DRSC/TRiP Functional Genomics Resources

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Protein Alignment SETD2 and met-1

DIOPT Version :10

Sequence 1:NP_054878.5 Gene:SETD2 / 29072 HGNCID:18420 Length:2564 Species:Homo sapiens
Sequence 2:NP_491340.2 Gene:met-1 / 172026 WormBaseID:WBGene00016603 Length:1604 Species:Caenorhabditis elegans


Alignment Length:1973 Identity:390/1973 - (19%)
Similarity:667/1973 - (33%) Gaps:745/1973 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   887 PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRN 951
            ||.||.|:.||.....:::.|.|.:|...:|.:              |.|.:....|..:|    
 Worm    54 PPKIKTDANTLNTPSTSSNLVDDKLLIESESQD--------------SILTNEADSFLEKE---- 100

Human   952 NGLSGKCLQEAQEEGNSILPERRGRPE---------------ISLDERGEGGHVH---------- 991
                    .|..|:.:.|||::...||               :..||..:...|:          
 Worm   101 --------VEEIEDSSDILPDKINSPEKPSVLVKRRSSTRLKVKTDEDEKDVPVNIEVAVLEEKS 157

Human   992 -----TS----DDSEVVFSSCDLNLTMED----------SDGVTYALKCDSSGHAPEIVSTVHED 1037
                 ||    :|.:...||..|...:||          :|.....:|.:.......::.....|
 Worm   158 IQIEPTSPAHPEDPQPSTSSLPLVEPIEDIVEPNEPTSSADPPVSNIKDEDIKEEEPLIKKPASD 222

Human  1038 YSGSSESSNDES--DSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSP------------CSS 1088
            .|.|.:.:|.||  ||:.:::|..:||            :.::|:.:|.|            ...
 Worm   223 ESESMDIANSESGNDSDSSEADPRTIP------------SFSIPLPDTPPPNFAKRGEIHVDVDQ 275

Human  1089 RSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSS---- 1149
            ::|:........||..|.:|..:       .::|....:....|||...:     |||..|    
 Worm   276 KNSKQSGESQSPWERAREKSASN-------PLSSPTMSRPRIHFLHPAYQ-----SFTNDSVSPL 328

Human  1150 ----------RKQIDN--------------RLPEL---------SHPQSDGVDST-------SHT 1174
                      |::::|              .:|.|         |.|.|..|.|:       |.|
 Worm   329 PPPPPEPAPAREKVENGGPTTFKMTFKKAANIPILKTSAFEQPSSPPPSSSVSSSISLSEVNSST 393

Human  1175 DVKSDPLGHP-----NSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRP-------- 1226
            .:.|:  ..|     |.:.|...::|..|..|||               :.:|.|.|        
 Worm   394 SIASE--SSPAKRSSNFDLTASNELPPPQMVELP---------------KLSFFNMPPAVRSAED 441

Human  1227 DSRLGKTE---LSFSSSCEIPHVDGLH---------SSEELRNLGWDFSQEKPSTTY-QQPDSSY 1278
            ||.:...|   |..|.:...|..|.|.         :..|::.|  ..:.||.:... ::.||..
 Worm   442 DSAMTSEEPILLLRSPNSATPDDDALFLTTPPPPKMTESEIQAL--KVATEKVNQVIARREDSEK 504

Human  1279 GACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDREEEENWDQ 1343
            ..    :::::.:.|...||      ..|.||          .:|..:..|.....||::|...:
 Worm   505 DV----RHREDRDDYDRRRD------DRDRRS----------RKTDSERNDQRGRQREDDERRAR 549

Human  1344 QDGSHFSDQSDK----FLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEK-NDIKDRGP 1403
            :.....:.:.|:    ..|..|||:                  ...|||..:.::| ||      
 Worm   550 EREREVTKRHDREREEMRLQKQKDE------------------ERRKKDEEERIQKEND------ 590

Human  1404 LKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGK 1468
             :|:::|.|:..|     :::||::.|    |..:|.                            
 Worm   591 -EKKQKEDEAKME-----EEKKKIKEE----EMKIPE---------------------------- 617

Human  1469 MPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGED-CLNRLLMIECSSR 1532
                |:||.|:.|||   :|.:.:..:.:.|||      .|..|.  |.:: |:||.::.||.|.
 Worm   618 ----FELISESKYLT---RNANKKKTESLTCEC------HRTGGN--CSDNTCVNRAMLTECPSS 667

Human  1533 CPNGDYCSNRRFQRKQHADVEVILT-EKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEY 1596
            |.  ..|.|:||.:|::|.||...| ..||.||||.||:....|::||.|||::..:::.|..:|
 Worm   668 CQ--VKCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKY 730

Human  1597 ARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTV---NGQL-RVGFFTTKLVP 1657
            |.:|...::::.......||||..||.|||:||||:||...:||:|   .|.: |||||:.:.:.
 Worm   731 AADKKHKHHYLCDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIK 795

Human  1658 SGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKD--------- 1713
            :|.|:||||||..||::||:||||||:|.|::            |:..:|.|..:|         
 Worm   796 AGEEITFDYQFVNYGRDAQQCFCGSASCSGWI------------GQKPEEFSSDEDDDIVTTRHI 848

Human  1714 SVDGELEALMENGE--GLSDKNQVLS--LSRLMVR--------------IETLEQKLTCLELIQN 1760
            ::|.|.|..:|..:  |..::|:|:.  |..|::|              :....|::..::.|.:
 Worm   849 NMDEEEEEKLEGLDHLGNHERNEVIKDMLDDLVIRNKKHARKVITIASAMTDYSQRVDVIQEIFS 913

Human  1761 THSQSCLKSFLERHGLSLLWI-WMAELGDGRESNQKLQEEIIKTL--EHLPIPTKN--MLEESKV 1820
            :.:...::.|..:.|::.|.. |::| .|....|.||.:.|:|.|  |......||  :|.:|  
 Worm   914 SDTSVTVQKFYAKEGMATLMAEWLSE-DDYSLDNLKLVQAILKALHTELFDSCAKNDRLLRDS-- 975

Human  1821 LPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMFRRLKIIS 1885
               ..||...|.        |.|..                                   :::|:
 Worm   976 ---TSRWVNAKM--------DEYVD-----------------------------------IQVIA 994

Human  1886 ENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIE----- 1945
            : |:.:.:.|                    ||:|.:::            |||..:..:|     
 Worm   995 D-SLIACVED--------------------PVQEYKDV------------CKVIEKGLVENFTRA 1026

Human  1946 ----------------ASKLPTSEPEADAEIEPKESNGTKLEEPINEETPSQDEEEGVSDVESER 1994
                            :.|:|                 .|:.:|:.::.|.:.|:.    ..|.:
 Worm  1027 KEMAYRLNQYWFNRSVSFKIP-----------------KKIRDPVPKDVPVRQEDA----TTSSQ 1070

Human  1995 SQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQT-----EKENTTT---ERGRDAVGFR--- 2048
            |.:...:||..:                :|....|.:     |:|.:..   ..|.|...:|   
 Worm  1071 SHDNSSRTVSPN----------------HRHHSSSYSNSCYQEREPSHIRFFNNGNDVHQYRFGG 1119

Human  2049 ------DQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKK 2107
                  :.....:.||:...|| .::...:..|.|..|:||.:  |:|   |..|.:|. ..:::
 Worm  1120 YHGNNYNDNYFSRRPNKDSYRD-RRRFNGRRSRSRSRSVSPQN--YKR---RKLDEHDN-NHRQR 1177

Human  2108 VRIKDR-----------NKLSTEERRKLFEQEVAQREAQKQQ-QQMQNLGMTSPLPYDSLGYNAP 2160
            ..|:||           :..|.|...|..:...|:.:..|:. :........:.:|.:...|  |
 Worm  1178 SPIRDRHTSPGGEKTPSSNNSGERNYKRLDIRGARIKTIKEDLEAAAAAAAAAAVPSEVQAY--P 1240

Human  2161 H-----HPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMD--PVCSPAPYDHAQPLVGHSTEPLS 2218
            |     |......|||......||.|   |..:.|.|...  |...|     .||:       :.
 Worm  1241 HEHTAVHQSVYQMPGYESYGVYDPVN---GVYMYPHPGAGYYPPAYP-----QQPI-------ML 1290

Human  2219 APPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQ 2283
            ....:|....:....|.:|.:.:||.|.:|.|:..:                         :.:|
 Worm  1291 TMDTLPPNDRLGELYEKASIEQLAQRDAIVRQELEL-------------------------IRIQ 1330

Human  2284 QQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQP 2348
            .:...||.:|                          :::..:            .|:.:....|.
 Worm  1331 IERKTAQKEA--------------------------IKAACR------------RANEEEAKRQE 1357

Human  2349 AAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITR 2413
            |.|.|..|                                      |..|:...|:.|||:.||:
 Worm  1358 ALAKTKYV--------------------------------------WAIAKSEAGETYYYNKITK 1384

Human  2414 QTQWDPPT----------WESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTA-----EADTS 2463
            :|||..||          ..||.....:..|.       |.:|...:..:||:..     |..:.
 Worm  1385 ETQWTAPTPVQGLLEPACGASPDTTVVIADEI-------TEEEQQAEVLEKPRVVKEEVIEPGSQ 1442

Human  2464 SELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTE------------------------- 2503
            ||..|:|.|..|     .:|..:...|.|..|..|....:                         
 Worm  1443 SETQKESPEKVR-----VVVPKVEVERSPSPKSSRDREKDREKSREKDRERDRDRREGSKHRDSY 1502

Human  2504 ----------------DFKHLARKLTHGVMNKELKYCKNPE------------------------ 2528
                            :|||...:.|...:...|::.::..                        
 Worm  1503 HGHRNGSSSVSERRMREFKHELERSTRSAVRSRLQHQRDASSDKTTWLIKLIYREIFKRESAQSG 1567

Human  2529 -DLECNENVKHKTKEYIKKYMQK 2550
             |...:||...|.|.|:|.|:.:
 Worm  1568 FDYRFSENTDKKVKNYVKSYIDR 1590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SETD2NP_054878.5 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..211
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..561
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..626
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..995 11/64 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1036..1101 15/78 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1133..1233 31/156 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1352 15/88 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1393..1443 12/50 (24%)
Interaction with TUBA1A. /evidence=ECO:0000269|PubMed:27518565 1418..1714 101/310 (33%)
AWS 1495..1549 CDD:197795 18/54 (33%)
SET_SETD2 1549..1690 CDD:380949 66/145 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1831..1872 3/40 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1921..2142 43/270 (16%)
Low charge region. /evidence=ECO:0000269|PubMed:16118227 2137..2366 36/236 (15%)
WW 2391..2420 CDD:459800 11/28 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2439..2465 5/30 (17%)
Interaction with POLR2A. /evidence=ECO:0000269|PubMed:16314571 2457..2564 25/165 (15%)
SRI 2467..2555 CDD:462404 22/150 (15%)
met-1NP_491340.2 PRK12323 <23..263 CDD:481241 49/246 (20%)
AWS 637..682 CDD:197795 18/54 (33%)
SET 682..828 CDD:394802 66/157 (42%)
WW 1366..1393 CDD:238122 12/26 (46%)
Blue background indicates that the domain is not in the aligned region.

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