DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRM1 and mgl-2

DIOPT Version :10

Sequence 1:NP_001264993.1 Gene:GRM1 / 2911 HGNCID:4593 Length:1194 Species:Homo sapiens
Sequence 2:NP_492720.3 Gene:mgl-2 / 172914 WormBaseID:WBGene00003233 Length:1035 Species:Caenorhabditis elegans


Alignment Length:1014 Identity:387/1014 - (38%)
Similarity:574/1014 - (56%) Gaps:91/1014 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    33 SSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLP 97
            |::..||.:.|::.|||||.:|.|....:    .||||.|||||||.|....|:.::|.:   ||
 Worm    25 SARMLVAEIHGEIQIGALFPIHRQIAGSE----SCGEIWEQYGIQRSEIAMLTVKQLNEE---LP 82

Human    98 NITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKK--PIAGVI 160
             ..||..||||||...:|:||:|.|:|          :|:.:|   .....||..||  |:..||
 Worm    83 -FKLGLSIRDSCWTERIAMEQTIAFLR----------EGVAQC---SCCQTPGCNKKSVPVVAVI 133

Human   161 GPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWT 225
            |||.||..|.||||||:|.|||:.||||:.|||||..:.|||||||||..||:|:..::..||||
 Worm   134 GPGKSSSTIAVQNLLQVFRIPQVGYSATTPDLSDKEQFGYFLRVVPSDVFQAQAINRLLHHYNWT 198

Human   226 YVSAVHTEGNYGESGMDAFKELAA--QEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVV 288
            ||:.:::.|||||.|.::.::|.|  ...:|||:|:||.:.|.|:.:.::|.:|..:..:.:|||
 Worm   199 YVAVLYSAGNYGEKGFESLEKLIAHRSSSVCIAYSEKIKTLASEQEYRQVLTRLDSQNSRPQVVV 263

Human   289 CFCEGMTVRGLLSAMRRLG----VVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRS 349
            |||||.::|....|.:.|.    .:..|..|||||||||::|:|..|.||.|..:|::.:|::..
 Worm   264 CFCEGASMRMFFKAQKHLADGKMQMKRFQWIGSDGWADRNDVVEDLEEEAEGSFSIRIHAPKIPG 328

Human   350 FDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFK-RICTGNESLEENYVQDSKMGFV 413
            |..|:..|..:.||.||||.||||.:|.|:......:..|.. |||:|:|:|:|.|.:|.|:..|
 Worm   329 FRQYYTALHPENNTMNPWFREFWQQKFNCQFAVSKEDKNNENIRICSGDENLDEQYKEDPKLSQV 393

Human   414 INAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGR 478
            ||:|..:|.||:.|:...|..:..||..|...:|:.|.::|:..::.....:.|:||..||.|..
 Worm   394 INSIRVVALGLKAMYQDRCRDNSTLCTEMLSRNGTLLYEYLLNVTYSDQFKQPVYFDRNGDPPAW 458

Human   479 YDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQ----------MNKSGVV-RSVCSEPCLKGQ 532
            |||:|...|:.....|..||::.    :|:||.::          .:|:.:: .||||.||..||
 Worm   459 YDILNYIGTKDLDNPYNEVGSFK----SINDYGVEELDMTAKSMFFDKTELLPESVCSRPCGIGQ 519

Human   533 IKVIRKGE-VSCCWICTACKENEYVQDEFT-CKACDLGWWPNADLTGCEPIPVRYLEWSNIESII 595
                |:.| ::|||||.:|.:.:||..... |..|.||.||||:.||||.|....:.|::...|:
 Worm   520 ----RQRETMACCWICESCLDIQYVNKTTNQCMNCTLGSWPNANRTGCEYIIPEVVSWTSFGHIL 580

Human   596 AIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ 660
            |:..:..||:.::....:|:.:..||||||::|||.||||:|:...|...|.|:|.|:||||::.
 Worm   581 ALVLAVTGIITSMATLAVFLRHNSTPVVKSTTRELSYIILSGLVACYAVSFALLATPSTTSCFIT 645

Human   661 RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLV-VTL 724
            |::..::.|:.||||:|||||||||||||||:|.|:||||::.::||:|..||::||..:| |.|
 Worm   646 RVIPPIAFAVVYSALLTKTNRIARILAGSKKRILTKKPRFLTTFSQVVITWILVAVQCVIVGVGL 710

Human   725 IIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAF 789
            :...|......|...:::.|.|:|.....:.|..::..||..||.|||||||:|.||||||:|.|
 Worm   711 MRDWPDATYAKYALPRKLILECDTETKSFLIPFFWDFFLITLCTLYAFKTRNLPENFNEAKFIGF 775

Human   790 TMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSD 854
            |||.|.::|:||:.::.|:.:|.:...|:.|||.:|||..:|.||:|||:..||:|:|:::||:.
 Worm   776 TMYCTVVVWIAFLVLHMGTTHKALVMSFSYSLSASVALALLFFPKLYIILMHPEKNIRASYTTTK 840

Human   855 VVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHV-- 917
            ::|.|.|:.:....|.:.......|.....:..|...|.| |..|||       :....||||  
 Worm   841 LIRCHFGNSQAAYDSTSKQQHLGSKTTARTSVQSGSASKS-SSMGGG-------VTRTASVHVPV 897

Human   918 ---KTNET-ACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYN------------------VEEE 960
               .|:.| ...||......::|:...|:.....|...:.|.:                  :||.
 Worm   898 SRGSTHSTDVSTQTEAASKFSRSFSIVGRKKQGLDDDVQQLVDACRRYQDEKINSSAANLLLEES 962

Human   961 ED------AQPIRFSPPGSPSMVVHRR-VPSAATTPPLP 992
            ||      |..|..|.....|.|..:. ||.....|.:|
 Worm   963 EDEVGALLADSIENSMRTVLSTVAGKAVVPLVPMVPMIP 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRM1NP_001264993.1 PBP1_mGluR_groupI 36..510 CDD:380597 195/482 (40%)
NCD3G 521..571 CDD:462210 22/51 (43%)
7tmC_mGluR1 591..840 CDD:320565 113/249 (45%)
TM helix 1 591..616 CDD:320565 5/24 (21%)
TM helix 2 628..649 CDD:320565 10/20 (50%)
TM helix 3 658..682 CDD:320565 10/23 (43%)
TM helix 4 706..726 CDD:320565 10/20 (50%)
TM helix 5 749..775 CDD:320565 9/25 (36%)
TM helix 6 783..806 CDD:320565 12/22 (55%)
TM helix 7 809..834 CDD:320565 9/24 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 883..905 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1173
GluR_Homer-bdg 1144..1194 CDD:431390
mgl-2NP_492720.3 Periplasmic_Binding_Protein_type1 28..482 CDD:471960 194/478 (41%)
NCD3G 507..556 CDD:462210 22/52 (42%)
7tmC_mGluR_group1 576..826 CDD:320412 113/249 (45%)
TM helix 1 576..601 CDD:320412 5/24 (21%)
TM helix 2 613..634 CDD:320412 10/20 (50%)
TM helix 3 643..667 CDD:320412 10/23 (43%)
TM helix 4 691..711 CDD:320412 9/19 (47%)
TM helix 5 735..761 CDD:320412 9/25 (36%)
TM helix 6 769..792 CDD:320412 12/22 (55%)
TM helix 7 795..820 CDD:320412 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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