DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC25A4 and Ant2

DIOPT Version :9

Sequence 1:NP_001142.2 Gene:SLC25A4 / 291 HGNCID:10990 Length:298 Species:Homo sapiens
Sequence 2:NP_001259432.1 Gene:Ant2 / 32008 FlyBaseID:FBgn0025111 Length:307 Species:Drosophila melanogaster


Alignment Length:307 Identity:220/307 - (71%)
Similarity:252/307 - (82%) Gaps:11/307 - (3%)


- Green bases have known domain annotations that are detailed below.


Human     1 MGDHAW----------SFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGII 55
            |||...          |||.||:.|||:||::||||||||||||:||||..||||:|:::||||:
  Fly     1 MGDEGGGGGHGKGDLKSFLMDFMMGGVSAAIAKTAVAPIERVKLILQVQEVSKQIAADQRYKGIV 65

Human    56 DCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASG 120
            ||.:||||||||.|||||||||||||||||||||||||.||.:||||||:||||||:||||||||
  Fly    66 DCFIRIPKEQGFSSFWRGNLANVIRYFPTQALNFAFKDVYKSVFLGGVDKHKQFWRHFAGNLASG 130

Human   121 GAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGII 185
            |||||||||||||||||||||||||||| ..|||:||.||::|:.||||..|||:||.||||||:
  Fly   131 GAAGATSLCFVYPLDFARTRLAADVGKG-GNREFNGLIDCLMKVIKSDGPIGLYRGFIVSVQGIV 194

Human   186 IYRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIM 250
            ||||||||.|||.:..||:||:...:|||.|||.||.|||:.||||||||||||||||.|.::::
  Fly   195 IYRAAYFGFYDTCRDFLPNPKSTPFYVSWAIAQVVTTVAGIASYPFDTVRRRMMMQSGLKKSEMV 259

Human   251 YTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKY 297
            |..|..||..|||.||..||||||.||::||.|||.||.||||:|||
  Fly   260 YKNTAHCWLVIAKQEGIGAFFKGALSNIIRGTGGALVLALYDEMKKY 306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC25A4NP_001142.2 Solcar 1 6..98 72/101 (71%)
PTZ00169 7..298 CDD:240302 217/291 (75%)
Solcar 2 111..201 71/89 (80%)
Solcar 3 212..297 57/84 (68%)
Important for transport activity. /evidence=ECO:0000269|PubMed:27693233 235..240 4/4 (100%)
Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722 235..240 4/4 (100%)
Ant2NP_001259432.1 PTZ00169 15..305 CDD:240302 214/290 (74%)
Mito_carr 17..111 CDD:278578 73/93 (78%)
Mito_carr 119..215 CDD:278578 75/96 (78%)
Mito_carr 218..307 CDD:278578 59/89 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 135 1.000 Domainoid score I4973
eggNOG 1 0.900 - - E1_KOG0749
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S337
OMA 1 1.010 - - QHG54049
OrthoDB 1 1.010 - - D440386at33208
OrthoFinder 1 1.000 - - FOG0000386
OrthoInspector 1 1.000 - - mtm8481
orthoMCL 1 0.900 - - OOG6_100505
Panther 1 1.100 - - O PTHR45635
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R28
SonicParanoid 1 1.000 - - X286
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.810

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