DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PYCARD and pycard

DIOPT Version :9

Sequence 1:	NP_037390.2	Gene:	PYCARD / 29108	HGNCID:	16608	Length:	195	Species:	Homo sapiens
Sequence 2:	NP_571570.2	Gene:	pycard / 57923	ZFINID:	ZDB-GENE-000511-2	Length:	203	Species:	Danio rerio

Alignment Length:	199	Identity:	68/199 - (34%)
Similarity:	106/199 - (53%)	Gaps:	14/199 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     5 RDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSM-DALDLTDKLVSFYLETYGAEL 68
            ::.:.:|.|:|.|:.|:|||.||..   |....|:.:.|:..: |.:||.|.:|..:.......:
Zfish     6 KEHLQEAFEDLGADNLRKFKSKLGD---RRQEPRVTKSAIEKLKDEIDLADLMVGVFTSKDAVSV 67

Human    69 TANVLRDMGLQEMAGQLQAATHQG-SGAAPAGIQ--APPQSAAKPG---LHFIDQHRAALIARVT 127
            |..:||.:....:|..|...|.|. |..||:...  |..::.:|..   ::|||:|...||.||.
Zfish    68 TVEILRAIKCIAVADDLLRNTGQSESKGAPSDESKCASSKAVSKVAFSKVNFIDEHWKELIDRVN 132

Human   128 NVEWLLDAL-YGKVLTDEQYQAVRAEPTNPSKMRKLFS--FTPAWNWTCKDLLLQALRESQSYLV 189
            ||:.:||.| ..||:|:|.|..:|.:.|...|||:|.:  .|.|.| ..|::|..|||||..:|:
Zfish   133 NVDPILDILRQKKVITNEDYCTIRNKETPQKKMRELLTGPITCAGN-KGKEVLYDALRESNKFLM 196

Human   190 EDLE 193
            :|||
Zfish   197 DDLE 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PYCARD	NP_037390.2	Pyrin_ASC-like	5..86	CDD:260033	22/81 (27%)
PYCARD	NP_037390.2	CARD_ASC_NALP1	113..193	CDD:260039	36/82 (44%)
pycard	NP_571570.2	Pyrin_ASC-like	6..86	CDD:260033	23/82 (28%)
pycard	NP_571570.2	CARD_ASC_NALP1	118..200	CDD:260039	36/82 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I34402
eggNOG	1	0.900	-	-		E1_2CYBZ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I12360
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG41811
OrthoDB	1	1.010	-	-		D1494108at2759
OrthoFinder	1	1.000	-	-		FOG0002022
OrthoInspector	1	1.000	-	-		oto43000
orthoMCL	1	0.900	-	-		OOG6_114527
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3863
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	14	14.240