Protein Alignment GRM1 and Grm1

DIOPT Version :10

• Sequence 1: NP_001264993.1
• Gene: GRM1 / 2911
• HGNCID: 4593
• Length: 1194
• Species: Homo sapiens
• Sequence 2: NP_058672.1
• Gene: Grm1 / 14816
• MGIID: 1351338
• Length: 1199
• Species: Mus musculus
• Alignment Length: 1202
• Identity: 1130/1202 - (94%)
• Similarity: 1159/1202 - (96%)
• Gaps: 11/1202 - (0%)

Human     1 MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPER 65
            ||.|||.|||.||||:|:|||.|.|||||||||||||||||||||||||||||||||||||||||
Mouse     1 MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPER 65

Human    66 KCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISI 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 KCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISI 130

Human   131 RDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK 195
            ||||||:||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 RDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK 195

Human   196 TLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 TLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDK 260

Human   261 IYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDE 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 IYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDE 325

Human   326 VIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNF 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 VIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNF 390

Human   391 KRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI 455
            |::|||||||||||||||||||||||||||||||||||||||||:||||||||||||.|||||||
Mouse   391 KKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVGLCDAMKPIDGRKLLDFLI 455

Human   456 KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVV 520
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse   456 KSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMV 520

Human   521 RSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRY 585
            ||||||||||||||||||||||||||||||||||:|||||||:||||||||||:|||||||.:||
Mouse   521 RSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPITIRY 585

Human   586 LEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIA 650
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 LEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIA 650

Human   651 KPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILIS 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 KPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILIS 715

Human   716 VQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN 780
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   716 VQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPAN 780

Human   781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERN 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERN 845

Human   846 VRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMW 910
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||.|.|||||:|
Mouse   846 VRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVW 910

Human   911 HRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPS 975
            .|||||||||||||||||||||||||||||||||||||.|||||||||||::.....||||.|||
Mouse   911 QRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPSSPS 975

Human   976 MVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPL-QQQQQPPP-----QQKSLMDQL 1034
            ||||||.|..|||||||.||:|||||||||:..:|||||||| ||||||||     |.|||||||
Mouse   976 MVVHRRGPPVATTPPLPPHLSAEETPLFLADSVIPKGLPPPLPQQQQQPPPQPPPQQPKSLMDQL 1040

Human  1035 QGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDD 1099
            ||||:||.:.||||||||||||.||||||||||||||||||||||||||||.||.:|||.:||||
Mouse  1041 QGVVTNFGSGIPDFHAVLAGPGTPGNGLRSLYPPPPPPQHLQMLPLQLSTFREEPISPPGEDDDD 1105

Human  1100 --SERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVP 1162
              |||||||||:||  |||||||||:| ||||||.|||||||:||||||||||||||||||||||
Mouse  1106 DSSERFKLLQEFVY--EREGNTEEDDL-EEEEDLPAASKLTPEDSPALTPPSPFRDSVASGSSVP 1167

Human  1163 SSPVSESVLCTPPNVSYASVILRDYKQSSSTL 1194
            |||||||||||||||:||||||||||||||||
Mouse  1168 SSPVSESVLCTPPNVTYASVILRDYKQSSSTL 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM1	NP_001264993.1	PBP1_mGluR_groupI	36..510	CDD:380597	466/473 (99%)
		NCD3G	521..571	CDD:462210	47/49 (96%)
		7tmC_mGluR1	591..840	CDD:320565	247/248 (100%)
		TM helix 1	591..616	CDD:320565	24/24 (100%)
		TM helix 2	628..649	CDD:320565	20/20 (100%)
		TM helix 3	658..682	CDD:320565	23/23 (100%)
		TM helix 4	706..726	CDD:320565	19/19 (100%)
		TM helix 5	749..775	CDD:320565	24/25 (96%)
		TM helix 6	783..806	CDD:320565	22/22 (100%)
		TM helix 7	809..834	CDD:320565	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..905		19/21 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1030		18/28 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1113..1173		54/59 (92%)
		GluR_Homer-bdg	1144..1194	CDD:431390	48/49 (98%)
Grm1	NP_058672.1	PBP1_mGluR_groupI	36..510	CDD:380597	466/473 (99%)
		NCD3G	521..571	CDD:462210	47/49 (96%)
		7tmC_mGluR1	591..840	CDD:320565	247/248 (100%)
		TM helix 1	591..616	CDD:320565	24/24 (100%)
		TM helix 2	628..649	CDD:320565	20/20 (100%)
		TM helix 3	658..682	CDD:320565	23/23 (100%)
		TM helix 4	706..726	CDD:320565	19/19 (100%)
		TM helix 5	749..775	CDD:320565	24/25 (96%)
		TM helix 6	783..806	CDD:320565	22/22 (100%)
		TM helix 7	809..834	CDD:320565	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..906		21/23 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	959..1035		51/75 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1055..1082		25/26 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1177		55/61 (90%)
		GluR_Homer-bdg	1149..1199	CDD:431390	48/49 (98%)