DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD2 and setd2

DIOPT Version :9

Sequence 1:	XP_011531934.1	Gene:	SETD2 / 29072	HGNCID:	18420	Length:	2572	Species:	Homo sapiens
Sequence 2:	XP_012820433.2	Gene:	setd2 / 100492810	XenbaseID:	XB-GENE-995488	Length:	2997	Species:	Xenopus tropicalis

Alignment Length:	3153	Identity:	1415/3153 - (44%)
Similarity:	1775/3153 - (56%)	Gaps:	748/3153 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    12 MGDFYDPEHPT----------------PEFSWLNG----NREEENEAKIE-NVQKTGFIKGPMFK 55
            ||||||||:||                ||...|..    .:||:||||.: ::.|..|.|...||
Frog     1 MGDFYDPEYPTESGIDEISAQEEKQSNPEAISLAELPACQQEEDNEAKNDASLAKGTFGKANPFK 65

Human    56 GVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNP-PAVPLQVD 119
            |:.||||||||||.||||||||||||||||||||||.|||.|.:|||:||:::.:| ||     :
Frog    66 GLPSSRFLPKGTKAKVNLEEQGRQKVSFSFSLTKKTFQNRLLNSLGNDKQNESQSPSPA-----E 125

Human   120 STPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAV 184
            ...|:|:::.|.....||.:..|.:|||||||||||||.||::                  |||
Frog   126 HISKLKLDLNDFTGETEEQTLSKPKVELGKIHFKKHLLSVTNK------------------LPA- 171

Human   185 IAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTE--PVALPHTPITVLMAAPVPLPVDVAVRSLK 247
                       ..||||||||.....:||...|:  ||..|.:|    .....|..:.:.::|..
Frog   172 -----------QPPPPPPPPASLPAPTSPVASTQATPVKQPSSP----EHEEAPAIITLGLQSTN 221

Human   248 EPPIIIVP------------------------ESLEADTKQDTISNSLEEHVTQILNEQADISSK 288
            |.|..:||                        :|...|.|::::.::||....|.::|:||:|..
Frog   222 EIPPSVVPSQAILTKEVVQGTCDAKESSRSLTDSKGLDKKENSVVSNLETPNNQKVSEKADLSLL 286

Human   289 KEDSHIGKDEEIPDSS---KISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFS 350
            ||.|||||||:.|.||   |::.|.:|:.||.|.|.|:|..:|||||||||:||||.:||:||
Frog   287 KESSHIGKDEKSPCSSQKPKLNPSPEKSSSKSKFSHSDGAVVGSESDEDSVQTSSSHKSHELK-- 349

Human   351 ASIEKERDFKKSSAPLKSEDLGK--PSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSR- 412
            |:..||||.|:||..|:|||.||  .||||..:|:||.:|||.:||:||..|..||:|:|||||
Frog   350 AATSKERDSKRSSVSLRSEDSGKYSSSRSKCTKDEKYSNYSKSDRDSRYSYSHSRSDRDRRRSRS 414

Human   413 -----SHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEE 472
                 |.|||:|||:::.|||||||||||||||||||||||  ||||||.|.|:|||:|||||::
Frog   415 RSRSHSRSRSDRGSKSSSSYSRSERSHYYDSDRRYHRSSPY--RTRYSRSYADSRARDSSDSEDD 477

Human   473 YKKTYSRR------TSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSE 531
            :::|:||.      :||||||||:.|||||||.|||.|.::|| :::|||:.:|:.||:.:|:||
Frog   478 HRRTHSRSSDSRRPSSSHSSSYRESRTSSYSKYDRDSKGDSSY-DLDRRGRDTSRHERDFRRSSE 541

Human   532 NEAIK----RCCSPPNELGFRRGSSYSKHDSSAS---------RYKSTLSKP------------- 570
            .|..|    |..||..|...:|..|:||.|:|.:         .:.::::||
Frog   542 KEPSKKASPRKASPKKEAEEKREWSHSKADNSGNAGSKSGSKQEHSNSVTKPSKWDMEKKPTQSA 606

Human   571 -------------IPKSDKFKNSFCCTELNEEIKQSHS-----------FSLQTPCSKGSELRMI 611
                         :..|:..|.||...:........||           |:.:..||..:..:|:
Frog   607 IEKEEHKKGKDEVLSSSNVKKTSFPAHQQTSPPYSKHSDHFTSSSPGPEFTQERDCSSQTAKKML 671

Human   612 NK------------------------------------------NPEREKAGS------------ 622
            :.                                          .||.....|
Frog   672 HTTSGSKYDDEDDDKQHKSPFQGIYNLSPSETWDLVTLSTTEDLEPEEHTTSSDNCRSDAYGKDS 736

Human   623 ----PAP---------SNRLN---------DSPTLKKLDEL-----------------PIFKSEF 648
                |:|         :|:::         :||...|::||                 ....|:.
Frog   737 DDSQPSPHKVTKLHTRTNKISEDLQASKSTESPQKPKINELHPRTHKVSDDWQPRTHKVSDSSQH 801

Human   649 ITHDSHD--SIKELDSLS----KVKND----QLRSFCPIELNI---------------------- 681
            .||...|  |.|..|.|.    ||.:|    ..::...:||.|
Frog   802 RTHKVCDDRSCKTSDDLQPTTYKVSDDLQPRPHKTSDDLELRIHKNEDDPRTLKANEDSWTRTHK 866

Human   682 ---NGSPGA--ESDLATFCTSKTDAVLMT-----SDDSVTGS--------ELSPLVKACMLS--- 725
               |..|.:  ||......|.|..|...|     |:||.:.|        ..|..|.....|
Frog   867 VSDNSQPRSHKESHNMQLRTHKASADTQTKTHKVSEDSQSRSYRVSEDSQSRSHKVSEDSQSRSH 931

Human   726 --SNGFQNISRCKEKDL------------------------------------------------ 740
              |...|:.|....:||
Frog   932 KVSEDSQSRSHKVSEDLQSRSLKLSEDSQPRSYKVSEDSQPRSYKVSEDSQPRSHKVSEDSQPRS 996

Human   741 ------------------------------------------------------------DDTCM 745
                                                                        |....
Frog   997 HKVSEDSQPRSHKVSEDSQPRSHKVSEDSQPRSHKVSEDSQSRSHKVSEDSQSRSHKVSEDSQSR 1061

Human   746 LHKKSESP-------------------------------------FRETEPLVSPHQDKLMSMPV 773
            .||.||.|                                     |:||:.|  .|:     :|.
Frog  1062 SHKVSEDPQPKTPKKIDNQRPRTPEIIDDLQPSTPKETDNAQPRTFKETDDL--QHR-----LPY 1119

Human   774 MTVDYSK-----------TVVKEPVDTRVSCCKTKD----------SDIYCTLN---------DS 808
            ...|..:           .:.||..|.:....|..|          :.::...|         ||
Frog  1120 AAEDMQQRSANASDNTHPKIPKEGEDPKPRTSKVNDGFQPKDHKDGNHLHSETNTIADSVDHDDS 1184

Human   809 NPSLCNSEAENIEPS---VMKISSNSFMNVHL---------------ESKPVI------------ 843
            :|. .:...:..|||   |.||:....:.|.:               .|.||:
Frog  1185 HPQ-THILIDGSEPSTNEVFKINKPDTVGVQIPIEEVDLPHDSTEIKASIPVVEHLEKSLEQCEE 1248

Human   844 -------CDSRNL-TDHSKFACEEYKQSIG-----------STSSASV---------NHFDDLYQ 880
                   |.||.| ||.|:...::|.:.:.           .:..|||         |.|:
Frog  1249 VEVTLAKCPSRTLETDASEMLIDKYLEHVHKPETCHSVPECQSEMASVRTDPTTEEQNEFE---- 1309

Human   881 PIGSSGIASSLQS---------------LPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLK 930
             :|..|.|..|::               ||.||.|        .|.|:..:...:...|:   :.
Frog  1310 -MGQKGTAELLKASINLNQDLPGQVSGHLPEGISV--------AEETAISVAIPISENKN---VV 1362

Human   931 HAGKETIVEVGSDLPDS-GKGFASRENRRNNGLSGKCLQEAQ-EEGNSILP-ERRGRPEISLDER 992
            .:|..|...||:|  || |........:.:..|....|.:.| .|..||.. |...:|..::||
Frog  1363 QSGNTTPFNVGAD--DSQGSSTPDTLGKESPSLDEPALVDIQATERKSIYSFEGIDQPSEAVDE- 1424

Human   993 GEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGS-----SES 1052
                  .|..|.||...| :|:|    .:.||..::.|.:    :.:::.|||:.|:     |:|
Frog  1425 ------ETKLDKEVETKS-ELHL----ENCVTEEIQRDPT----QTLNSKHEDFIGAINDFYSDS 1474

Human  1053 SNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESR 1117
            .:.|||:|||||||||:||||||||||:|:|||:..||.  |  ||....:..||..|.:..||:
Frog  1475 EDSESDTEDTDSDDSSLPRNRLQSVVVIPQNSTIANEEL--C--RSPYESQTLSDSCETDVAESK 1535

Human  1118 RHLYEEKFESIASKAC-PQTDKFFLHKGTEKNPEISFTQSSRKQIDNRLPELSHPQSDGVDSTS- 1180
            ....|...:.:..|.| |..      |.:::..|....::.::.:.  ||.    :|.||.|||
Frog  1536 SVSAEVVQKRVVDKECSPPA------KSSDEVLEDLRAKALKESVS--LPR----RSVGVVSTSQ 1588

Human  1181 ------------HTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFED----VPNKSWQQTT 1229
                        ||:.|::   |.....|.:..: .::.:::.:|...|:.    .|:.|.::..
Frog  1589 PEVIARIRSGENHTEYKAE---HETPTSTNRTGL-QKENDKVELYKPSFDQSYQHSPSNSAKKPD 1649

Human  1230 F-----QNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFSQ-EKPSTTYQQPDSSYGA 1288
            |     .:.|..|.|          :....||..|:|:|..||||||| ||||:||||||||| .
Frog  1650 FFKERLHHEPPKRAG----------DFSRADGFQSAEDLSGLGWDFSQPEKPSSTYQQPDSSY-M 1703

Human  1289 CGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLT---DDREEEENWD 1350
            ...:.|||   .:||...|.:...|||||: ...|..|:|.:..|..|||:|   |:.:|:..||
Frog  1704 YVDYNYQQ---AFGGAHVYRKDGDYWDPRA-YEKGAQVMYSKPHGPAPDSVTHCYDEDDEDFGWD 1764

Human  1351 QQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTL----AVNEKKDFSKNLEKNDIKDRGP 1411
            ...|..:..||:    ....:..||||.||||||.|..:    |:.|:.  :|..::.|:|:|||
Frog  1765 TDHGQTYPVQSE----LAYNESSSVQAHEISSNSTKMVVVAPKAIPEQP--AKTSDRLDMKERGP 1823

Human  1412 LKKRRQEIESDSESDGE-LQDRKKVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQG 1475
            .||||||:|:|.|:|.| |:.:.|:...::|...|.         .|.||||||.|.||:|::||
Frog  1824 PKKRRQELENDYENDLEALEKKHKMEAALKQDVASY---------LCNMDDFRDSQHWKDCSRQG 1879

Human  1476 KMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSR 1540
            |||.:|||||||||||||||:|||||||||||||..|||:|||||::||||||||||||||||||
Frog  1880 KMPPFFDLIEENVYLTERKKSKSHRDIKRMQCECPVLSKEERAQGQVACGEDCLNRLLMIECSSR 1944

Human  1541 CPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYA 1605
            ||||||||||.||:||||.||.||||||||||||||||.|||||||||||||||||||:||||||
Frog  1945 CPNGDYCSNRSFQKKQHAGVEAILTEKKGWGLRAAKDLKSNTFVLEYCGEVLDHKEFKSRVKEYA 2009

Human  1606 RNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSEL 1670
            ||||||||||||||||||||||||||||||||||:|||||||||||||:|||||||::||:||||
Frog  2010 RNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCDPNCETQKWTVNGQVRVGFFTTRVVPAGSEL 2074

Human  1671 TFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGE 1735
            ||||||||||||||||:||:.||||.||||||||:|||||||||||.||||:||||||||:.|||
Frog  2075 TFDYQFQRYGKEAQKCYCGAPNCRGILGGENRVSVRAAGGKMKKERPRKKDTVDGELEALLGNGE 2139

Human  1736 GLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGR-- 1798
            ||||||||||||||||||||:|||||||.|::||.|||.||.||:.||||:||||||||||.|
Frog  2140 GLSDKNQVLSLSRLMVRIETVEQKLTCLRLLKNTQSQSYLKWFLDCHGLSVLWIWMAELGDSRGN 2204

Human  1799 -ESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTP 1862
             .::.|||.|:|||||.||||.||||||||:|||||||||.|||:|.||||||||||||||||||
Frog  2205 TNNSIKLQLELIKTLEMLPIPNKNMLEESKILPIIQRWSQIKTAIPQLSEGDGYSSENTSRAHTP 2269

Human  1863 LNTP----DPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLD----- 1918
            ||||    :|:.|||.|||.:||||::.||||||||||||||:|||.||:|.||..|..:
Frog  2270 LNTPSNPTEPAAKLSVEADEETPKKIVLRRLKIISENSMDSAVSDAASEIEVKDVPEKTEVPSVV 2334

Human  1919 QLENVPV----EEEEELQSQQLLP-----------QQLPECKVDSETNIEASKLPTSEPEADAEI 1968
            :|::.|:    |.:|||:.:..:|           :|.|..|.:.:..::..||   ||   .:.
Frog  2335 ELKDAPLPKQEETKEELKPEGAVPPPVKEDPAATEEQKPIIKTEGDPGVDMCKL---EP---LDA 2393

Human  1969 EPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRI 2033
            |.||.||.||:|....|||||||||||||||||||||..||.:|:||||||||:|||||||||||
Frog  2394 EKKEGNGGKLDETSAVETPSQDEEEGVSDVESERSQEPADKILDMSDLATKLLESWKDLKEVYRI 2458

Human  2034 PKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYER 2098
            |||:|.|||  |.:|.||:.|....|  ||:..|.|:||.::|:|    ||||.|.|||  || .
Frog  2459 PKKTQVEKE--TNDRWRDSSGSTYTT--PKSQGRERDRDLERQSQ----RKRRQSPSPP--AY-Y 2512

Human  2099 GTKRPDD-RYDTP-TSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYD 2161
            |:||.:| ||||| :||||.|::||||||||||||||||||||:|||||||||||:|:.||:.|:
Frog  2513 GSKRVEDSRYDTPASSKKKSRLQDRNKLSTEERRKLFEQEVAQKEAQKQQQQMQNMGIASPMTYE 2577

Human  2162 SLGYNA--PHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEP 2224
            ::.|.|  |..||..||.|||:|::|||:||||||||||||.:|.:.||..:|.:|.:|   ..|
Frog  2578 AIAYGAQLPPPPFIAYPQGYPLQSFVDPTNPNAGKVLLPTPPLDGIPSPNSFDPSQGMV---VNP 2639

Human  2225 LSAPP-PVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSV 2288
            ...|| .|.||.|||||::|::.|||.|.:.:|.|:::|||||||||.||..|||.|||.|||:|
Frog  2640 GMMPPQTVSVVQHVAAPMDVTTQQYVTQGETMVPQETNVAVLPVPAPTPVPPQNYGVWDPNQQAV 2704

Human  2289 SV-------QQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFT 2346
            ::       |.||.||..||.||||||||..:|||.:.|:|..||:|.:|.|..||||.||||:.
Frog  2705 TLQPPQQQSQPQYPPAPPQAAIYYQGQTCQPMYGVPAAYAQPPPPVVPTYTQQGLQYITGQQIYA 2769

Human  2347 AHPQGVVVQPAAAVTTIVAPGQPQPLQPSEM-VVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPE 2410
            .||.|||:|...|||||||||||..:|..|| :..||:|||||||||||||||||..||||||||
Frog  2770 PHPPGVVLQQGPAVTTIVAPGQPPAMQQPEMGMAQNNVLDLPPPSPPKPKTIVLPSGWKTARDPE 2834

Human  2411 GKIYYYHVITRQTQWDPPTWESPGDD-ASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSEL 2474
            ||||||||||||||||||.|:|||:: .:||||||||||||||||||||:|||.|||||||||||
Frog  2835 GKIYYYHVITRQTQWDPPAWDSPGEEGGALEHEAEMDLGTPTYDENPMKSSKKTKTAEADTSSEL 2899

Human  2475 AKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLE 2539
            |||||||||||||||||||||||||||||:|||..|||||||||||||||||||||||||||||:
Frog  2900 AKKSKEVFRKEMSQFIVQCLNPYRKPDCKMGRINNTEDFKHLARKLTHGVMNKELKYCKNPEDLD 2964

Human  2540 CNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE 2572
            |||||||||||||||||||||.|||||||.::|
Frog  2965 CNENVKHKTKEYIKKYMQKFGTVYKPKEDIDIE 2997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SETD2	XP_011531934.1	AWS	1503..1557	CDD:197795	46/53 (87%)
		SET	1558..1681	CDD:214614	113/122 (93%)
		PostSET	1682..1698	CDD:214703	11/15 (73%)
		Asp-B-Hydro_N	<1948..2131	CDD:191249	110/184 (60%)
		WW	2399..2428	CDD:278809	26/28 (93%)
		SRI	2477..2556	CDD:285448	74/78 (95%)
setd2	XP_012820433.2	MSCRAMM_ClfB	<329..589	CDD:411414	145/264 (55%)
		ULP1	763..>1089	CDD:227489	45/325 (14%)
		PspC_subgroup_2	<960..1138	CDD:411408	13/184 (7%)
		AWS	1907..1961	CDD:197795	46/53 (87%)
		SET_SETD2	1961..2102	CDD:380949	127/140 (91%)
		WW	2823..2852	CDD:395320	26/28 (93%)
		SRI	2900..2988	CDD:400510	82/87 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	876	1.000	Domainoid score	I969
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56493
Inparanoid	1	1.050	1816	1.000	Inparanoid score	I881
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39523
OrthoDB	1	1.010	-	-		D11302at33208
OrthoFinder	1	1.000	-	-		FOG0002762
OrthoInspector	1	1.000	-	-		oto148336
Panther	1	1.100	-	-	LDO	PTHR46711
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080