DRSC/TRiP Functional Genomics Resources

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Protein Alignment SETD2 and Set2

DIOPT Version :10

Sequence 1:NP_054878.5 Gene:SETD2 / 29072 HGNCID:18420 Length:2564 Species:Homo sapiens
Sequence 2:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster


Alignment Length:2901 Identity:637/2901 - (21%)
Similarity:1025/2901 - (35%) Gaps:996/2901 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    89 LTALGNE--------KQSDTPNPPAVPLQVDSTPK----------MKMEIGDTLSTAEESSPPKS 135
            |:||||.        |.:|....|..|...||...          :|.::.|.|:        |:
  Fly    28 LSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLN--------KN 84

Human   136 RVELGKIHFKKHLLHVTSR----PLL----ATTTAVASPPTHAAPLPAVIAESTTVD-------- 184
            |        |.|.:.:.:|    |..    :.|||.::..:.|....|..:.:.||.        
  Fly    85 R--------KAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEM 141

Human   185 SPPSSPPPPPPPAQATTLSSPAP---------VTEPVAL--PHTPITVLMAAPVPLP-------- 230
            |..|.|||||||......:.|.|         .:||.|:  .| |:..:...|...|        
  Fly   142 SHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAH-PVQTMAGLPPVTPRKRGRPRK 205

Human   231 ---VDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEI 292
               .|.|:     .|.:|||...::||...:.:.|         |..:|            ..|:
  Fly   206 SQLADAAI-----IPTVIVPSCSDSDTNSTSTTTS---------NMSSD------------SGEL 244

Human   293 P------DSSKISLSCK--KTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKER 349
            |      ..||:.:|.|  |.|.:.:||.| |....|.|.|........:.:.|         ||
  Fly   245 PGFPIQKPKSKLRVSLKRLKLGGRLESSDS-GNSPSSSSPEVEPPALQDENAMD---------ER 299

Human   350 DFKKSSAPLKSEDLGKPSRSKTDRD-DKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGS 413
                   |.:.::|.:...::.:.| |....:.::|.::.      :.|.|:...|.        
  Fly   300 -------PKQEQNLSRMVDAEENSDSDSQIIFIEIETESP------KGEEEQEEGRP-------- 343

Human   414 RTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTD-------------NRARESSDSEEEY 465
                  ...|.....|.|....:..|..:      |..|             :......::|||.
  Fly   344 ------VEVEPQDLIDIDMELAKQEPTPD------PEEDLDEIMVEVLSGPPSLWSADDEAEEEE 396

Human   466 KKTYSRRT---------SSHSSSYRDLRTSSYSKSDRDCKT-ETSYLEMERRGKYSSK--LERES 518
            ..|..|.|         |..|:..|..|::..|.|.|..|| |.::.|:...   |||  ||.|.
  Fly   397 DATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAE---SSKQILEAEE 458

Human   519 KRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIK 583
            .:..|.:.|                       .....:.|||:                  .|:.
  Fly   459 SQDQEEQHI-----------------------LIDLIEDTLSE------------------SEVT 482

Human   584 QSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDS 648
            .|.|.:::         .|:.:....|:       |:|.|     :.||:...|.||:       
  Fly   483 SSVSPTIE---------HMVVEEVVVEE-------NQLVD-----EADEILDSKQEFV------- 519

Human   649 IK----ELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSP 709
            ||    |.|:::...|..:           ..|..|:. ||.........::|.|..:|....:.
  Fly   520 IKKVFSESDNIAASLNKDI-----------FEPKVETK-ATCGEVVPRPEMVTEDVYITEGIAAT 572

Human   710 LVKACMLSSNGFQNISRCKEKDLDDTCMLHK--KSESPFRETEPLVSPHQDKLMSMPVMTVDYSK 772
            |.|:.:::....:.|:..|   |.|..::..  |.||..::|| :..|.     |.|.:.:..|:
  Fly   573 LEKSAVVTKPTTEMIAETK---LSDEVVIEPPLKDESDPKQTE-VELPE-----SKPAVNIPKSE 628

Human   773 TVVKEPVDTRVS------CCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLES 831
            .::...|:|..|      || |.:|.....|.:::.|......||:|.:.:|..:..      |.
  Fly   629 RILSAEVETTSSPLVPPECC-TLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAK------ED 686

Human   832 KPVIC---DSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVD 893
            .|...   ::.|.::...|..|:|:.:....:.      |::.:.....|   ..|:..|.:|  
  Fly   687 SPPAAPEEEASNSSEEPNFLLEDYESNQEQVAE------DEMMKCNNQKG---QKQTPLPEMK-- 740

Human   894 SLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKC 958
                    |...||.:.|.|.:|:.|                          ...|.:..:..|.
  Fly   741 --------EPEKPVAETVSKKEKAME--------------------------NPARSSPAIVDKK 771

Human   959 LQEAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDS 1023
            ::..:.|...:...:...||..:|.:                .||         ..||.|.:.:|
  Fly   772 VRAGEMEKKVVKSTKGTVPEKKMDSK----------------KSC---------AAVTPAKQKES 811

Human  1024 SGHAPEIV---STVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSP 1085
            ...|.|.:   .|..|..|...:||:  .::.|....|::....:||:   :||:||.|.:|::|
  Fly   812 GKSAKEAILKKETEKEKSSAKLDSSS--PNTLDKKGKDTAQWSPQLQT---LPKSSTKPPQESAP 871

Human  1086 CSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKA-----CPQTDKFFLHKGTEKNPEISF 1145
                                             |:.||.     .|:.::....||...|...|.
  Fly   872 ---------------------------------SVISKTTSNQPAPKEEQHAAKKGLSDNSPPSV 903

Human  1146 TQSSRKQIDN------------------RLPELSHPQSDGVDSTSHTDVKSDP---LGHPNSEET 1189
            .::..|.:..                  ||.|.:..:...|.:......|.:|   :..|..:::
  Fly   904 LKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKS 968

Human  1190 VKAKIPSRQQEELPIYSSDFEDVPN---------KSWQQTTFQN--RPDSRLGKTELSFSSSCEI 1243
            :..|...|:       ::.:||.||         .|.|..|...  :|.....|.....|:.||.
  Fly   969 LSGKTSLRR-------NTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEA 1026

Human  1244 PHVDGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDP 1308
              ...|.||........:.:...|.:|  ..|||....|..:...:.:  ||::        .|.
  Fly  1027 --AKDLRSSSSSSTPTREVAASSPVST--SSDSSSKRNGSKRTTSDLD--GGSK--------LDQ 1077

Human  1309 R-----SGRPPGTGVVYDRTQ-----------GQVPDSLTDD-------REEEENWDQQ---DGS 1347
            |     ..|.|.|.:....|:           ..:.|:|...       :|.:|:..:|   |.|
  Fly  1078 RRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSS 1142

Human  1348 HFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDT-----------------------LAVNEKKDF 1389
            ..:.|.       ...|.::::.||.|.::.:|                       .|.|...|.
  Fly  1143 SSASQG-------APKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDI 1200

Human  1390 SK------NLEKNDIKDRGPLKKRRQEI--ESDSESDGELQDRKKVRVEVEQGETSVPPGSALVG 1446
            :|      ||.|.|..|....|:.:.|:  |:|.|.| |...|.   ..:|...|:..|......
  Fly  1201 AKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEED-EFAQRV---ANMETPATTPTPSPTQSN 1261

Human  1447 P------SCVMDDF------RDPQRWKE-----CAKQGK-------MPC---------------- 1471
            |      :.|:.:.      |...|.|:     .|.||:       .|.                
  Fly  1262 PEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAIN 1326

Human  1472 ----------YFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLM 1526
                      .|.|::||.|...|:.::.:.:   |||:|. |:.||.|||.::||..|:||:||
  Fly  1327 EQFLRSEGLNTFQLLKENFYRCARQVSQENAE---MQCDCF-LTGDEEAQGHLSCGAGCINRMLM 1387

Human  1527 IECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKA 1591
            |||...|.||..|:|:|||:.|.....|..|||||.|:.|...:|...|::||.|||:|.:||:.
  Fly  1388 IECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFER 1452

Human  1592 RVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLV 1656
            |...|::::|.|||||||:.:.:||||.|||.||::||||:||.|||||||||:||:|||:.|.:
  Fly  1453 RQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPI 1517

Human  1657 PSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGE----------------------------- 1692
            ..|.|:|||||:.|||::||:|:|.:|||||::|||                             
  Fly  1518 QPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPE 1582

Human  1693 ---NRVSIRA------------AGGKMKKERSRKKD-----------SVDG-------------- 1717
               .|.|.:|            |.|:.:||:::.||           |..|              
  Fly  1583 EGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAGRWLKPSATGSSSSAEKPPKKPKV 1647

Human  1718 -ELEALMENGE-----------GLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQ-SCLKS 1769
             :.:|::|:.:           ||.::...|..||.:||.:.|:.:|..|.::  ||.: .|.:.
  Fly  1648 NKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVL--THGELPCRRL 1710

Human  1770 FLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAV 1834
            ||:.|||.||..|::|.|    ::.:|:|.::.|||.||||.:.||.:|:|...:|.||      
  Fly  1711 FLDYHGLRLLHAWISENG----NDDQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWS------ 1765

Human  1835 PPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSE 1899
                                                                ||::         
  Fly  1766 ----------------------------------------------------NSLE--------- 1769

Human  1900 LEGKDGKEDLDQLENVPVEEEEELQSQQ--LLP--QQLPEC-KVDSETNIEASKLPTSEPEADAE 1959
                      .||..||.|::..|..:.  ||.  |.|||. ::.....||..|  ..|.|||.:
  Fly  1770 ----------QQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMK--EHEREADRQ 1822

Human  1960 IEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQE-QPDKTVDISDLATKLLDSWKDLKEVY 2023
                       ::.::..|..:|:.|..|..:..|... :.|.|..                   
  Fly  1823 -----------QKHVHASTALEDQRERESSNDRFRQDRFRRDTTSS------------------- 1857

Human  2024 RIPKKSQTEKEN-----TTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSP 2083
            ||.|..:....|     ||.::|.:..                   ||..|:|  ..:|||.:.|
  Fly  1858 RIGKPIRMSGNNTICTITTQQKGSNGA-------------------PDGMTRN--DNRRRSDIGP 1901

Human  2084 PSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTS 2148
            ||                         :.|..||.|.||.|||::||..||:::......|....
  Fly  1902 PS-------------------------EQRRTLSKELRRSLFERKVALDEAERRVCTEDRLEHEL 1941

Human  2149 PLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSN-PNAGKVLLPTPSMDPVCSPA----PYDHAQP 2208
            ...:.....|..       |...|.....|.:. .|:..|.:|.|....:.:.|    ..|..| 
  Fly  1942 RCEFFGADINTD-------PKQLPFYQKTDTNEWFNSDDVPVPAPPRTELLTKALLSPDIDVGQ- 1998

Human  2209 LVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVW 2273
              |.:......||.|..:|        .:..:...|||.::.                   |:: 
  Fly  1999 --GATDVEYKLPPGVDPLP--------PAWNWQVTSDGDIYY-------------------YNL- 2033

Human  2274 DSNQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQ------------SYAQP 2326
               ::.:|..:..||.|...|:..:..|...::.:     |..|.:::            |.:..
  Fly  2034 ---RERISQWEPPSPEQRLQTLLEENTTQQPLHEL-----QIDPAVLENELIQVDTDYVGSLSAK 2090

Human  2327 SL-QYIQGQ-------------QIFTAHP--------------------------------QGVV 2345
            || |||:.:             .|....|                                :.:.
  Fly  2091 SLAQYIEAKVRERRDLRRSKLVSIRLISPRRDEDRLYNQLESRKYKENKEKIRRRKELYRRRKIE 2155

Human  2346 VQPAAAVTTIVAPGQPQPLQP-----SEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKI 2405
            |.| .||..|..||:..|:||     .|.......::.|.....:....:.|.....|....|| 
  Fly  2156 VLP-DAVDEIPVPGKALPIQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPSTSHAAMAALGK- 2218

Human  2406 YYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPM------------KASKKPKTA 2458
                .:.:.|                      .|||....:.||            :.|||.|::
  Fly  2219 ----AVAQPT----------------------GLGTVGKRKLPMPPSVTVKKHRQEQRSKKVKSS 2257

Human  2459 EADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKY 2523
            ::..::..|:::.|.||.|:|..:...|.||||..|.:||||:.||:|.|..:|::.:..||::|
  Fly  2258 QSPLTATSAREAHEKFRFEISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHITTKEMRY 2322

Human  2524 CK---NPEDLECNENVKHKTKEYIKKYMQKFGAVY-KPKED 2560
            |:   ||  |.|.|:||||:.::|.:||::.|.|| ||.|:
  Fly  2323 CEVSGNP--LSCTESVKHKSYDFINQYMRQKGPVYKKPAEN 2361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SETD2NP_054878.5 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..211 13/47 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..561 61/322 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..626 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..995 4/30 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1036..1101 15/64 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1133..1233 22/131 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1352 21/113 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1393..1443 15/51 (29%)
Interaction with TUBA1A. /evidence=ECO:0000269|PubMed:27518565 1418..1714 139/400 (35%)
AWS 1495..1549 CDD:197795 28/53 (53%)
SET_SETD2 1549..1690 CDD:380949 77/140 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1831..1872 0/40 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1921..2142 51/231 (22%)
Low charge region. /evidence=ECO:0000269|PubMed:16118227 2137..2366 45/291 (15%)
WW 2391..2420 CDD:459800 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2439..2465 9/37 (24%)
Interaction with POLR2A. /evidence=ECO:0000269|PubMed:16314571 2457..2564 43/108 (40%)
SRI 2467..2555 CDD:462404 38/90 (42%)
Set2NP_572888.2 valS <709..832 CDD:237855 30/192 (16%)
AWS 1358..1410 CDD:197795 28/55 (51%)
SET_SETD2 1410..1551 CDD:380949 77/140 (55%)
WW 2014..2043 CDD:459800 6/59 (10%)
SRI 2266..2355 CDD:462404 38/90 (42%)
Blue background indicates that the domain is not in the aligned region.

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