|
Human 23 PEEEEN----EAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKT 83
||..|: ..|:||..|....||...:.|.::..|.||.|||||||||||||||||.:.|||.
Zfish 7 PELREDVKDCSIKVENFPKQVIFKGLAPRVVLTNHLLMKGNKTKVNLEEQGRQKVSFSLTQTKKP 71
Human 84 LQNRFLTALGNEK----QSDTPNPPAVPLQVD------------STPKMKMEIGDTLSTAEESSP 132
.||.||.....|| .|.|.....||:.|. :|| .:|:|.:....|..
Zfish 72 RQNVFLPPPSPEKSASEHSSTSQAGPVPVSVQAGQTYETKNVDTNTP----AVGETQTAPTVSFS 132
Human 133 PKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPA 197
.:||..|||:||||.:|..| |:.:.:||.
Zfish 133 LRSRHVLGKMHFKKQILSST-----------------------VVGDKSTVS------------- 161
Human 198 QATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNS 262
::.|.::||| :|.|....|.| :....||:...|...:..|
Zfish 162 -----TASAEISEPV----------------VPSDKITSSAK----VETENSLQQSHKNSVVDGS 201
Human 263 LEEHVTQILNEQADISS---KKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESD 324
.|.|::..|.|..|:| ..:.|||||:: .|||.|| :...|:|....|:....|.|:|
Zfish 202 -SEKVSKEENPQEKIASCLKGPDSSHIGKED--TDSSIIS---EHEESRKSKQCSDSKLAGLETD 260
Human 325 EDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDD--KYFSYSKLERDT 387
..|.||||||:|:|.:.....|...:..|.|:..|:| ..:|:|||.| |...:||.:||:
Zfish 261 GQSTRTSSSQKSNDRRNKTKSESHSNEVKRSSNSKTE----LDKSRTDRKDEEKGIRHSKSDRDS 321
Human 388 RYVSSR-CRSERERRRSRSHSRS-ERGSRTNLSYSRSE-----------RSHYYDSDRRYHRSSP 439
|::||| .||:|:|||::|.||| .|||||: |||||| ||||::|:||:|||||
Zfish 322 RHMSSRSSRSDRDRRRTKSRSRSRSRGSRTS-SYSRSERSRSERQSRTDRSHYHESERRFHRSSP 385
Human 440 YRERTRYSRPYTDNRARESSDSEEEYKKTYSR-----RTSSHSSSYRDLRTSSYSKSDRDCK-TE 498
:||| |.||..||.|:|:|||||:::::|.:| |:|::|||.:|.::|::|:|.||.| |:
Zfish 386 HRER-RSSRSRTDGRSRDSSDSEDDHRRTRTRGSDSSRSSTYSSSQKDSKSSTHSRSHRDSKPTD 449
Human 499 TS-YLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKP 562
.| ..|.::|.:: ||.|...:.:||.:|: |..|::|.|
Zfish 450 CSRSSESDKRAQH-SKSESNRRSSSEIDAV--------------------HKKSSARTK------ 487
Human 563 IPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSP-APSNRLNDSPT 626
:..:||..||...|......|:.| :|......|.|. :|:..||. :|.:..:.|.
Zfish 488 LEVNDKISNSNLTTSSRTSEKKIH----KTSSDSDEEHRR-----KRQSQGSDRSPRSGTSSSR- 542
Human 627 LKKLDELPIFKSEFITHDSHD--SIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTS 689
|::.:.|:|.: :..|..|..: ||.| |:.....|.|.
Zfish 543 ----------KNDLVDHNSFNIGTGTERQSTDR-------------LNTN----AKDSQLVFVTV 580
Human 690 KTDAVLMTSDDSVTGSELSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVS 754
.:.......||..|..: |.|..|.:.....| .:.|..:||:|. .
Zfish 581 TSQKESSNIDDQCTPPK----------SKNSSQQMHEATHK--VNLCETNKKAEH---------Q 624
Human 755 PHQDKLMSMPVMT-VDYSKTVVKEPVDTRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMK 818
|....|.|:...| |..||... |.:...:|....| |...:|: |..||. ||
Zfish 625 PSNQDLSSLEKCTNVPESKKTT-ERLTESISITSGK-------LEVRSPT------EVDEPG-MK 674
Human 819 ISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSL 883
:: |.::|:.: ::|.|.|..|......: .:||...:.|:
Zfish 675 VT------VPIQSEVL--------------------TVGQTESICVGPAPSEH-TMGSLTDSLSV 712
Human 884 QSLPP------GIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGS-DLPDSG- 940
:.||| ..|.|..:|: ..:.::||...|...:|.|| ..:|| :.|::|
Zfish 713 KELPPEGSLILNTKSDESSLI-ISQISTPVTLTVQPCEKDSE----------QNIGSPEQPNTGI 766
Human 941 --KGFASRENRRNNGLSGKCLQEAQEEGNSILPE---------------------RRGRPEISLD 982
|..:::::|.: :.|:...|.|.....:.|: ::..||:..:
Zfish 767 SKKDASAKKSRWD--IVGQVTSEYQSPAKLVNPDVKKVMLAQKIEFSDTTPDNCSQKLDPEVPSE 829
Human 983 ERGEGGHVHTSD----DSEVVFSSCDLNL-TMEDSDGVTYALKCDSSGHA--------------- 1027
:..| ||..| :|....||...|. |....|.:...::...|..|
Zfish 830 KSVE---VHARDTTAAESHQEISSFTSNFGTKGTHDELQKTVEIPQSTSALVVSDFQPSKEKVNV 891
Human 1028 ----PEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPME-----ET 1083
|||......::.|...|.:.||:..|:||||..:...||.||||||||||:.:| |.
Zfish 892 DKTKPEIQDPDSLNHDGKCHSDDSESEESDSDSDDGRVSLKRLHSVVVVPKNSTIALETNDKAEP 956
Human 1084 SPCSSRSS---QSYRH--------YSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGT 1137
:|.||..| |:..| |..:.:....||...|| :..|..||...:. ||
Zfish 957 APASSLFSGNQQTDTHESINKEFPYGFNNQSTLKESSAALY----KGSAQAACQSPNV----KG- 1012
Human 1138 EKNPEISFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGH--PNSEETVKAKIPSRQQE 1200
:|: || ||:.||||||.:|.| .| .|.....:..|..:..:
Zfish 1013 -----VSY-QS---------------QSNMVDSTSHLEVMS---AHVDKNWSAQERPNISGQINQ 1053
Human 1201 ELPIYSSDFE---DVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDF 1262
| |..:|| :.|.....| :..||||..|: .|..|.....:|.|||
Zfish 1054 E---YVQNFEKTCEKPETDHHQ--YHGRPDSWNGR--------------KGDFSVGRGDSLVWDF 1099
Human 1263 SQ-EKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDP---RSGRPPGTGV---VY 1320
:| |:||:|:|||||||.. .|.........|.|. .| ::.|...|.| .:
Zfish 1100 NQSEQPSSTFQQPDSSYST------PQPLFDSVHREDPWA-----QPAISKTSRTVNTHVPFQYH 1153
Human 1321 DRTQGQVPDSLTDDREEEENWDQQDGSHFS-DQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVN 1384
|......|||||:|.: |.::|.... .|:......|......|||||||||....|
Zfish 1154 DLVHQIHPDSLTNDHD-----DDREGRILGIKQASLLSAGLPGPSPFVQAPEISSNCSFTT---- 1209
Human 1385 EKKDFSKNLEKNDIK---DRGPLKKRRQEIESDSESDGE---------------LQDRKKVRVEV 1431
|.::.|:....::.| .|||.||||||.||:|:::.| |:|.|:...::
Zfish 1210 ESQNISEAPRDDNQKPHRGRGPPKKRRQEFESESDNEAEAGLSKRECFDESSRPLKDAKESFHQI 1274
Human 1432 EQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKR 1496
::.:. |...:.:|.||..|::.|||.|||.||||||||:||||||||||||||||
Zfish 1275 QEVQR----------PLLSLKEFSDPFVWRDKAKQKKMPPYFDLIEENLYLTERKKNKSHRDIKR 1329
Human 1497 MQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKG 1561
|||||..|||:|||:|.:|||||||||||||||||||.||.||||||||.|||||.||||||.||
Zfish 1330 MQCECAILSKEERARGILACGEDCLNRLLMIECSSRCLNGAYCSNRRFQMKQHADYEVILTESKG 1394
Human 1562 WGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRF 1626
|||||||||..||||||||||||||:||||||||||||||||||||||||:||||||.|||||||
Zfish 1395 WGLRAAKDLQPNTFVLEYCGEVLDHREFKARVKEYARNKNIHYYFMALKNNEIIDATLKGNCSRF 1459
Human 1627 MNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGG 1691
|||||||||||||||||||||:||||||.|.:|:|||||||||||||||||||||:.:|||.:||
Zfish 1460 MNHSCEPNCETQKWTVNGQLRIGFFTTKAVTAGTELTFDYQFQRYGKEAQKCFCGAPSCRGLIGG 1524
Human 1692 ENRVSIRAAGGKMKKERSRKKD------SVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQ 1750
|.|||:||||||.::||||||| ::|.|||||.||||||..:.:|:||.|||||:||:||
Zfish 1525 ETRVSVRAAGGKKQRERSRKKDTDSALTTLDEELEALQENGEGLCGEKEVISLCRLMVRVETMEQ 1589
Human 1751 KLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRE---SNQKLQEEIIKTLEHLPIPTK 1812
:||||:|||||.:..|||.||:.||||||||:|.||.:.:. :|.|||.||:|.|..|||.||
Zfish 1590 RLTCLKLIQNTQNPLCLKQFLDHHGLSLLWIFMVELSEAKTNSVNNIKLQLEIMKALSVLPISTK 1654
Human 1813 NMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPD-PSTKLSTEADTDTPKKL 1876
||||||:||..||||:|:::...| :|.||||||:||||.||||||| |..||:||.|.||||:.
Zfish 1655 NMLEESRVLQFIQRWAQSRSLSQP-AEQDGYSSESTSRAQTPLNTPDGPPAKLATELDGDTPKRA 1718
Human 1877 MFRRLKIISENSMDSAISDATSELEGKDGK-EDLDQLENVP-----------------------V 1917
::||||||||||:|||:|||:...:||:.: |:.:::|:.| .
Zfish 1719 VYRRLKIISENSLDSALSDASKASDGKEEEDEEEEEMEDEPSKLESTTERKIKVESTEAPPVSQA 1783
Human 1918 EEEEELQSQ--------QLLPQ-----------QLPECKV------------------------- 1938
|.|.||:.: :|:|: |.||.|:
Zfish 1784 ELEVELKQEAPETVEIPRLMPEAVGSEGETLETQEPEEKLLCTPEGQLKDEKTVEETKSDEPSEN 1848
Human 1939 ----------------------------DSETNI-------EASKLPTSEPEAD---AEI----- 1960
|:||.: .:|:..|||.:|. |||
Zfish 1849 QTESAAVKEDPLVTDTTSAADISNDVVADAETPVTETQVENASSEQSTSEEDASCSTAEITSAQP 1913
Human 1961 -------------------EPKE----------------SNGTKLEE------------------ 1972
.||| |||....|
Zfish 1914 AEVIIEGISSDSAAIVIKSTPKESPSVSVKTPPTGSDVVSNGNAPSEAVFAPSEAVAAPLEAAVA 1978
Human 1973 ----------------------------------------------------------------- 1972
Zfish 1979 PSEAVASFPEAVASLPETVAAPAEAVDEPAEAVADPAEAVADPAEAVADPAEAVAEPAEAVAAPA 2043
Human 1973 -------------------------------PINEE-----TPSQDEEEGVSDVESERSQEQPDK 2001
|:..| ||||||||||||||||||||...:
Zfish 2044 EAVAAPPEAVAAPPEAVAAPVSADVSALAIVPVPAEGAAVGTPSQDEEEGVSDVESERSQEPQIR 2108
Human 2002 TVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPD 2066
..||||:|.:|||||||||||||||||||.|||:....|.|::: .||...:.:|.|||:.|
Zfish 2109 ASDISDMAARLLDSWKDLKEVYRIPKKSQVEKESNDRSRDRESL----MTPRTSSSSRERERERD 2169
Human 2067 KQ-----------------------------TQNKEKRKRRSSLSP-PSSAYERGTKRPDDRYD- 2100
|: .::.::::||.|.|| |..|||| ::|.||||:
Zfish 2170 KERDRDRDRDWEREREWDRDRERDRDGERPTLRSADRKRRRGSTSPLPPPAYER-SRRNDDRYEQ 2233
Human 2101 TPTSKKKVRIKD-RNKLSTEERRKLFEQEVAQREAQK---------------------------- 2136
:.:||||:..|: |.||||||||||||||||||||||
Zfish 2234 SSSSKKKLHTKEARTKLSTEERRKLFEQEVAQREAQKQQQQQLQQQQQQQQQQQQQQQQQQQQQQ 2298
Human 2137 ---------------QQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGK 2186
||||:|.|.. :||.|.| :|: |..||||||:|.||||:||||||
Zfish 2299 QQQQQQQQQQQQQQQQQQQLQTLAF-NPLAYTS----SPN--FMNYPPGYPIQTYVDPTNPNAGK 2356
Human 2187 VLLPTPSMDPVC-SPAPYDHAQPL-----VGHSTEPLSAPPPVPVVPHVAAPVEVSS---SQYVA 2242
||||||.::|:| :||.....||. :...:...:...|...:.|:.||:|:|| :|:|
Zfish 2357 VLLPTPPVEPICVTPAAGTFEQPPALDLGIASPSSTTTQAGPASSLAHIPAPLELSSGTQTQFV- 2420
Human 2243 QSDGVVHQDSSVAVLPVPAPG-----PVQGQNYSVWDSN-QQSVSVQ----QQYS-PAQSQATIY 2296
...|..||.|||||.|||.. |.|....::||.| ||:|:|| |||| .:|.||.||
Zfish 2421 -QPAVPAQDPSVAVLSVPAQAASPQIPSQQGYTTLWDPNTQQAVTVQTQPTQQYSTTSQPQAAIY 2484
Human 2297 YQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQP 2361
||||.|.|:|.:.:.|.||.||::|:|.:|:..|:..||::| || ..|||||. .
Zfish 2485 YQGQPCQTIYSIPAGYPQTNPPVIQAYTEPAANYLHSQQVYT---QG------GTVTTIVT---S 2537
Human 2362 QPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPG 2426
||:| .||:|.||::|||||||||||||:|||:||.||||||:|||||:||||||||||:|:...
Zfish 2538 QPVQ-QEMIVPNNIIDLPPPSPPKPKTIILPPSWKVARDPEGRIYYYHIITRQTQWDPPSWDGTT 2601
Human 2427 DDASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRK 2491
::||:|||||||||||||||||.|.| .||||||||||||||||||||||||||||||||||||
Zfish 2602 EEASVEHEAEMDLGTPTYDENPSKFS--TKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRK 2664
Human 2492 PDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYK 2556
||||:|||:.|||||||||||||||||||||.|||||||||||||||||||||||||||||:||:
Zfish 2665 PDCKLGRISNTEDFKHLARKLTHGVMNKELKSCKNPEDLECNENVKHKTKEYIKKYMQKFGSVYR 2729
Human 2557 PKEDTELE 2564
|||||||:
Zfish 2730 PKEDTELD 2737
| 
