DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD2 and set2

DIOPT Version :9

Sequence 1:	XP_011531934.1	Gene:	SETD2 / 29072	HGNCID:	18420	Length:	2572	Species:	Homo sapiens
Sequence 2:	NP_594980.1	Gene:	set2 / 2542070	PomBaseID:	SPAC29B12.02c	Length:	798	Species:	Schizosaccharomyces pombe

Alignment Length:	871	Identity:	225/871 - (25%)
Similarity:	355/871 - (40%)	Gaps:	229/871 - (26%)

- Green bases have known domain annotations that are detailed below.

Human  1346 EENWDQQDGSHFSDQSDKFLLSLQKDKGSVQA--PEISSNSIKDTLAVNEKKDFSKNLEKNDIKD 1408
            |||.|::.             |..||..:|||  ...||:|..|.    |.|:.::.:.| |...
pombe    15 EENVDRKS-------------SWSKDTIAVQAVGSSPSSSSSHDF----ESKEDAEGMNK-DESA 61

Human  1409 RGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPP------GSALVGPSCVMDDFRDPQR 1467
            ..|.........|.|:|       |.||.|      ::||      .||   ....:..|.:.|
pombe    62 PSPSTSSPSSASSRSQS-------KYVRKE------ALPPQLFHHLDSA---KDKALTTFEEIQ- 109

Human  1468 WKEC----AKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQG-EIAC--G 1525
              ||    |..||.|       ||               :.|.|:|.|...|    | .:||  |
pombe   110 --ECQYASANIGKPP-------EN---------------EAMICDCRPHWVD----GVNVACGHG 146

Human  1526 EDCLNRLLMIECSSR---CPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEY 1587
            .:|:||:..|||:..   |  |..|.|:||||.:.|.|:|.||||||:||||..:||.:|||.||
pombe   147 SNCINRMTSIECTDEDNVC--GPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEY 209

Human  1588 CGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNG 1652
            .|||:..::|:.|:::|......|:|||.|:..|.||||::|:.:||.||||.|||...||.|..
pombe   210 IGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWMVGD 274

Human  1653 QLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRV--------SIRAAG 1709
            :||:|.|..:.:..|.||||||...|||.:||.|:||...|.||:||:.:.        ::|.|.
pombe   275 KLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIGGKTQTEAQSKLPENVREAL 339

Human  1710 GKMKKE---------RSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLM-VRIETLEQKLT--C 1762
            |...:|         |.|:|..:| |...::|..:.....::  |.:::: |.::|.:..||  .
pombe   340 GIEDEEDSWENITARRQRRKKGID-ETSKIIEEVQPTPLTSE--SATKVIGVLLQTKDDLLTRKL 401

Human  1763 LELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEI------IKTLEHLPIPTKN 1821
            :|.|..|...|..:|.:...|.::..:.:          :|...:|      |||:...|..|:|
pombe   402 MERIFLTSDPSVCRSIIALRGYNIFGLML----------KKFSIDIEFILRSIKTMLSWPRLTRN 456

Human  1822 MLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMF 1886
            .:::|.:.|::|.:..
pombe   457 KIQDSNIEPVVQEFCD------------------------------------------------- 472

Human  1887 RRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETN 1951
                  .||.            |.||..:.|       ::|.|.|:....:|::.|.......||
pombe   473 ------HENE------------EVKDHAKTL-------LKEWESLEIAYRIPRRKPGQVAPQSTN 512

Human  1952 IEASKLPTSEPEADAEIEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDL 2016
            .|.|...::.|..|.  ||:..:...::..||..|  :|..:....:.|.|..:...::...:|.
pombe   513 AEPSNNQSNPPLRDQ--EPQRGDKGDIKSAINNST--EDLSKKHPALHSSRPSDSRSRSKFGNDY 573

Human  2017 ATKLLDSWKDLKEVYRIPKK-----SQTEKENTTTERGRDAVGFRDQ--------TPAPKTPN-- 2066
            .:   .|..:|......||:     |.|..|.||....::.|..:..        :.|.::.|
pombe   574 QS---HSKHNLFRKNSFPKRRRLSNSDTPSETTTPNNEQEQVSNQANKVDLNKIISAAMESVNQK 635

Human  2067 ---RSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDR-YDTPTSKKKVRIKDRNKLSTE 2127
               ::::.:.::..|.|.:.|||       .|||...||...: ::..|...:....|.:..|..
pombe   636 NVLKAQKEEEERIAQQKREEKRR-------LAYEESLKRHAKKLHEKKTKSSQDATIDHHLTSHS 693

Human  2128 ERRKLFEQEVAQREAQKQQQQMQNLG 2153
            .....|:..:|:..|.|..:..:.||
pombe   694 PESIAFKAVLAKFFANKTARYQEKLG 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SETD2	XP_011531934.1	AWS	1503..1557	CDD:197795	23/59 (39%)
		SET	1558..1681	CDD:214614	62/122 (51%)
		PostSET	1682..1698	CDD:214703	8/15 (53%)
		Asp-B-Hydro_N	<1948..2131	CDD:191249	40/201 (20%)
		WW	2399..2428	CDD:278809
		SRI	2477..2556	CDD:285448
set2	NP_594980.1	AWS	125..179	CDD:197795	23/59 (39%)
		SET	180..303	CDD:214614	62/122 (51%)
		SET	275..791	CDD:225491	113/546 (21%)
		PostSET	304..320	CDD:214703	8/15 (53%)
		Med26	440..489	CDD:285873	15/122 (12%)
		SRI	699..771	CDD:285448	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	116	1.000	Domainoid score	I1751
eggNOG	1	0.900	-	-		E2759_KOG4442
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002762
OrthoInspector	1	1.000	-	-		oto146087
orthoMCL	1	0.900	-	-		OOG6_102278
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740