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Protein Alignment GRIN2D and Nmdar1

DIOPT Version :9

Sequence 1:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	1024	Identity:	265/1024 - (25%)
Similarity:	437/1024 - (42%)	Gaps:	190/1024 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    82 LDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAP-ILDFLSAQTSLPIVAVH 145
            :|..|:..|.|          :||.|...||:.||...:..:..::| .:.:.|...|:|::.:.
  Fly    81 MDKNPIKTVFN----------VCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGIS 135

Human   146 GGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDG 210
            ...| ..:.|....:||:.......|..|..|:|..:.:|..:.:.:.....||.|...:..:..
  Fly   136 SRDA-AFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQT 199

Human   211 SLVGWEHRGALTL----DP---GAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGS 268
            .....:.|..:.|    :|   ...|.::  .:::..:::.|::.:.|:|:.:||.|.|..:||.
  Fly   200 YYDDVDVRATVELIVEFEPKLESFTEHLI--DMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGE 262

Human   269 GYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQA 333
            |:||.:....|....                .|.|:..::......|.. .:...|.|:|...:.
  Fly   263 GHVWIVTEQALFSNN----------------TPDGVLGLQLEHAHSDKG-HIRDSVYVLASAIKE 310

Human   334 LLRDYGFLPELGHDC--RAQNRTHRGESLHRYF--MNITWDNRDYSFNEDGFLVNPSLVVISLTR 394
            ::.: ..:.|...||  .|.| ...|:.|.:|.  .|||.:....:|:::|..:.....||::..
  Fly   311 MISN-ETIAEAPKDCGDSAVN-WESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIRE 373

Human   395 DRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQ---------HLTVATLEERPFVIVEPADP 450
            .:...|||.:...::|.|..:.......:.|....:         ||.:.|:||:|||.|.....
  Fly   374 QQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGD 438

Human   451 ISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK 515
            ....|..|..||....|      .||...| .||:|:|||:|..|:..|.|:|||.|..:|:.|.
  Fly   439 DEFRCEPDERPCPLFNN------SDATANE-FCCRGYCIDLLIELSKRINFTYDLALSPDGQFGH 496

Human   516 KI----DGV------WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG 570
            .|    .|.      |.|:|||:..:||||.:..||||.||:|.::||.||...||:::..:.:.
  Fly   497 YILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSR 561

Human   571 TVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWL 635
            :.:..:||:|:|..:|:::.| .:.|||:.:::.:..||.| ...|:...........:..::|.
  Fly   562 SSTLVSFLQPFSNTLWILVMV-SVHVVALVLYLLDRFSPFG-RFKLSHSDSNEEKALNLSSAVWF 624

Human   636 LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQR 700
            .|.::.|:.:....||..:::::.:|||.||:|.:||||||||||::.|.....:||::|.:.:.
  Fly   625 AWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRN 689

Human   701 PQEQYPPLKFGTVPNGSTEKNIRS--NYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVL 763
            ..|.   |...||...|.:...|.  ...:|:..|...|....|:|:..:|.|||.|||:|::.|
  Fly   690 TMEN---LTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRL 751

Human   764 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGIC 828
            .|.|.||  |:|||  :|::|..:||||.|.|||.|...:.||:|:|.....:|.|::.|   |.
  Fly   752 EYEASKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQW---IF 809

Human   829 HN------DKIEVMSSKLDIDNMAGVFYMLLV--AMGLSLLVFAWEHLVYWRLRHCLGPTHRMDF 885
            |.      :..|...:.|.:.||||||.::.|  |.|:.|::.   .::|  .:|.:....|:|.
  Fly   810 HGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIII---EVIY--KKHQVKKQKRLDI 869

Human   886 LLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRT---- 946
                                                              .|.:.|:||.|
  Fly   870 --------------------------------------------------ARHAADKWRGTIEKR 884

Human   947 -----------------KGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAA------ 988
                             .....||...||....||     |: ||..||..||.|..||
  Fly   885 KTIRASLAMQRQYNVGLNSTHAPGTISLAVDKRRY-----PR-LGQRLGPERAWPGDAADVLRIR 943

Human   989 -----GRPLSPP---AAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPS 1029
                 |.|...|   ||..|..|.| .....|.::...||..: ||:.|
  Fly   944 RPYELGNPGQSPKVMAANQPGMPMP-MLGKTRPQQSVLPPRYS-PGYTS 990

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.