DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRM1 and mGluR

DIOPT Version :10

Sequence 1:NP_001264993.1 Gene:GRM1 / 2911 HGNCID:4593 Length:1194 Species:Homo sapiens
Sequence 2:NP_524639.2 Gene:mGluR / 43838 FlyBaseID:FBgn0019985 Length:976 Species:Drosophila melanogaster


Alignment Length:950 Identity:369/950 - (38%)
Similarity:541/950 - (56%) Gaps:117/950 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    21 RSPGRKVLLAGASSQRSVA-RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFH 84
            :||      :...:|.||: .:.||:|:|.||.||     ||.....||......|:||:|||.:
  Fly    26 KSP------SNTHTQDSVSVSLPGDIILGGLFPVH-----EKGEGAPCGPKVYNRGVQRLEAMLY 79

Human    85 TLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQS--L 147
            .:|::|.||.:||.||:|..|.|:|...:.||.||::|:|.||.::  :..|. .| .||.|  |
  Fly    80 AIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNL--DTSGY-EC-ADGSSPQL 140

Human   148 PPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQA 212
            ....:..|:.||||...|||::||.|||:||.|||::.::|:..|||||.:..|.|.||.||.|:
  Fly   141 RKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQS 205

Human   213 RAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKL 277
            .|::||:|.:||:|||.:|:||:|||.|::|..:.|.:..:|||.::|:.|.|.:|.||.::.||
  Fly   206 VALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKL 270

Human   278 RERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKL 342
            ::: |.||.||.|......|.:|.|.:|..:...|..|.||||..:.:::||.|..|.|.||::|
  Fly   271 QKK-PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVEL 334

Human   343 QSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPN---------------FKR 392
            ||..:..||.|.::|..:||.|||||.|:|:..|.|.|.. |...|:               .|.
  Fly   335 QSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTS-LSVKPDTSNSANSTDNKIGVKAKT 398

Human   393 ICTGNESLEE--NYVQDSKMGFVINAIYAMAHGLQNMHHALC----------PGHV--------- 436
            .|..:..|.|  .|.|:||..||::|:||.|:.|.|:|:..|          ..|:         
  Fly   399 ECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRK 463

Human   437 -------GLCDAMKPIDGSKLL-DFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTE-ANRY 492
                   ..|..|...||.:.. ::|:..|||.::|.||.||.:||...||||:|.|..| ::.|
  Fly   464 ISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGY 528

Human   493 DYVHVGTWHEGVLNIDDYKIQMNKSGVV--------RSVCSEPCLKGQIKVIRKGEVSCCWICTA 549
            .|..:|.|..|        :|:|...||        .|.||.||..|.||. ::|: :|||||.:
  Fly   529 QYKVIGKWFNG--------LQLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGD-TCCWICDS 583

Human   550 CKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIF 614
            |:..|||.||||||.|..|.||.||...|..:.::|::|:::.::|.:|.:..||.:|..|.::|
  Fly   584 CESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLF 648

Human   615 VLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKT 679
            ....|||:|::|.|||.|.:|.||.:.|...|.||||||..||.|||..:|:..::.||||:|||
  Fly   649 AKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKT 713

Human   680 NRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYL 744
            |||:||...:.|.  .::.:::|..:||:|.:.||::|:.:.:..:::|||.....||..:||.|
  Fly   714 NRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVIL 776

Human   745 ICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--G 807
            .|...::..:....||.:||..||.||.|||.:|.||||:|:|.||||||||||||||||||  |
  Fly   777 KCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTG 841

Human   808 SNYKIITT--CFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSN 870
            ::|::.||  |.::|||.:|||.|:::||:||::..|::|||                ||...| 
  Fly   842 NSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVR----------------KLTMNS- 889

Human   871 TFLNIFRRKKAGA--GNANSNGKSVSWSEPG-----GGQV 903
               .::||..|..  |...|:|.|.:.: ||     ||.|
  Fly   890 ---TVYRRSAAAVAQGAPTSSGYSRTHA-PGTSALTGGAV 925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRM1NP_001264993.1 PBP1_mGluR_groupI 36..510 CDD:380597 196/521 (38%)
NCD3G 521..571 CDD:462210 26/49 (53%)
7tmC_mGluR1 591..840 CDD:320565 114/252 (45%)
TM helix 1 591..616 CDD:320565 7/24 (29%)
TM helix 2 628..649 CDD:320565 9/20 (45%)
TM helix 3 658..682 CDD:320565 12/23 (52%)
TM helix 4 706..726 CDD:320565 6/19 (32%)
TM helix 5 749..775 CDD:320565 9/25 (36%)
TM helix 6 783..806 CDD:320565 19/22 (86%)
TM helix 7 809..834 CDD:320565 11/26 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 883..905 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1173
GluR_Homer-bdg 1144..1194 CDD:431390
mGluRNP_524639.2 PBP1_mGluR_groupII 39..542 CDD:380598 194/521 (37%)
NCD3G 556..605 CDD:462210 26/50 (52%)
7tmC_mGluRs_group2_3 625..876 CDD:320600 114/252 (45%)
TM helix 1 625..650 CDD:320600 7/24 (29%)
TM helix 2 662..683 CDD:320600 9/20 (45%)
TM helix 3 692..716 CDD:320600 12/23 (52%)
TM helix 4 738..758 CDD:320600 6/19 (32%)
TM helix 5 781..807 CDD:320600 9/25 (36%)
TM helix 6 815..838 CDD:320600 19/22 (86%)
TM helix 7 845..870 CDD:320600 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

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