Protein Alignment GRM1 and grm1

DIOPT Version :10

• Sequence 1: NP_001264993.1
• Gene: GRM1 / 2911
• HGNCID: 4593
• Length: 1194
• Species: Homo sapiens
• Sequence 2: XP_017949676.2
• Gene: grm1 / 100495945
• XenbaseID: XB-GENE-980107
• Length: 1172
• Species: Xenopus tropicalis
• Alignment Length: 1201
• Identity: 938/1201 - (78%)
• Similarity: 1027/1201 - (85%)
• Gaps: 50/1201 - (4%)

Human     1 MVGLLLFFFPAIFLEV---SLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKV 62
            ||.|||.....:.|::   .|.    ||...|..|||.|||||||||:|||||||||||||||||
 Frog    15 MVNLLLILMMTVGLDIFYGGLF----GRNTFLVCASSPRSVARMDGDIIIGALFSVHHQPPAEKV 75

Human    63 PERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSL 127
            |||||||||||||||||||||||||:||.|..||||||||:||||||||||||||||||||||||
 Frog    76 PERKCGEIREQYGIQRVEAMFHTLDQINMDQNLLPNITLGTEIRDSCWHSSVALEQSIEFIRDSL 140

Human   128 ISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDL 192
            ||:||||||..:|| |....|.||.||||||||||||||||||||||||||||||||||||||||
 Frog   141 ISMRDEKDGAGKCL-DATPTPHGRIKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDL 204

Human   193 SDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAH 257
            ||||||||||||||||.||||||||||||||||||||||||||||||||:||||:||||||||||
 Frog   205 SDKTLYKYFLRVVPSDILQARAMLDIVKRYNWTYVSAVHTEGNYGESGMEAFKEMAAQEGLCIAH 269

Human   258 SDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWAD 322
            :|||||||||::|||||:||||||||||||:||||||||||:|.|||||||.|||.|||||||||
 Frog   270 TDKIYSNAGERNFDRLLKKLRERLPKARVVICFCEGMTVRGILMAMRRLGVAGEFLLIGSDGWAD 334

Human   323 RDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLEN 387
            |||||||||.|||||||:||||.||.|||.|:|.||||||:|||||.||||||||||:|||..||
 Frog   335 RDEVIEGYEAEANGGITMKLQSAEVMSFDTYYLGLRLDTNSRNPWFTEFWQHRFQCRIPGHPQEN 399

Human   388 PNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLD 452
            .:||:||.|||:|||||||||||||||||||||||||.:||.||||||||||||||||||||||:
 Frog   400 RSFKKICKGNETLEENYVQDSKMGFVINAIYAMAHGLHDMHSALCPGHVGLCDAMKPIDGSKLLE 464

Human   453 FLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKS 517
            ||||:||:|:|||:|||||||||||||||||||..|.||||||.:|.||||:|::|||:||.|||
 Frog   465 FLIKASFLGISGEDVWFDEKGDAPGRYDIMNLQQIEPNRYDYVQIGAWHEGILSMDDYRIQANKS 529

Human   518 GVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIP 582
            |:||||||:||.||:||||||||||||||||.|||||:|||||||||||.|.|||..||||||||
 Frog   530 GIVRSVCSDPCSKGEIKVIRKGEVSCCWICTPCKENEFVQDEFTCKACDQGAWPNPGLTGCEPIP 594

Human   583 VRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFT 647
            |:||:||:||||||:||||||||:|:||||||:|||||||||||||||||||||||||||:||||
 Frog   595 VKYLQWSDIESIIAVAFSCLGILITMFVTLIFILYRDTPVVKSSSRELCYIILAGIFLGYICPFT 659

Human   648 LIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASI 712
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||:||||
 Frog   660 LIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSACAQVVIASI 724

Human   713 LISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNV 777
            |||:||:|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   725 LISLQLSLVVSLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNV 789

Human   778 PANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKP 842
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
 Frog   790 PANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTSFAVSLSVTVALGCMFTPKMYIIIAKP 854

Human   843 ERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQ 907
            ||||||||||||||||||||||.||||||||:||||||...||.||||||||||||||.||.|||
 Frog   855 ERNVRSAFTTSDVVRMHVGDGKTPCRSNTFLSIFRRKKPSTGNTNSNGKSVSWSEPGGRQVQKGQ 919

Human   908 HMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSP-P 971
            |||||||||||:.||..|||||||||||.||...||||||||||.||||||||::.:..||:. .
 Frog   920 HMWHRLSVHVKSKETGSNQTAVIKPLTKGYQAQNKSLTFSDTSTNTLYNVEEEDENETGRFNAMM 984

Human   972 GSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQG 1036
            .||:.::|||:.|   ||| ||. ..:|..::|:|            |..:..|.|||::|||.|
 Frog   985 SSPTSIIHRRLNS---TPP-PSQ-EFDEGSMYLSE------------QVSKSLPLQKSIIDQLHG 1032

Human  1037 VVSNFSTAIPDFHAVLAGPG---GPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDD 1098
            |:..|||.|||.::|:..||   |.|:.|.|.:|      ..|:||.|.:||.|.:..|..
 Frog  1033 VIDRFSTGIPDLNSVVPMPGTENGVGSTLSSKHP------QQQVLPFQTATFNEGMDLPAV---- 1087

Human  1099 DSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPS 1163
            |.|:..|:..|:|          |..:..:|:| .::||..:||||||||||||||||||||:.|
 Frog  1088 DCEKLNLIHNYIY----------DSTDMPDEEL-VSNKLILEDSPALTPPSPFRDSVASGSSLQS 1141

Human  1164 SPVSESVLCTPPNVSYASVILRDYKQSSSTL 1194
            ||||||||||||:|:||||:||||||.||||
 Frog  1142 SPVSESVLCTPPSVTYASVMLRDYKQVSSTL 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM1	NP_001264993.1	PBP1_mGluR_groupI	36..510	CDD:380597	410/473 (87%)
		NCD3G	521..571	CDD:462210	42/49 (86%)
		7tmC_mGluR1	591..840	CDD:320565	237/248 (96%)
		TM helix 1	591..616	CDD:320565	21/24 (88%)
		TM helix 2	628..649	CDD:320565	19/20 (95%)
		TM helix 3	658..682	CDD:320565	23/23 (100%)
		TM helix 4	706..726	CDD:320565	15/19 (79%)
		TM helix 5	749..775	CDD:320565	25/25 (100%)
		TM helix 6	783..806	CDD:320565	22/22 (100%)
		TM helix 7	809..834	CDD:320565	23/24 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..905		18/21 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1030		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1113..1173		34/59 (58%)
		GluR_Homer-bdg	1144..1194	CDD:431390	43/49 (88%)
grm1	XP_017949676.2	PBP1_mGluR_groupI	49..522	CDD:380597	410/473 (87%)
		NCD3G	533..583	CDD:462210	42/49 (86%)
		7tmC_mGluR1	603..852	CDD:320565	237/248 (96%)
		TM helix 1	603..628	CDD:320565	21/24 (88%)
		TM helix 2	640..661	CDD:320565	19/20 (95%)
		TM helix 3	670..694	CDD:320565	23/23 (100%)
		TM helix 4	718..738	CDD:320565	15/19 (79%)
		TM helix 5	761..787	CDD:320565	25/25 (100%)
		TM helix 6	795..818	CDD:320565	22/22 (100%)
		TM helix 7	821..846	CDD:320565	23/24 (96%)
		GluR_Homer-bdg	1122..1172	CDD:431390	43/49 (88%)