Protein Alignment TBK1 and Y39G8B.5

DIOPT Version :10

• Sequence 1: NP_037386.1
• Gene: TBK1 / 29110
• HGNCID: 11584
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_496929.2
• Gene: Y39G8B.5 / 189764
• WormBaseID: WBGene00012726
• Length: 726
• Species: Caenorhabditis elegans
• Alignment Length: 787
• Identity: 166/787 - (21%)
• Similarity: 296/787 - (37%)
• Gaps: 225/787 - (28%)

Human     3 STSNHLWLL--SDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKKLNH 64
            ||...::.|  .:.:.:||.:.|:||| .::|.|.|:|.. ...|....||....|.::||||..
 Worm    13 STDGEMYTLYNDEFMAKGAYSQVYRGR-TESGRLVAVKTARKTASNKADVDAMCTEIDILKKLKG 76

Human    65 -KNIVKLFAIEEETTTRHKVLI------MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122
             .|||:.|..:........|.|      || |...||...:..|.|..|||.:..:.::.|....
 Worm    77 VANIVQYFGSKNTKIPPGSVTIETISFAME-CASRSLDAEMRRPENHKGLPSNVLIDLVVDCSMA 140

Human   123 MNHLRENGIVHRDIK-------PGNIMRVIGEDGQSVYKLTDFGAARELEDD--EQFVSLYGTEE 178
            ::.|||:.|.|||||       ||:..|  |.....::||.|.|.::.:.::  ::..|:.||:.
 Worm   141 LSALREHNIAHRDIKHMNILLFPGSPTR--GRRSTHLFKLCDMGCSKAISENSSQELNSIAGTKT 203

Human   179 YLHPDMYERAVLRKDHQKKYGAT-----VDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI- 237
            :|:||    .:....|..|..:.     .||||:|.|.|..|||..   |||..|.:..:.:..
 Worm   204 FLYPD----HIPPNGHNWKTKSAYTPEQCDLWSLGCTLYFCATGEF---PFESTRADANLYHMAA 261

Human   238 --ITGKPSGAISGVQKAEN----------GPIDWSGDMPVSCS-LSRGLQVLLTPVLANILEADQ 289
              :|..|:.....:.:.||          .|:.   ::|...: ..:.|...:|.:|.|......
 Worm   262 VDLTRNPNAVAVNLVQVENPVTKEKVFNFEPVT---ELPAEFTRYPKWLVCTMTCLLRNFFHEPS 323

Human   290 EKCWGFDQFFAETSDILHRMVIHVF-SLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELI 353
                  .:::|:.:.::.......| |:.||:   |..|: :.:.|.      ::.:.|.::.|.
 Worm   324 ------IEYYAKVAGVMRNSKRRTFASVDQMS---IVEHT-DMSNIL------ESSLPSISECLG 372

Human   354 Y-EGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKA 417
            | ||..:||                                     |......| ||   |..|:
 Worm   373 YPEGIDIVL-------------------------------------LANTSTHY-LD---SKQKS 396

Human   418 ITGVV--CYACRIASTLLLYQELMRKGIRW----------LIEL-IKDDYNETVHKKTEVVITLD 469
            :.|:.  .|.....::.:..:.|:::.|::          |||: ||..| |.:...|||...||
 Worm   397 VDGLPDDLYLVLPQTSQVEMRTLLKRNIKFNELECMTDTKLIEIRIKKCY-EGLSMLTEVDEYLD 460

Human   470 FCIRNIEKTVKVYEKLMKI-----NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPG 529
                       :::::..|     :|...||.:...:.|      :|:..:...:..:...|.
 Worm   461 -----------LFDRVSAILSTQFSLLVQELSQFERVQT------TSRFAVYVDMASVPMMLF-- 506

Human   530 GSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHA 594
                           .:.|.|...:...|:.:....                     :::|..||
 Worm   507 ---------------DEANPEAKTIADQCIQQAIQA---------------------REELERHA 535

Human   595 TKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKY-----------Q 648
            ..||..  :.|.||    |::..|      .||.:.:.|..    |..|:..|           |
 Worm   536 KVAMDF--EACAKK----LSREAE------DLRLEDMDLPG----IRREIESYLFYDKATILSTQ 584

Human   649 EYTNELQE-------TLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAE 706
            :||.||.|       |:.:::|.:..||..:      ..||.:.:...:.:|:.:.:.:...::|
 Worm   585 KYTQELVELCLKRRNTVMKQIFNSPDGINKS------KLNTAMNLAASLSQLRSDYQKLQDMISE 643

Human   707 NNHILER 713
            ...:||:
 Worm   644 CVDLLEK 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	STKc_TBK1	15..330	CDD:270890	91/351 (26%)
		Ubl_TBK1	308..385	CDD:340647	14/78 (18%)
		TBK1_CCD1	400..655	CDD:465742	51/283 (18%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269|PubMed:21931631	621..729		22/111 (20%)
		TBK1_C	678..724	CDD:409263	6/36 (17%)
Y39G8B.5	NP_496929.2	Protein Kinases, catalytic domain	25..263	CDD:473864	74/248 (30%)