:||
pombe   230 QFFIFEEMVTG-----------GDLFSYLTKLGT---VPEVTTLFIMFQILQGLKYLHEQNIIHR 280

Human   135 DIKPGNIMRVIGEDGQSVYK--LTDFGAARELEDDEQFVSLYGTEEYLHPDMYE---RAVLRKDH 194
            |:|..||:  |.....::::  |||||.||.::..::..:..||.||..|::..   |:.:.|::
pombe   281 DLKLENIL--IASSSDTIFRIILTDFGVARCMQKGKRLSTFVGTPEYTAPEIQRLKGRSQVEKEN 343

Human   195 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDW 259
            ...||..|||||:||                       :|:.:::|.......||::.:   :|:
pombe   344 SSGYGKEVDLWSLGV-----------------------IMFLLLSGNSPSFADGVKEKQ---VDF 382

Human   260 SGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKI 324
            ..  ||..|:||..:.|    ::|:|:.:..     |:                |:::|..:|..
pombe   383 RD--PVWKSVSRQAKDL----ISNLLKTNPP-----DR----------------FTVKQCLSHPW 420

Human   325 YI-HSYNTATIFHELVYKQTK 344
            :. ||.....::...:.|..|
pombe   421 FARHSSRLTKLYETRILKPLK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	S_TKc	9..242	CDD:214567	62/241 (26%)
		STKc_TBK1	15..330	CDD:270890	79/329 (24%)
		UBL_TBK1_like	297..385	CDD:240618	7/49 (14%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269\|PubMed:21931631	621..729
mek1	NP_594908.1	FHA	39..141	CDD:238017
		STKc_CAMK	163..420	CDD:270687	77/323 (24%)
		S_TKc	164..421	CDD:214567	77/324 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910