Protein Alignment TBK1 and tbk1

DIOPT Version :10

• Sequence 1: NP_037386.1
• Gene: TBK1 / 29110
• HGNCID: 11584
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_001135652.1
• Gene: tbk1 / 100216212
• XenbaseID: XB-GENE-955452
• Length: 725
• Species: Xenopus tropicalis
• Alignment Length: 729
• Identity: 548/729 - (75%)
• Similarity: 639/729 - (87%)
• Gaps: 4/729 - (0%)

Human     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65
            ||||:||||||||||||||||||:|||:||||||:|:|||||:|||||.||||||||||||||||
 Frog     1 MQSTANHLWLLSDILGQGATANVYRGRNKKTGDLYAVKVFNNLSFLRPADVQMREFEVLKKLNHK 65

Human    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130
            |||||||||||.::|||||:||||||.|||:|||||:|||||||||||||.||||.|||||||||
 Frog    66 NIVKLFAIEEEMSSRHKVLVMEFCPCASLYSVLEEPANAYGLPESEFLIVSRDVVAGMNHLRENG 130

Human   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195
            |:||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||:||
 Frog   131 IIHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELDDDEQFVSLYGTEEYLHPDMYERAVLRKEHQ 195

Human   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260
            |||||||||||||||||||||||||||||||||||||||||||.|||||||||||:||||||:||
 Frog   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIAGKPSGAISGVQRAENGPIEWS 260

Human   261 GDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIY 325
            |::||:|:||.|||.|.||||||||||||||||||:||||.|:|:.:|:|||||||||||.||||
 Frog   261 GELPVTCNLSMGLQTLFTPVLANILEADQEKCWGFEQFFAVTNDVFNRIVIHVFSLQQMTPHKIY 325

Human   326 IHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTI 390
            |::|:....||:||||||||.:.||||::||||||||.||||||||.|||||||||::||.::.|
 Frog   326 INTYDKVPDFHDLVYKQTKIPAQNQELLFEGRRLVLEQGRLAQHFPITTEENPIFVLTREMVSVI 390

Human   391 GLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYN 455
            ||.:::|.:||:|..||||.||:||||:|||.||.||||::|||..||||||||||.|::|::||
 Frog   391 GLRFDEIVIPKLHSHYDLDVDANMAKAVTGVACYYCRIAASLLLVLELMRKGIRWLSEILKEEYN 455

Human   456 ETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQ 520
            |.||:.|||.:.|.||.|.|||.:|.||:|::.::|.    |:..||.|||.|||:|.::::|||
 Frog   456 ENVHRNTEVSLKLSFCNRTIEKDLKTYEQLIQTSVEP----EVYVIHGKLLNLSSTQESLKSSLQ 516

Human   521 DIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKF 585
            :|.::|:|||.|.|:|.:.||||..|||||||||||:.:||||.|||||||:|||.|||||||||
 Frog   517 EIKNKLTPGGVLMDSWINAEGTHSADRNVEKLQVLLSLITEIYCQFKKDKAQRRLLYNEEQIHKF 581

Human   586 DKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY 650
            ||||:..|:|||.:.|.||||.|||.|.:|:.:|:|||:|:||||.||.:|||:|||||||.|.|
 Frog   582 DKQKMCIHSTKAYSLFKDECVGKYEGFRSKALDWMRKMIHVRKQLFSLKSQCFEIEEEVSKCQHY 646

Human   651 TNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFG 715
            .|:.||.:..|||.|..|||..:.|||.|.||||||||||:||||:||||||||.||||||||||
 Frog   647 INQYQEKMSPKMFAAPGGIKSAVNPIYSSPNTLVEMTLGMRKLKEDMEGVVKELEENNHILERFG 711

Human   716 SLTMDGGLRNVDCL 729
            :||:|||.|||||:
 Frog   712 ALTIDGGFRNVDCI 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBK1	NP_037386.1	STKc_TBK1	15..330	CDD:270890	276/314 (88%)
		Ubl_TBK1	308..385	CDD:340647	57/76 (75%)
		TBK1_CCD1	400..655	CDD:465742	158/254 (62%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269|PubMed:21931631	621..729		77/107 (72%)
		TBK1_C	678..724	CDD:409263	38/45 (84%)
tbk1	NP_001135652.1	STKc_TBK1	15..330	CDD:270890	276/314 (88%)
		Ubl_TBK1	308..385	CDD:340647	57/76 (75%)
		TBK1_CCD1	400..651	CDD:465742	158/254 (62%)
		TBK1_C	674..720	CDD:409263	38/45 (84%)