DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIN1 and Nmdar1

DIOPT Version :9

Sequence 1:	XP_005266130.1	Gene:	GRIN1 / 2902	HGNCID:	4584	Length:	959	Species:	Homo sapiens
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	954	Identity:	437/954 - (45%)
Similarity:	618/954 - (64%)	Gaps:	67/954 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    20 AACDPKIVNIGAVLSTRKHEQMFREAVNQAN--KRHGSWKIQLNATSVTHKPNAIQMALSVCEDL 82
            |:.:|...|||.|||....|:.|...:...|  :::...|:.....::....|.|:...:||:.|
  Fly    32 ASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKL 96

Human    83 ISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQ 147
            |.::|||::|||..|..| .:|..||||:|||.|||:|:::|.:.:|||:||:|||||||||.||
  Fly    97 IENRVYAVVVSHEQTSGD-LSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQ 160

Human   148 SSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKRGPKA 212
            :.||.||:..:::..:|::.|.|.:|||...|.:|        :.:..|:::|..:       ..
  Fly   161 ADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQT--------TSQTYYDDVDVRA-------TV 210

Human   213 EKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 277
            |.:::|:|..::.|..|::.|..::||.::.||.:||..::|.|...||||.|:||:|.|:.:..
  Fly   211 ELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS 275

Human   278 NALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLF 342
            |   ..|||:|||||.:..::..||.|:|.|:|.|:.|::..|.|.:.|:.|..:...|::|
  Fly   276 N---NTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESG--- 334

Human   343 KRVL--MSSKYADGVTGRVEFNEDGDRKFANYSIMNL--QNRKLVQVGIYN------GTHVIPND 397
            ||:.  :.|:...|.||:|.|:::|||.:|.|.::|:  |.:|.| ||.::      ...:..||
  Fly   335 KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV-VGKFSYDSMRAKMRMRIND 398

Human   398 RKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGD--PVKKVICTGP 460
            .:|||||.:..||.|..:.|.|:::||.::|||||: .:.|    :||....|  |     |...
  Fly   399 SEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVR-RMGD----DEFRCEPDERP-----CPLF 453

Human   461 NDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSN----KKEWNG 521
            |::...:...    ||.|:||||||:|::.:||||::.|..||:||.....||:.    :|||.|
  Fly   454 NNSDATANEF----CCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTG 514

Human   522 MMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLL 586
            ::|||::.:|||||||||||.|||:||||||||||||:|||.||....|||.||:|||.:|||:|
  Fly   515 LIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWIL 579

Human   587 VGLSVHVVAVMLYLLDRFSPFGRFKV-NSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSA 650
            |.:||||||::||||||||||||||: :|:..||.||.||||:||:||||||||||||.||||||
  Fly   580 VMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSA 644

Human   651 RILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR 715
            |:||||||||||||||||||||||||||:||:.:::||||.||||..:....||||.||||:|||
  Fly   645 RVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFR 709

Human   716 RQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFG 780
            ||||||.|||.||.:||.:|.:|||.|:..||.||||||:.||:|||:.|:|||.||||.|||:|
  Fly   710 RQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYG 774

Human   781 IGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRY----QECDSRSNAPATLTFENMAGVFMLV 841
            ||::|.|||...|:|:||:.||:||||.|||.|:.:    |.|:.....|.||..:||||||:||
  Fly   775 IGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILV 839

Human   842 AGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKK------AT 900
            ..||..|:.||.||:.||:|:..::|::.:|..|.:.||..::.||:.||....:::      :|
  Fly   840 GVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNST 904

Human   901 FRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIE 944
            ....|.:||.. |||........|..|....:..|.:..||..|
  Fly   905 HAPGTISLAVD-KRRYPRLGQRLGPERAWPGDAADVLRIRRPYE 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIN1	XP_005266130.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	137/390 (35%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	249/414 (60%)
		CaM_bdg_C0	856..884	CDD:402271	8/27 (30%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	139/395 (35%)
		ANF_receptor	58..371	CDD:279440	118/334 (35%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	249/414 (60%)
		HisJ	451..>558	CDD:223904	58/110 (53%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	100/134 (75%)
		Lig_chan	575..838	CDD:278489	176/262 (67%)
		CaM_bdg_C0	854..882	CDD:287524	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141595
Domainoid	1	1.000	356	1.000	Domainoid score	I990
eggNOG	1	0.900	-	-		E1_KOG4440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7187
Inparanoid	1	1.050	776	1.000	Inparanoid score	I529
Isobase	1	0.950	-	0	Normalized mean entropy	S4386
OMA	1	1.010	-	-		QHG49285
OrthoDB	1	1.010	-	-		D108757at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		oto89474
orthoMCL	1	0.900	-	-		OOG6_107231
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4690
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.790