back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DROSHA and drsh-1

DIOPT Version :10

Sequence 1:	NP_037367.3	Gene:	DROSHA / 29102	HGNCID:	17904	Length:	1374	Species:	Homo sapiens
Sequence 2:	NP_492599.1	Gene:	drsh-1 / 172830	WormBaseID:	WBGene00009163	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	1167	Identity:	364/1167 - (31%)
Similarity:	571/1167 - (48%)	Gaps:	166/1167 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   277 RHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELP-GEIIKN 340
            :|:...|.:.::..:.||::........|...:....|.....:..:|.|...|..|| |:..:.
Worm    14 KHKRARRKKYQKEYQERHKEEMMQQLGRRFQNQPSTSSAPPDTVEKIPLPTESTSALPFGDSPRL 78

Human   341 TDS-------WAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPD 398
            |:.       ..||  :|:..|....|                     .|...||.:|.|:.|..
Worm    79 TEKDYETNYMIDPP--VVSTHSAELIK---------------------SNRVVIKAEEAEKYMMI 120

Human   399 KNEEEEEELLK--------------------PVWIRCTHS-------------ENYYSSDPMDQV 430
            |.:....::|:                    |..|...||             |::.:||..|..
Worm   121 KAKSTTSKILQDFQTKILETVKTKRRLQADVPYIIHPCHSMKGRKTPKQKGGDESFTASDVSDDS 185

Human   431 GDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPP--WEPPKTKLDEDLESSSESECESDEDSTC 493
            .||                      |::|..:.|.  ..|...|..|          ..||..||
Worm   186 NDS----------------------QDEASTSEPTNRQAPEADKTGE----------VKDEKQTC 218

Human   494 S--------------SSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARR 544
            :              ...:.::..:...|.|||.||:.:|.::.:|:.|..|:||.|:|....:.
Worm   219 NRRNQQRKAKRLRNFEEKERQITLLKKGIDRKKTHPNGIHPDISFNEKGLGNEGPECRCPEPIKT 283

Human   545 TGIRHSIYPGEEAIKPCRPMTNNAGRLFHY--RITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMF 607
            .|::|..|.||:....|:  .:|...|.:|  |:|..|..|.|  ..|.:..:..|:.|||||:.
Worm   284 CGLKHGYYAGEDKAIDCK--KSNGENLHYYTLRVTPLPSENQL--YRTHMAINGEEFEFEGFSLI 344

Human   608 AHAPL----TNIPLCKVIRFNIDYTIHFIEEMMP-ENFCVKGLELFSLFLFRDILELYDWNLKGP 667
            .||||    |..|:||   :::||....:||.|| |.|..:..::...::|.:|.|:.|:.|:..
Worm   345 THAPLPDCMTRAPICK---YSMDYEFQLVEEFMPDECFDPEDCDMLFEYIFHEIFEMLDFELRPK 406

Human   668 LFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLL-RCSKALVPEEEIANMLQWEELEWQ 731
            ........||..|.|||||: ..|...::.|...:|.|.. :.|..::..|::..:...:..::.
Worm   407 HIPSDVESCPMIHIMPRFVQ-TKDDLVQLWSSKTVLAYFTSKGSSEIMSPEDVNRLCDAQIDQFT 470

Human   732 KYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKS 796
            :...:.|..||.|...|||::|.|..:|::...:|    .:||..||....:....|:...|.|:
Worm   471 RNTSKHKQSIVLNTKFKPSAIRADWFERDEEKKEV----YVVHNAIRAQTYTAISLPRIAFLEKT 531

Human   797 YVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAM 861
            ..|:.. ...|..|...|.:|   .:..|:.::::|...|.:.:.....||.:||::.||..|.:
Worm   532 LNKMIQ-EKQSSGVYNKDFEK---TKNELEHLKRENRSARNLKLREPVAGFIETGLKPDVAAHVV 592

Human   862 MLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPK 926
            |..:..|||||:..|...:::|.|.|.||.:::||:.|.|...::|...||.:|.::|||.|: |
Worm   593 MTILACHHIRYNFSLDVFEEVIEYKFNDRRVIELALMHSSFKSHYGTPIDHVKNMITNCGYRR-K 656

Human   927 YG--DRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFP 989
            ||  |::   ...|..||.:|.|||......:|    |.||||||:|||||||.:.|.|||::..
Worm   657 YGAEDKR---EKKRVAGIMSLFNIMKGTSGGEP----ILHNERLEYLGDAVVELIVSHHLYFMLT 714

Human   990 SLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLE 1054
            ...||||||||||:|||::||.|||...:|..:.|:||.||...::.:||:||.|||::.|:||:
Worm   715 HHFEGGLATYRTALVQNRNLATLAKNCRIDEMLQYSHGADLINVAEFKHALANAFEAVMAAIYLD 779

Human  1055 GSLEEAKQLFGRLLF-NDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIF 1118
            |.|.....:|.:.:: :.|.|:|.|.:...|.|:.::|..||.|...:|.|......||.:|:.|
Worm   780 GGLAPCDVIFSKAMYGHQPVLKEKWDHINEHELKREDPQGDRDLSFITPTLSTFHALEERLGIQF 844

Human  1119 THVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVN 1183
            .::||||:|||.|.:..|.||.|||||:|:||||::||:.:::|:..||.|||||::|||:|||:
Worm   845 NNIRLLAKAFTRRNIPNNDLTKGHNQRLEWLGDSVLQLIVSDFLYRRFPYHHEGHMSLLRTSLVS 909

Human  1184 NRTQAKVAEELGMQEYAITNDKTKRPV---ALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCF 1245
            |:|||.|.::||..|:.|     |.|.   .|:.|..|||:|:||.|||:|:.:|:...|:.:.|
Worm   910 NQTQAVVCDDLGFTEFVI-----KAPYKTPELKLKDKADLVEAFIGALYVDRGIEHCRAFIRIVF 969

Human  1246 FPRLKEFILNQDWNDPKSQLQQCCLTLR-TEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERI 1309
            .||||.||.::.|||.||.|||.||.:| ....|||:|.|:.|...||::.|.:.:|||:||:|:
Worm   970 CPRLKHFIESEKWNDAKSHLQQWCLAMRDPSSSEPDMPEYRVLGIEGPTNNRIFKIAVYYKGKRL 1034

Human  1310 GCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETED 1371
            ......::.:||:..|..||.  |...|:..|        .:.|...|.:..:.|...:|.|
Worm  1035 ASAAESNVHKAELRVAELALA--NLESMSFSK--------MKAKNNSWFQNMRRRLEQDTSD 1086

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.