Protein Alignment SLC25A4 and Shawn

DIOPT Version :10

• Sequence 1: NP_001142.2
• Gene: SLC25A4 / 291
• HGNCID: 10990
• Length: 298
• Species: Homo sapiens
• Sequence 2: NP_001027071.1
• Gene: Shawn / 3772641
• FlyBaseID: FBgn0031039
• Length: 387
• Species: Drosophila melanogaster
• Alignment Length: 280
• Identity: 57/280 - (20%)
• Similarity: 111/280 - (39%)
• Gaps: 56/280 - (20%)

Human     9 LKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHA------------------------SKQISAEK 49
            |:...:....|.|:...:.|::.:|..||.|..                        :...:|.|
  Fly    40 LQQVASACTGAMVTACFMTPLDVIKTRLQAQQQALLSNKCFLYCNGLMDHICPCGPDTPNPAAAK 104

Human    50 ---QYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWR 111
               ::.|.||..::|.:.:|..|.|.|....:|...|:..:.|...:::|..|   .|.|.::.|
  Fly   105 PAPRFSGTIDAFIKISRTEGIGSLWSGLSPTLISALPSTIIYFVAYEQFKARF---TDIHYKYTR 166

Human   112 Y-------------FAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHG-LGDCII 162
            .             |...|.:|.:....::..|.|::..||::       .:||..|. :...|.
  Fly   167 RPDTIAHDIPHPIPFLVPLLAGVSGRILAVTCVSPVELIRTKM-------QSQRMTHAEMFGTIR 224

Human   163 KIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGM--LPDPKNVHIFVSWMIAQSVTAVAG 225
            ::.:|.|:.||::|...::...:.:...|:..|:..|..  :.:|.....|.:..|:.||.|.
  Fly   225 QVVQSQGVLGLWRGLPPTILRDVPFSGIYWTCYEYLKSSFGVVEPTFSFSFAAGAISGSVAAT-- 287

Human   226 LVSYPFDTVRRRMMMQSGRK 245
             ::.|||.|:....::.|.|
  Fly   288 -ITTPFDVVKTHEQIEFGEK 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A4	NP_001142.2	Solcar 1	6..98		22/115 (19%)
		PTZ00169	7..298	CDD:240302	57/280 (20%)
		Solcar 2	111..201		20/103 (19%)
		Solcar 3	212..297		10/34 (29%)
		Important for transport activity. /evidence=ECO:0000269|PubMed:27693233	235..240		0/4 (0%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		0/4 (0%)
Shawn	NP_001027071.1	Mito_carr	39..159	CDD:395101	23/121 (19%)
		Mito_carr	178..265	CDD:395101	19/93 (20%)
		Mito_carr	268..371	CDD:395101	12/42 (29%)