Protein Alignment GRIN2A and Nmdar1

DIOPT Version :9

• Sequence 1: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Sequence 2: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Alignment Length: 1129
• Identity: 297/1129 - (26%)
• Similarity: 493/1129 - (43%)
• Gaps: 235/1129 - (20%)

Human    67 LLVWRGPAPSAAAEK-----GPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVV---- 122
            |||    ||..||::     .|...||..:|.:| |..|....|:      ..|..|...|
  Fly    19 LLV----APIDAAQRHTASDNPSTYNIGGVLSNS-DSEEHFSTTI------KHLNFDQQYVPRKV 72

Human   123 -----ALLMNRTDPKSLITHVCDLMSGARIHGLVFG-DDTDQEAVAQMLDFISSHTFVPILGIHG 181
                 .:.|:: :|...:.:|||.:...|::.:|.. :.|..:.....:.:.|....:|::|| .
  Fly    73 TYYDKTIRMDK-NPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGI-S 135

Human   182 GASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNS 246
            ......:||:...:|.:.......||.|.|:::..:.:....::.:.....|..:...:||....
  Fly   136 SRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTY 200

Human   247 FVGWDMQNVITLDTSFE---DAKTQ--VQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFF 306
            :...|::..:.|...||   ::.|:  :.:|...|.|.|:|.|.::|.:|..:|....:||....
  Fly   201 YDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHV 265

Human   307 WIV--PSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAK 369
            |||  .:|.|.||       |.|::.:..:. .:|.:..:||.:.:|.:|...|:.. ..|.||.
  Fly   266 WIVTEQALFSNNT-------PDGVLGLQLEH-AHSDKGHIRDSVYVLASAIKEMISN-ETIAEAP 321

Human   370 ASCYGQMERPEVPMHTLHPFMV--NVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWEN 432
            ..|.......|.... |..::.  |:|.:...::|.:.|.:::....||.:.:.::...|||:..
  Fly   322 KDCGDSAVNWESGKR-LFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSY 385

Human   433 HTLSLR--------HAVWP---RYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTV 486
            .::..:        ..:||   |.|......|  .||.::|:||.|||.|..:......|..:..
  Fly   386 DSMRAKMRMRINDSEIIWPGKQRRKPEGIMIP--THLRLLTIEEKPFVYVRRMGDDEFRCEPDER 448

Human   487 PCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV--NNV----- 544
            ||..|...:.:.||     .||:|:|||:|.:||:.:.|||||.|..:|:.|..:  ||.
  Fly   449 PCPLFNNSDATANE-----FCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTL 508

Human   545 ---WNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM---VSRSNGTVSPSAFLE 603
               |.|:|||:|.:||.|.|..||||.||:|.::||.||...||:::   .|||:..||   ||:
  Fly   509 RKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVS---FLQ 570

Human   604 PFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS-----FTIGKAIWLLWGL 663
            |||.::|:::.|.:.:| |:.:::.:.|||.|      :.|..|..|     ..:..|:|..||:
  Fly   571 PFSNTLWILVMVSVHVV-ALVLYLLDRFSPFG------RFKLSHSDSNEEKALNLSSAVWFAWGV 628

Human   664 VFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDY 728
            :.|:.:....|:..:::::..|||.||:|.:||||||||||::.|....:::|::|.:.:...:
  Fly   629 LLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME- 692

Human   729 SPPFRFGTVPNGSTERNIRNNYPYMHQY--MTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKA 791
              .....||...|.:...|......:.|  |...|....|.|:..:|.|||.|||:|::.|.|:|
  Fly   693 --NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEA 755

Human   792 GRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL-TGICHNE 855
            .:|  |:|||  :|.:|..:||||.|||||||...:.||:|:|...|.||:|:..|: .|  |.:
  Fly   756 SKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHG--HVQ 814

Human   856 KN----EVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSIS 916
            :|    |...:.|.:.||||||.::...:|                    .||     ||:
  Fly   815 QNCELFEKTPNTLGLKNMAGVFILVGVGIA--------------------GGV-----GLI---- 850

Human   917 RGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSPKRAADFIQRGS 981
              |...|:..|..:|:|                                |:|..:.||| ..||:
  Fly   851 --IIEVIYKKHQVKKQK--------------------------------RLDIARHAAD-KWRGT 880

Human   982 LIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESN-P 1045
            :                                      .::|....:...|.|:.:.||.:: |
  Fly   881 I--------------------------------------EKRKTIRASLAMQRQYNVGLNSTHAP 907

Human  1046 NTVEVAVSTE--SKANSR--PRQLW---KKSVDSIRQDSLSQNPVSQRDEATAENR--------- 1094
            .|:.:||...  .:...|  |.:.|   ...|..||:.....|| .|..:..|.|:
  Fly   908 GTISLAVDKRRYPRLGQRLGPERAWPGDAADVLRIRRPYELGNP-GQSPKVMAANQPGMPMPMLG 971

Human  1095 ----THSLKSPRYLPEEMAHSDIS 1114
                ..|:..|||.|...  ||:|
  Fly   972 KTRPQQSVLPPRYSPGYT--SDVS 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIN2A	XP_016878661.1	None
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	87/408 (21%)
		ANF_receptor	58..371	CDD:279440	68/330 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	154/426 (36%)
		HisJ	451..>558	CDD:223904	45/111 (41%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	48/144 (33%)
		Lig_chan	575..838	CDD:278489	94/278 (34%)
		CaM_bdg_C0	854..882	CDD:287524	11/98 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910