Protein Alignment DROSHA and drosha

DIOPT Version :10

• Sequence 1: NP_037367.3
• Gene: DROSHA / 29102
• HGNCID: 17904
• Length: 1374
• Species: Homo sapiens
• Sequence 2: NP_001103942.1
• Gene: drosha / 567505
• ZFINID: ZDB-GENE-070209-23
• Length: 1289
• Species: Danio rerio
• Alignment Length: 1377
• Identity: 1047/1377 - (76%)
• Similarity: 1123/1377 - (81%)
• Gaps: 107/1377 - (7%)

Human    10 MSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPP 74
            ||||.||||||||            .|...::.||..|  :|.|:|.:||...::.....:::||
Zfish     1 MSFHAGRGCPRGR------------LPAPGQIYHPAPP--RYHYDPSAAPGPVYNPQGGSSYMPP 51

Human    75 RPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQ 139
            .|||:.|..|.|..|...||.||||||.        |..||.||| |||.....:.|:    |.|
Zfish    52 HPDFMSFHFPPPSQASNTLPQCPIRPPV--------FTEPPPFPP-PPPHSSDGSTPM----PIQ 103

Human   140 GTFPFMM---PPPSMPHPPP--PPVMPQQVNY--QYPPGYSHHNFPPPSFNSFQNNPS-SFLPSA 196
            .::|:||   |||.:|..||  ||.||....|  .|||  .....||||||.....|| ||.|.
Zfish   104 NSYPYMMPNIPPPPLPPMPPSVPPTMPYPPTYPMSYPP--QPQLPPPPSFNPAYGQPSGSFKPE- 165

Human   197 NNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGR-GERHR---SLDRRERGRSPD 257
                    |..||... |..|..||||||:|:||||||.||:.. |.||.   ..::|:||.|.:
Zfish   166 --------RSRPPLHY-KTDSCSRSPERLRHHDDHRHRGHSYSEYGSRHNREFGGEKRDRGCSSE 221

Human   258 RRRQDS--RYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGL 320
            |||.||  |.:|||||||..|||||        |:|:||||:..|||.:|..|....|||
Zfish   222 RRRSDSPRRCKSDYDRGRVSSRHRS--------RDRYRHRDDPGSPSSDRHRKHARNRSG----- 273

Human   321 SVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYT 385
                                                |||:||.|.||:|:|.:|..||.::::..
Zfish   274 ------------------------------------SRERKRRRVEEDKERRTDGSSSSRERSVN 302

Human   386 SIKEKEPEETMPDKNEEE--EEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKF 448
            |.:.:|.||...|::||:  :|||.||.||||||:|||||:|||||||||||||||:|||||::|
Zfish   303 SSRSREAEEITIDRHEEDRGQEELHKPAWIRCTHAENYYSNDPMDQVGDSTVVGTSKLRDLYERF 367

Human   449 EEELGSRQEKAKAARPPWEPPKTKLDEDL-ESSSESECESD-EDSTCSSSSDSEVFDVIAEIKRK 511
            |||||.|||:||:.||.|||||||||:|. ||||||||||| ..|||||||||||||||||||||
Zfish   368 EEELGKRQERAKSIRPKWEPPKTKLDQDQDESSSESECESDGGGSTCSSSSDSEVFDVIAEIKRK 432

Human   512 KAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRI 576
            ||||||||||||||||||||||||||||||||||||||||||||:.:|.||||.||||:||||||
Zfish   433 KAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEQPVKQCRPMNNNAGKLFHYRI 497

Human   577 TVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFC 641
            |||||||||||||||||||||||:|||||.|:|.|||:||||:||||||||||||||||.|||:|
Zfish   498 TVSPPTNFLTDRPTVIEYDDHEYLFEGFSCFSHTPLTSIPLCRVIRFNIDYTIHFIEEMAPENYC 562

Human   642 VKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYL 706
            ||||||||.:||:||||||||||..| .|:||..|.||||||||||||||||||||||||:||||
Zfish   563 VKGLELFSSYLFKDILELYDWNLTDP-EENSPLGCQRFHFMPRFVRFLPDGGKEVLSMHQVLLYL 626

Human   707 LRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPI 771
            |..||.||||||||||||||||||||||||||||||||||.||||||||||||||||..||||||
Zfish   627 LHSSKPLVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGMKPSSVRIDQLDREQFNSSVITFPI 691

Human   772 IVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRR 836
            |||||||||||||||||||||||||||||||||||||||||.|||||.|||||||||||||||||
Zfish   692 IVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQIDKQKLMQREEALQKIRQKNTMRR 756

Human   837 EVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPS 901
            |||||||||||||||||||||||||||||||||||||||||||||||||.|::||||||||||||
Zfish   757 EVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYMFKERCLLQLAMTHPS 821

Human   902 HHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNE 966
            ||||||||||||||||||||||||||||||||||:|||||||||||||||||||||:||||||||
Zfish   822 HHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMYMRKKGINTLINIMSRLGQDDPSPSRINHNE 886

Human   967 RLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLC 1031
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Zfish   887 RLEFLGDAVVEFLTSVHLYHLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLC 951

Human  1032 RESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQ 1096
            ||||||||||||||||||||||||.|||||.||||||||..|:||||||||.||||:|||.||||
Zfish   952 RESDLRHAMANCFEALIGAVYLEGGLEEAKDLFGRLLFNTEDMREVWLNYPPHPLQVQEPLTDRQ 1016

Human  1097 LIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEY 1161
            |||:||||||||.||:||||:||||||||||||||||||||||||||||||||||||||||||||
Zfish  1017 LIESSPVLQKLTNFEDAIGVLFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEY 1081

Human  1162 LFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIA 1226
            |||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||
Zfish  1082 LFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEFAITNDKTKRPVALRTKTLADLLESFIA 1146

Human  1227 ALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVG 1291
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1147 ALYIDKDLEFVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVG 1211

Human  1292 PSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMR 1356
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1212 PSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMR 1276

Human  1357 WEREHQEREPDE 1368
            .|||.|||:.||
Zfish  1277 RERERQERDSDE 1288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DROSHA	NP_037367.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..95		31/84 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..406		110/291 (38%)
		SF-CC1	220..>278	CDD:273721	36/63 (57%)
		Necessary for interaction with DGCR8 and pri-miRNA processing activity. /evidence=ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718	390..1365		893/978 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..497		35/46 (76%)
		RIBOc	959..1079	CDD:238333	113/119 (95%)
		Rnc	1105..1333	CDD:440336	222/227 (98%)
drosha	NP_001103942.1	SF-CC1	213..>369	CDD:273721	93/204 (46%)
		RIBOc	877..989	CDD:238333	107/111 (96%)
		Rnc	1025..1253	CDD:440336	222/227 (98%)