Protein Alignment SETD2 and SET2

DIOPT Version :10

• Sequence 1: NP_054878.5
• Gene: SETD2 / 29072
• HGNCID: 18420
• Length: 2564
• Species: Homo sapiens
• Sequence 2: NP_012367.2
• Gene: SET2 / 853271
• SGDID: S000003704
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 816
• Identity: 209/816 - (25%)
• Similarity: 352/816 - (43%)
• Gaps: 226/816 - (27%)

Human  1413 SDSESDGELQDRKKVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIE 1477
            |.::|....:|.|::.....:|..          |..:.|  ::|...:|...:      |:.::
Yeast     2 SKNQSVSASEDEKEILNNNAEGHK----------PQRLFD--QEPDLTEEALTK------FENLD 48

Human  1478 ENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQG-EIACGE--DCLNRLLMIEC----SSRCPN 1535
            :.:|..:|.....:.|.  |:|:|    .:|.:.| ..||.|  ||:|||.:|||    .|.|
Yeast    49 DCIYANKRIGTFKNNDF--MECDC----YEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSC-- 105

Human  1536 GDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNK 1600
            |:.|.|:|||:||:|.:.:..|:.||:|:||.:|:.:|.|:.||.|||::..||:.|:.:|.:..
Yeast   106 GNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRH 170

Human  1601 NIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFD 1665
            ..|:|||.|:|.|.||||.||:.:||.||||.||....||.|..:||:|.|..:.:..|.|:|||
Yeast   171 FKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFD 235

Human  1666 YQFQRYGKEAQKCFCGSANCRGYLGGENR------------------VSIRAAGGKMKK------ 1706
            |...|||.:||||:|...||.|:|||:.:                  ||:.....|:||
Yeast   236 YNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPI 300

Human  1707 ------------ERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQ 1759
                        .:|.:...:|..::........|...|:::: |:|:.|:.|::......:.|:
Yeast   301 IKNENENINIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIA-SKLLKRLFTIDDDSLRHQAIK 364

Human  1760 NTHSQSCLKSFLERHGLSLLWIWMAELGDGR-----ESNQKLQEEIIKTLEHLPIPTKNMLEES- 1818
             .|..:|....|:      |:|......||:     |.:.|..:.|:..|..||..|:|.:|.|
Yeast   365 -LHGYTCFSKMLK------LFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQ 422

Human  1819 -----KVLP------------IIQRWSQTKT----------------------AVPP---LSEGD 1841
                 |.||            ::::||:.:|                      .:||   :...:
Yeast   423 IDNVVKTLPAKFPFLKPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHEN 487

Human  1842 G----YSSENTSRAHTPLNTPDPSTKL-STEADTD-----------TPKKLMFRRLKIISENSMD 1890
            |    |::|..::.|.|   |..|:|: |:.::|.           ||..|..::.|:..|
Yeast   488 GRPLYYNAEQKTKLHYP---PSGSSKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDE---- 545

Human  1891 SAISDATSELEGKDGKEDLDQLENVPVE--EEEELQSQQLLPQQLPECKVDSETNIEASKLPTSE 1953
                    |.|.|  |:...:.|.:.:|  ::|||:|   |.|:|   |:::|..
Yeast   546 --------EYERK--KQKRLEYERIALERAKQEELES---LKQKL---KLENERK---------- 584

Human  1954 PEADAEIEPKESNGTKLEEPINEETPSQD--EEEGVSDVESERSQEQPDKTVDISDLATKLLDSW 2016
                          :.||:.|.|....::  :||....||::.::....|||..|.   :|..:|
Yeast   585 --------------SVLEDIIAEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQSQ---RLEHNW 632

Human  2017 KDL------KEVYRIPKKSQTEKENTTTERGRDAVGF-------RDQTPAPKTPNRSRERDPDKQ 2068
            ...      ..:.:.|:..|.:.|| ..:..:|.|..       :|.:.||.......:|...|:
Yeast   633 NKFFASFVPNLIKKNPQSKQFDHEN-IKQCAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKE 696

Human  2069 TQN--------KEKRKRRSSLS---------PPSSA 2087
            ..|        |:|:|:..:||         |||::
Yeast   697 FINSYMDKIILKKKQKKALALSSASTRMSSPPPSTS 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SETD2	NP_054878.5	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..211
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..561
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..626
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..995
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1036..1101
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1133..1233
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1264..1352
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1393..1443		5/29 (17%)
		Interaction with TUBA1A. /evidence=ECO:0000269|PubMed:27518565	1418..1714		110/338 (33%)
		AWS	1495..1549	CDD:197795	25/60 (42%)
		SET_SETD2	1549..1690	CDD:380949	64/140 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1831..1872		13/81 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1921..2142		43/199 (22%)
		Low charge region. /evidence=ECO:0000269|PubMed:16118227	2137..2366
		WW	2391..2420	CDD:459800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2439..2465
		Interaction with POLR2A. /evidence=ECO:0000269|PubMed:16314571	2457..2564
		SRI	2467..2555	CDD:462404
SET2	NP_012367.2	AWS	64..119	CDD:197795	26/62 (42%)
		SET_SETD2	119..260	CDD:380949	64/140 (46%)
		WW_1	479..505	CDD:375933	6/28 (21%)
		TolA	545..>626	CDD:442298	27/124 (22%)
		SRI	627..703	CDD:462404	14/76 (18%)