|
Human 12 MGDFYDPEHPT----------------PE------------EEENEAKIE-NVQKTGFIKGPMFK 47
||||||||:|| || ||:||||.: ::.|..|.|...||
Frog 1 MGDFYDPEYPTESGIDEISAQEEKQSNPEAISLAELPACQQEEDNEAKNDASLAKGTFGKANPFK 65
Human 48 GVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNP-PAVPLQVD 111
|:.||||||||||.||||||||||||||||||||||.|||.|.:|||:||:::.:| || :
Frog 66 GLPSSRFLPKGTKAKVNLEEQGRQKVSFSFSLTKKTFQNRLLNSLGNDKQNESQSPSPA-----E 125
Human 112 STPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAV 176
...|:|:::.|.....||.:..|.:|||||||||||||.||:: |||
Frog 126 HISKLKLDLNDFTGETEEQTLSKPKVELGKIHFKKHLLSVTNK------------------LPA- 171
Human 177 IAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTE--PVALPHTPITVLMAAPVPLPVDVAVRSLK 239
..||||||||.....:||...|: ||..|.:| .....|..:.:.::|..
Frog 172 -----------QPPPPPPPPASLPAPTSPVASTQATPVKQPSSP----EHEEAPAIITLGLQSTN 221
Human 240 EPPIIIVP------------------------ESLEADTKQDTISNSLEEHVTQILNEQADISSK 280
|.|..:|| :|...|.|::::.::||....|.::|:||:|..
Frog 222 EIPPSVVPSQAILTKEVVQGTCDAKESSRSLTDSKGLDKKENSVVSNLETPNNQKVSEKADLSLL 286
Human 281 KEDSHIGKDEEIPDSS---KISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFS 342
||.|||||||:.|.|| |::.|.:|:.||.|.|.|:|..:|||||||||:||||.:||:||
Frog 287 KESSHIGKDEKSPCSSQKPKLNPSPEKSSSKSKFSHSDGAVVGSESDEDSVQTSSSHKSHELK-- 349
Human 343 ASIEKERDFKKSSAPLKSEDLGK--PSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSR- 404
|:..||||.|:||..|:|||.|| .||||..:|:||.:|||.:||:||..|..||:|:|||||
Frog 350 AATSKERDSKRSSVSLRSEDSGKYSSSRSKCTKDEKYSNYSKSDRDSRYSYSHSRSDRDRRRSRS 414
Human 405 -----SHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEE 464
|.|||:|||:::.||||||||||||||||||||||| ||||||.|.|:|||:|||||::
Frog 415 RSRSHSRSRSDRGSKSSSSYSRSERSHYYDSDRRYHRSSPY--RTRYSRSYADSRARDSSDSEDD 477
Human 465 YKKTYSRR------TSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSE 523
:::|:||. :||||||||:.|||||||.|||.|.::|| :::|||:.:|:.||:.:|:||
Frog 478 HRRTHSRSSDSRRPSSSHSSSYRESRTSSYSKYDRDSKGDSSY-DLDRRGRDTSRHERDFRRSSE 541
Human 524 NEAIK----RCCSPPNELGFRRGSSYSKHDSSAS---------RYKSTLSKP------------- 562
.|..| |..||..|...:|..|:||.|:|.: .:.::::||
Frog 542 KEPSKKASPRKASPKKEAEEKREWSHSKADNSGNAGSKSGSKQEHSNSVTKPSKWDMEKKPTQSA 606
Human 563 -------------IPKSDKFKNSFCCTELNEEIKQSHS-----------FSLQTPCSKGSELRMI 603
:..|:..|.||...:........|| |:.:..||..:..:|:
Frog 607 IEKEEHKKGKDEVLSSSNVKKTSFPAHQQTSPPYSKHSDHFTSSSPGPEFTQERDCSSQTAKKML 671
Human 604 NK------------------------------------------NPEREKAGS------------ 614
:. .||.....|
Frog 672 HTTSGSKYDDEDDDKQHKSPFQGIYNLSPSETWDLVTLSTTEDLEPEEHTTSSDNCRSDAYGKDS 736
Human 615 ----PAP---------SNRLN---------DSPTLKKLDEL-----------------PIFKSEF 640
|:| :|::: :||...|::|| ....|:.
Frog 737 DDSQPSPHKVTKLHTRTNKISEDLQASKSTESPQKPKINELHPRTHKVSDDWQPRTHKVSDSSQH 801
Human 641 ITHDSHD--SIKELDSLS----KVKND----QLRSFCPIELNI---------------------- 673
.||...| |.|..|.|. ||.:| ..::...:||.|
Frog 802 RTHKVCDDRSCKTSDDLQPTTYKVSDDLQPRPHKTSDDLELRIHKNEDDPRTLKANEDSWTRTHK 866
Human 674 ---NGSPGA--ESDLATFCTSKTDAVLMT-----SDDSVTGS--------ELSPLVKACMLS--- 717
|..|.: ||......|.|..|...| |:||.:.| ..|..|.....|
Frog 867 VSDNSQPRSHKESHNMQLRTHKASADTQTKTHKVSEDSQSRSYRVSEDSQSRSHKVSEDSQSRSH 931
Human 718 --SNGFQNISRCKEKDL------------------------------------------------ 732
|...|:.|....:||
Frog 932 KVSEDSQSRSHKVSEDLQSRSLKLSEDSQPRSYKVSEDSQPRSYKVSEDSQPRSHKVSEDSQPRS 996
Human 733 ------------------------------------------------------------DDTCM 737
|....
Frog 997 HKVSEDSQPRSHKVSEDSQPRSHKVSEDSQPRSHKVSEDSQSRSHKVSEDSQSRSHKVSEDSQSR 1061
Human 738 LHKKSESP-------------------------------------FRETEPLVSPHQDKLMSMPV 765
.||.||.| |:||:.| .|: :|.
Frog 1062 SHKVSEDPQPKTPKKIDNQRPRTPEIIDDLQPSTPKETDNAQPRTFKETDDL--QHR-----LPY 1119
Human 766 MTVDYSK-----------TVVKEPVDTRVSCCKTKD----------SDIYCTLN---------DS 800
...|..: .:.||..|.:....|..| :.::...| ||
Frog 1120 AAEDMQQRSANASDNTHPKIPKEGEDPKPRTSKVNDGFQPKDHKDGNHLHSETNTIADSVDHDDS 1184
Human 801 NPSLCNSEAENIEPS---VMKISSNSFMNVHL---------------ESKPVI------------ 835
:|. .:...:..||| |.||:....:.|.: .|.||:
Frog 1185 HPQ-THILIDGSEPSTNEVFKINKPDTVGVQIPIEEVDLPHDSTEIKASIPVVEHLEKSLEQCEE 1248
Human 836 -------CDSRNL-TDHSKFACEEYKQSIG-----------STSSASV---------NHFDDLYQ 872
|.||.| ||.|:...::|.:.:. .:..||| |.|:
Frog 1249 VEVTLAKCPSRTLETDASEMLIDKYLEHVHKPETCHSVPECQSEMASVRTDPTTEEQNEFE---- 1309
Human 873 PIGSSGIASSLQS---------------LPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLK 922
:|..|.|..|:: ||.||.| .|.|:..:...:...|: :.
Frog 1310 -MGQKGTAELLKASINLNQDLPGQVSGHLPEGISV--------AEETAISVAIPISENKN---VV 1362
Human 923 HAGKETIVEVGSDLPDS-GKGFASRENRRNNGLSGKCLQEAQ-EEGNSILP-ERRGRPEISLDER 984
.:|..|...||:| || |........:.:..|....|.:.| .|..||.. |...:|..::||
Frog 1363 QSGNTTPFNVGAD--DSQGSSTPDTLGKESPSLDEPALVDIQATERKSIYSFEGIDQPSEAVDE- 1424
Human 985 GEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGS-----SES 1044
.|..|.||...| :|:| .:.||..::.|.: :.:::.|||:.|: |:|
Frog 1425 ------ETKLDKEVETKS-ELHL----ENCVTEEIQRDPT----QTLNSKHEDFIGAINDFYSDS 1474
Human 1045 SNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESR 1109
.:.|||:|||||||||:||||||||||:|:|||:..||. | ||....:..||..|.:..||:
Frog 1475 EDSESDTEDTDSDDSSLPRNRLQSVVVIPQNSTIANEEL--C--RSPYESQTLSDSCETDVAESK 1535
Human 1110 RHLYEEKFESIASKAC-PQTDKFFLHKGTEKNPEISFTQSSRKQIDNRLPELSHPQSDGVDSTS- 1172
....|...:.:..|.| |.. |.:::..|....::.::.:. ||. :|.||.|||
Frog 1536 SVSAEVVQKRVVDKECSPPA------KSSDEVLEDLRAKALKESVS--LPR----RSVGVVSTSQ 1588
Human 1173 ------------HTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFED----VPNKSWQQTT 1221
||:.|:: |.....|.:..: .::.:::.:|...|:. .|:.|.::..
Frog 1589 PEVIARIRSGENHTEYKAE---HETPTSTNRTGL-QKENDKVELYKPSFDQSYQHSPSNSAKKPD 1649
Human 1222 F-----QNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFSQ-EKPSTTYQQPDSSYGA 1280
| .:.|..|.| :....||..|:|:|..||||||| ||||:||||||||| .
Frog 1650 FFKERLHHEPPKRAG----------DFSRADGFQSAEDLSGLGWDFSQPEKPSSTYQQPDSSY-M 1703
Human 1281 CGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLT---DDREEEENWD 1342
...:.||| .:||...|.:...|||||: ...|..|:|.:..|..|||:| |:.:|:..||
Frog 1704 YVDYNYQQ---AFGGAHVYRKDGDYWDPRA-YEKGAQVMYSKPHGPAPDSVTHCYDEDDEDFGWD 1764
Human 1343 QQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTL----AVNEKKDFSKNLEKNDIKDRGP 1403
...|..:..||: ....:..||||.||||||.|..: |:.|:. :|..::.|:|:|||
Frog 1765 TDHGQTYPVQSE----LAYNESSSVQAHEISSNSTKMVVVAPKAIPEQP--AKTSDRLDMKERGP 1823
Human 1404 LKKRRQEIESDSESDGE-LQDRKKVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQG 1467
.||||||:|:|.|:|.| |:.:.|:...::|...|. .|.||||||.|.||:|::||
Frog 1824 PKKRRQELENDYENDLEALEKKHKMEAALKQDVASY---------LCNMDDFRDSQHWKDCSRQG 1879
Human 1468 KMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSR 1532
|||.:|||||||||||||||:|||||||||||||..|||:|||||::||||||||||||||||||
Frog 1880 KMPPFFDLIEENVYLTERKKSKSHRDIKRMQCECPVLSKEERAQGQVACGEDCLNRLLMIECSSR 1944
Human 1533 CPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYA 1597
||||||||||.||:||||.||.||||||||||||||||.|||||||||||||||||||:||||||
Frog 1945 CPNGDYCSNRSFQKKQHAGVEAILTEKKGWGLRAAKDLKSNTFVLEYCGEVLDHKEFKSRVKEYA 2009
Human 1598 RNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSEL 1662
||||||||||||||||||||||||||||||||||:|||||||||||||:|||||||::||:||||
Frog 2010 RNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCDPNCETQKWTVNGQVRVGFFTTRVVPAGSEL 2074
Human 1663 TFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGE 1727
||||||||||||||||:||:.||||.||||||||:|||||||||||.||||:||||||||:.|||
Frog 2075 TFDYQFQRYGKEAQKCYCGAPNCRGILGGENRVSVRAAGGKMKKERPRKKDTVDGELEALLGNGE 2139
Human 1728 GLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGR-- 1790
||||||||||||||||||||:|||||||.|::||.|||.||.||:.||||:||||||||||.|
Frog 2140 GLSDKNQVLSLSRLMVRIETVEQKLTCLRLLKNTQSQSYLKWFLDCHGLSVLWIWMAELGDSRGN 2204
Human 1791 -ESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTP 1854
.::.|||.|:|||||.||||.||||||||:|||||||||.|||:|.||||||||||||||||||
Frog 2205 TNNSIKLQLELIKTLEMLPIPNKNMLEESKILPIIQRWSQIKTAIPQLSEGDGYSSENTSRAHTP 2269
Human 1855 LNTP----DPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLD----- 1910
|||| :|:.|||.|||.:||||::.||||||||||||||:|||.||:|.||..|..:
Frog 2270 LNTPSNPTEPAAKLSVEADEETPKKIVLRRLKIISENSMDSAVSDAASEIEVKDVPEKTEVPSVV 2334
Human 1911 QLENVPV----EEEEELQSQQLLP-----------QQLPECKVDSETNIEASKLPTSEPEADAEI 1960
:|::.|: |.:|||:.:..:| :|.|..|.:.:..::..|| || .:.
Frog 2335 ELKDAPLPKQEETKEELKPEGAVPPPVKEDPAATEEQKPIIKTEGDPGVDMCKL---EP---LDA 2393
Human 1961 EPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRI 2025
|.||.||.||:|....|||||||||||||||||||||..||.:|:||||||||:|||||||||||
Frog 2394 EKKEGNGGKLDETSAVETPSQDEEEGVSDVESERSQEPADKILDMSDLATKLLESWKDLKEVYRI 2458
Human 2026 PKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYER 2090
|||:|.||| |.:|.||:.|....| ||:..|.|:||.::|:| ||||.|.||| || .
Frog 2459 PKKTQVEKE--TNDRWRDSSGSTYTT--PKSQGRERDRDLERQSQ----RKRRQSPSPP--AY-Y 2512
Human 2091 GTKRPDD-RYDTP-TSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYD 2153
|:||.:| ||||| :||||.|::||||||||||||||||||||:|||||||||||:|:.||:.|:
Frog 2513 GSKRVEDSRYDTPASSKKKSRLQDRNKLSTEERRKLFEQEVAQKEAQKQQQQMQNMGIASPMTYE 2577
Human 2154 SLGYNA--PHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEP 2216
::.|.| |..||..||.|||:|::|||:||||||||||||.:|.:.||..:|.:|.:| ..|
Frog 2578 AIAYGAQLPPPPFIAYPQGYPLQSFVDPTNPNAGKVLLPTPPLDGIPSPNSFDPSQGMV---VNP 2639
Human 2217 LSAPP-PVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSV 2280
...|| .|.||.|||||::|::.|||.|.:.:|.|:::|||||||||.||..|||.|||.|||:|
Frog 2640 GMMPPQTVSVVQHVAAPMDVTTQQYVTQGETMVPQETNVAVLPVPAPTPVPPQNYGVWDPNQQAV 2704
Human 2281 SV-------QQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFT 2338
:: |.||.||..||.||||||||..:|||.:.|:|..||:|.:|.|..||||.||||:.
Frog 2705 TLQPPQQQSQPQYPPAPPQAAIYYQGQTCQPMYGVPAAYAQPPPPVVPTYTQQGLQYITGQQIYA 2769
Human 2339 AHPQGVVVQPAAAVTTIVAPGQPQPLQPSEM-VVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPE 2402
.||.|||:|...|||||||||||..:|..|| :..||:|||||||||||||||||..||||||||
Frog 2770 PHPPGVVLQQGPAVTTIVAPGQPPAMQQPEMGMAQNNVLDLPPPSPPKPKTIVLPSGWKTARDPE 2834
Human 2403 GKIYYYHVITRQTQWDPPTWESPGDD-ASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSEL 2466
||||||||||||||||||.|:|||:: .:||||||||||||||||||||:|||.|||||||||||
Frog 2835 GKIYYYHVITRQTQWDPPAWDSPGEEGGALEHEAEMDLGTPTYDENPMKSSKKTKTAEADTSSEL 2899
Human 2467 AKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLE 2531
|||||||||||||||||||||||||||||:|||..|||||||||||||||||||||||||||||:
Frog 2900 AKKSKEVFRKEMSQFIVQCLNPYRKPDCKMGRINNTEDFKHLARKLTHGVMNKELKYCKNPEDLD 2964
Human 2532 CNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE 2564
|||||||||||||||||||||.|||||||.::|
Frog 2965 CNENVKHKTKEYIKKYMQKFGTVYKPKEDIDIE 2997
| 
