Protein Alignment GRM1 and grm1b

DIOPT Version :10

• Sequence 1: NP_001264993.1
• Gene: GRM1 / 2911
• HGNCID: 4593
• Length: 1194
• Species: Homo sapiens
• Sequence 2: NP_001289181.3
• Gene: grm1b / 100150246
• ZFINID: ZDB-GENE-090821-3
• Length: 1158
• Species: Danio rerio
• Alignment Length: 1200
• Identity: 870/1200 - (72%)
• Similarity: 990/1200 - (82%)
• Gaps: 50/1200 - (4%)

Human     1 MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPER 65
            |:.|.:.||....|..:.|..|..|..:...||  |||||||||:||||||||||||.||||.||
Zfish     3 MLILRMNFFIVFLLFCTRLHLSTERSAVSRAAS--RSVARMDGDIIIGALFSVHHQPSAEKVAER 65

Human    66 KCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISI 130
            ||||||||||||||||||:|||:||:||.||||||||.|||||||||||||||||||||||||||
Zfish    66 KCGEIREQYGIQRVEAMFYTLDRINSDPYLLPNITLGCEIRDSCWHSSVALEQSIEFIRDSLISI 130

Human   131 RDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK 195
            |||::|...|:....|..|..|||||||||||||||||||||||||||:||||||||||||||||
Zfish   131 RDEREGPKWCVEGNPSAQPPATKKPIAGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSIDLSDK 195

Human   196 TLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDK 260
            |||||||||||||||||||:||||||||||||||||||||||||||:||||||:|||||||||||
Zfish   196 TLYKYFLRVVPSDTLQARALLDIVKRYNWTYVSAVHTEGNYGESGMEAFKELASQEGLCIAHSDK 260

Human   261 IYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDE 325
            ||||||||.|||||||||||||||||||||||||||||||.|||||||.|||.||||||||||||
Zfish   261 IYSNAGEKHFDRLLRKLRERLPKARVVVCFCEGMTVRGLLMAMRRLGVAGEFLLIGSDGWADRDE 325

Human   326 VIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNF 390
            |:||||.||.||||:|||:.||.||:||||||||.||.|||||.|||||||||||.||..||.|:
Zfish   326 VVEGYEEEAVGGITVKLQTEEVTSFNDYFLKLRLATNNRNPWFAEFWQHRFQCRLVGHPQENTNY 390

Human   391 KRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI 455
            ::.|:|.||||:||||||||||||||||||||||.:||..|||||||||:.|.|||||||||||:
Zfish   391 RKNCSGYESLEDNYVQDSKMGFVINAIYAMAHGLHDMHEHLCPGHVGLCEEMDPIDGSKLLDFLL 455

Human   456 KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVV 520
            |:||.|||||:|||||.||:|||||||||||.|...:||::||:||||:|:||||.||||:|.:|
Zfish   456 KTSFAGVSGEDVWFDENGDSPGRYDIMNLQYVEPGVFDYINVGSWHEGILSIDDYMIQMNRSEMV 520

Human   521 RSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRY 585
            ||||||||.||:||||||||||||||||.||:|||||||||||||:|||||:.:|..|||:|:|:
Zfish   521 RSVCSEPCSKGEIKVIRKGEVSCCWICTPCKDNEYVQDEFTCKACELGWWPDEELQVCEPLPLRH 585

Human   586 LEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIA 650
            ||||:.|||.|:.|||||||||.||||:|:|||||||||||||||||||||||||||:|||||||
Zfish   586 LEWSHPESIAAVVFSCLGILVTSFVTLVFILYRDTPVVKSSSRELCYIILAGIFLGYICPFTLIA 650

Human   651 KPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILIS 715
            :|:..||||||||||||::||||||||||||||||||||||||||||||||||||||:||.||||
Zfish   651 RPSIASCYLQRLLVGLSASMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVVIAFILIS 715

Human   716 VQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN 780
            :||||.|||||:|||.||.|||||:||:|||||||:|:|||||||||||:|||||||||||||||
Zfish   716 MQLTLEVTLIILEPPEPIKSYPSIREVFLICNTSNMGMVAPLGYNGLLILSCTYYAFKTRNVPAN 780

Human   781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERN 845
            |||||||||||||||||||||||||||||||||||.|:|||||||||||||||||||||||||||
Zfish   781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTSFSVSLSVTVALGCMFTPKMYIIIAKPERN 845

Human   846 VRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMW 910
            |||||||||||||||||||:.||||:.||:|:|||..:||||||||||||||||....|||:|||
Zfish   846 VRSAFTTSDVVRMHVGDGKIACRSNSLLNMFKRKKNASGNANSNGKSVSWSEPGSRHPPKGEHMW 910

Human   911 HRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPS 975
            ||||||||..|...||||:|||||.:|...|  :.|||.||||||||.||::..|||::|..||
Zfish   911 HRLSVHVKKQEAGSNQTAIIKPLTNTYNNPG--MEFSDLSTKTLYNVAEEDEIDPIRYNPSNSP- 972

Human   976 MVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSN 1040
               |...|.:.....:.::||     .:..|..:|        ||....||. ::::..|..|..
Zfish   973 ---HLMAPVSKPMKEVGANLT-----FYTPEQHVP--------QQNSVLPQH-AMIEHFQDDVVK 1020

Human  1041 FSTAIPDFHAVLAGPGGPGNGL------RSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDD 1099
            |::.:.|...:::.| .|.:|:      :.|:|.|       :||  ::.:.:|..||.  ::.:
Zfish  1021 FNSNMADLDEIISLP-EPTDGIILALQPQVLHPHP-------ILP--MNVYQDEPSSPL--EEVE 1073

Human  1100 SERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSS 1164
            :|:|.||..|:|::.        ::.:|||.:|.  |:..:||.||.||||||||:.|||.|.:|
Zfish  1074 NEQFGLLHGYMYDNA--------QIHDEEELVQI--KMAMEDSMALMPPSPFRDSLGSGSPVRNS 1128

Human  1165 PVSESVLCTPPNVSYASVILRDYKQSSSTL 1194
            |||||||||||:|:||||||||||||||||
Zfish  1129 PVSESVLCTPPSVTYASVILRDYKQSSSTL 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRM1	NP_001264993.1	PBP1_mGluR_groupI	36..510	CDD:380597	398/473 (84%)
		NCD3G	521..571	CDD:462210	44/49 (90%)
		7tmC_mGluR1	591..840	CDD:320565	220/248 (89%)
		TM helix 1	591..616	CDD:320565	18/24 (75%)
		TM helix 2	628..649	CDD:320565	19/20 (95%)
		TM helix 3	658..682	CDD:320565	21/23 (91%)
		TM helix 4	706..726	CDD:320565	15/19 (79%)
		TM helix 5	749..775	CDD:320565	22/25 (88%)
		TM helix 6	783..806	CDD:320565	22/22 (100%)
		TM helix 7	809..834	CDD:320565	22/24 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..905		16/21 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1030		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1113..1173		29/59 (49%)
		GluR_Homer-bdg	1144..1194	CDD:431390	41/49 (84%)
grm1b	NP_001289181.3	None