DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SETD2 and pps

DIOPT Version :9

Sequence 1:XP_011531934.1 Gene:SETD2 / 29072 HGNCID:18420 Length:2572 Species:Homo sapiens
Sequence 2:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster


Alignment Length:2438 Identity:425/2438 - (17%)
Similarity:702/2438 - (28%) Gaps:948/2438 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   255 PESLEADTK-------------QDTISNSLEE------HVTQILNEQADISSKKEDSHI------ 294
            |.:.|||:.             :..|.|.:||      .|.:|.:....:..::||..:      
  Fly    14 PAAAEADSNLVVVYSKSGISFDERAIGNIMEEKSISTISVVRITSPTPSMVDQEEDERLEELANF 78

Human   295 ---GKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSS---QRSHDLKFSASI 353
               ..|.|: ||...|.|.....|:......|....|.:::.||..|.:.   .|....:...:|
  Fly    79 METATDSEL-DSDNGSQSGGDNASEMDEHDEENHNTGDDNNSDSTETEADAPRTRKRVGRKPKAI 142

Human   354 EKERDFKKSSAP-----------------------LKSEDLGKPSR-SKTD-------RDDKYFS 387
            :|.:..|....|                       ||...:....| ::||       .|..|..
  Fly   143 KKRKRRKPKERPQIVGLRVEQFYADNTADMVVKNALKLAGVSVYKRTAETDALMEVIRNDHNYTP 207

Human   388 YSKLERDTRYVSSRCRSERERRRSRSHSR---------------SERGSRTNLSYSRSE------ 431
            ::..|:    :.:..|.|:.....::.||               .:|.....||..:.:      
  Fly   208 FTSPEQ----LKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLSPVQVKVQRLPV 268

Human   432 RSHYYDSDRRYH-----------------------------RSSPYRERTRYSRP-----YTDNR 462
            :.|......:..                             |..|.|...:...|     ..|:.
  Fly   269 KPHQVQQAAQLQPKVQLIRKPIHSPLPRQKPEIIANNSVNARLRPTRAPVKVIAPPVQEYIEDDD 333

Human   463 ARESSDS--EEEYKKTY-SRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLER 524
            ..:||||  ||...|.| |...|..|..:::      |.:|||...:.......||.....|..|
  Fly   334 DAQSSDSAEEENADKAYDSEEMSEESDEFQE------SDNDRDSDMDFDMRHSNRRNPNKRKRVR 392

Human   525 ESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEE 589
            :..|.:.::.:|....||         :..:|.....:.|..|....|:..:.            
  Fly   393 KVVRQTPSKPMKPLPPPP---------TTPQHFPELKKRKEVLEPKAPQIGQI------------ 436

Human   590 IKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNR-LNDSPTLKKLDELPIFKSEFITHDS 653
                    :|.|.:|..        |.....|...||.. |...||.:   .||:.:....|..:
  Fly   437 --------IQMPATKSV--------PAVFALGRGLPSTSFLKIRPTHQ---SLPVKRPPLPTTPA 482

Human   654 HDSIKEL---------DSLSKVK----NDQLRSFCPIELNINGSPGAESDLATFCTS---KTDAV 702
            :.:::.:         :|..:||    |..:.|...:..|:|...|.:::.||..:.   :..||
  Fly   483 NSNVRRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLRHRAV 547

Human   703 LMTSDD-SVTGSELSPLV----KACMLSSNGFQNISRCKEKDLDDTCMLHK----------KSES 752
            :..|.. |....::||:|    ......|.||..|.       .||...||          :|.|
  Fly   548 MSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIG-------VDTAQSHKLPAQIVIETHQSSS 605

Human   753 PF-----RETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCTLNDSNPSL 812
            ..     ::.:.:.|..||:|:         ..|:|::||       ...|.||        |.|
  Fly   606 ELAAENDKQLDLINSIVQDELL---------KSTLVEQPV-------VNADEDI--------PKL 646

Human   813 ---CNSEAENIEPSVMKISSNSFMNVHLE--SKPVICDSRNLTD--------------------- 851
               ..|.|.:::|..:.:.:|.|....::  ......|..|:.|                     
  Fly   647 VKMLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEE 711

Human   852 HSKFACEEYKQSIGSTSSASVNHFDDL---YQPIGSSGI---------------ASSLQSLPPGI 898
            ..:|..|..||.:.||...:::....:   .:|:....:               |.|:.|||...
  Fly   712 DKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIAC 776

Human   899 KVDSLTLLKCGENTS--------------PVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGK 949
            ...|.::......||              |:.....::|:.::|....|  ......||..:...
  Fly   777 STPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPG--MAATSSSDAGNLSF 839

Human   950 GFASRENRRNNGLSGKCLQEAQEEGN---------------SILPERRGRPEISLDERGEGGHVH 999
            |.:|.:...|..|:...|....:.|:               |..|.|..:.:.|.:...:.....
  Fly   840 GESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQ 904

Human  1000 TSDD-------------SEVVFSSCDLNLTMED-----SDGVTYALKCDSSG-----HAPEIVST 1041
            ..||             :......|||   .||     ..|||.|:..|...     ..|:.|..
  Fly   905 EDDDDPNKLWCICRQPHNNRFMICCDL---CEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKR 966

Human  1042 VHE-------DYSGSSESSNDESDSEDT----------DSDDSSIPRNRLQSVVVVPKN-STLPM 1088
            ..|       |...:..::..|....:|          .....|.||..|..|:.|..: ..:||
  Fly   967 QEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPM 1031

Human  1089 EETS---------------------------------------PCSSRS----SQSYRHYS---- 1106
            .:.:                                       |.|:.|    .:..|.|:    
  Fly  1032 AKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRKYAQSAI 1096

Human  1107 --------------------DHWEDERLESRRHLYEE---------------KFES-----IASK 1131
                                ::..|.:...::.|:|:               .||.     |...
  Fly  1097 QAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGH 1161

Human  1132 ACPQTDKFFLHKGTEKNPEISFTQSSRKQ---IDNRL-----------------------PE--- 1167
            ..|...:|  .|..::||......|...|   .:.||                       ||   
  Fly  1162 MAPSAHQF--RKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPA 1224

Human  1168 -LSHPQSDGVDSTSHTDVKS-DPLGHPNSEE---TVKAKIPSR----------------QQEELP 1211
             |||||:..|.::....:.| .||...:.|:   ||:|..|:|                .:|:|.
  Fly  1225 KLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLL 1289

Human  1212 IYSSDFEDVPNKSWQQTTFQNRP-----DSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFS 1271
            ....:.:.....|.|.||  ..|     |..:...||...:|  .....|.....:.|:|.::..
  Fly  1290 ARIKEAQAAEENSGQPTT--QWPTVLEVDQFVKNVELEMFNS--FGRDVGAKYKAKYRSLMFNIK 1350

Human  1272 QEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVP 1336
            ..|..|.:::      .|        |:|.             :||            :.....|
  Fly  1351 DRKNRTLFEK------IC--------AKQV-------------EPR------------QLVRMTP 1376

Human  1337 DSLTDDREEEENWDQQDGSHFSDQSDKFLLSL---------QKDKG--------SVQAPE--ISS 1382
            :.|..  :|...|.:::..|..|...|..|.|         :..||        .|..||  :|.
  Fly  1377 EQLAS--QELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSE 1439

Human  1383 NS----IKDTLAVNEKKDFSKNLEKNDIKDR-GPLKKR---------RQEIESDSESDGELQDRK 1433
            .|    .|.|..|:|..  :..||::..::: |..|::         |:...|.|.|.|...|::
  Fly  1440 ASSMADTKQTSLVSEPS--TSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKR 1502

Human  1434 KVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKS 1498
            ..|...|.||   .|||.              :|                       ..|.:.|.
  Fly  1503 HRRQHNEGGE---QPGSG--------------ER-----------------------EHRSREKQ 1527

Human  1499 HRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHAD---- 1559
            .|:...:.....|..:||..|..:                         ..:..::|..|.    
  Fly  1528 SRERDEIVPSPLPKKRDENDQSPV-------------------------PKKTAEKKTEASAYNL 1567

Human  1560 VEVILTEKK--------GWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMA 1616
            |:.||..:|        |....:.|.||:....|: ..|.:|:         |:|      |...
  Fly  1568 VDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLK-APEPMDN---------YSR------YLHG 1616

Human  1617 LKNDEIIDATQK---------------GNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1666
            |....:...|.|               |||.:..|                          |:||
  Fly  1617 LTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGN--------------------------LMPS 1655

Human  1667 GSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALM 1731
            ..::                          :|...||::.....|:||..::         |.::
  Fly  1656 QMDV--------------------------IGRITRVNVWEYIKKLKKSPTK---------EVVI 1685

Human  1732 ENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLE-RHGLSLLWI------ 1789
            .|         :...|.                  ..|:.......:|: |..|.:|.:      
  Fly  1686 VN---------IFPASP------------------SETYKFDLFFEYLDSRQRLGVLGVDSDQIR 1723

Human  1790 --WMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESK----VLPIIQRWSQTK--------- 1839
              ::..||.|.:....||     |.|  |:|   ..||::    :|.||.|....:         
  Fly  1724 DFYIFPLGSGDKLPPALQ-----TAE--PVP---FYEEAQRPNTLLGIIVRCLSKRPADAVPSTP 1778

Human  1840 ---TAVPPLSEGDGYSSENTSRAHTPLNTP---DPSTKLSTEADTDTPKKLMFRRLKIISENSMD 1898
               |.||.|      ||:...|:.:.::.|   .|..|:||.:.:                    
  Fly  1779 SVPTPVPAL------SSKVAKRSRSSISYPAQSSPKRKISTHSTS-------------------- 1817

Human  1899 SAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPE 1963
                       .||.:.|:|.:...|:     .:.|:..|:.:|:..|.::.:     .|.|...
  Fly  1818 -----------SKDDEFDIDAIIKAPI-----AKLQKTAPKVVPQPSVPNDAD-----EPYSPGG 1861

Human  1964 ADAEIEPK-ESNGTKLEEPINE----ETPSQDEEEGVSDVESERSQEQPDKTVDISDLA--TKLL 2021
            :|.|:.|. ......||..:||    ....|.|..|:..||...|....:....||..|  :|:|
  Fly  1862 SDDELVPSAPQRPNDLERQVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAISIPANLSKIL 1926

Human  2022 DSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRR 2086
            .|.||                                    ||...|...|.|::          
  Fly  1927 ASIKD------------------------------------KTNLPSSADDGDEE---------- 1945

Human  2087 SSLSPPSSAYERGTKRPDDRYDTPTS--KKKVRIKDR-NKLSTEERRKLFEQEVA---QREAQKQ 2145
                          ..|:|.....:|  .||.|.|.| ..||..|...:....:|   .|.::.:
  Fly  1946 --------------YNPEDDITATSSFASKKPRSKGRLAHLSEAELLSMVPDNLAGVIPRSSRTR 1996

Human  2146 QQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPG 2178
            .|..|:....:|||        |..|    |||
  Fly  1997 HQLAQSPLTPTPLP--------PPPP----PPG 2017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SETD2XP_011531934.1 AWS 1503..1557 CDD:197795 5/53 (9%)
SET 1558..1681 CDD:214614 25/149 (17%)
PostSET 1682..1698 CDD:214703 0/15 (0%)
Asp-B-Hydro_N <1948..2131 CDD:191249 39/192 (20%)
WW 2399..2428 CDD:278809
SRI 2477..2556 CDD:285448
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 25/140 (18%)
PHD_PHF3_like 914..963 CDD:277027 11/51 (22%)
BRK 1142..1186 CDD:197800 9/45 (20%)
TFIIS_M 1274..1396 CDD:284835 26/166 (16%)
SPOC 1623..1729 CDD:285043 23/193 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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