Protein Alignment GRIK5 and Ir75b

DIOPT Version :10

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 154/675 - (22%)
• Similarity: 258/675 - (38%)
• Gaps: 148/675 - (21%)

Human   210 KVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVED---SSNILGFSMFN 271
            |:|.::| .:.|:|||.|...|         |.|.|  .|..||.|..:.|   :.|||...:|
  Fly    17 KLSHVLI-LHCSLSHLALLAQS---------KNIFT--QFQPLHSDIQLNDDFLNHNILKLGVF- 68

Human   272 TSHPFYPEFVRSLNMSWRENCEAS-TYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACT 335
                        |::    ||:.| |.|..|.:........|.::     .:||....|......
  Fly    69 ------------LDI----NCDKSGTVLDMASAKRFFSHRYHWLI-----YDRSMNFSVLESHFK 112

Human   336 SANIW--------PHGTSLMNYLRMVEYDGLTGRV---EFNSKGQR------TN-----YTLRIL 378
            .|.|:        .|.....|:|....|:  .||.   |.|....|      ||     |...:.
  Fly   113 EAQIFVDADVTYVTHDPFSKNFLLYDVYN--KGRQLGGELNITADREIFCNKTNCRVERYLSELY 175

Human   379 EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERF 443
            .:|...||:.....:.|..|: .|.|.:|:|      ...:...:.:.|.::...:..|....|
  Fly   176 TRSALQHRKSFTGLTMRATAV-VTALPLNVS------IKEIFDFMNSKYRIQLDTYARLGYQAR- 232

Human   444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWT------GMVGELINRQKADLAVAAFT 502
                 ..||::.: .:|:|..|             ..|:      ||:|:|| ..|||||:|.|.
  Fly   233 -----QPLRDMLD-CKFKYIFR-------------DRWSDGNATGGMIGDLI-LDKADLAIAPFI 277

Human   503 ITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS-------FLDPFSPAVWLFMLLAYLAVSC 560
            .:.:|..   |.:|...  .|:...:.|.|.|...|       ||.|||..|||...|..|...|
  Fly   278 YSFDRAL---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGC 337

Human   561 VLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW 625
            :|::...|...:.:.|               :|..|.....|....||:.:.||::..|
  Fly   338 LLWVTFILERRKQWKP---------------SLLTSCLLSFGAGCIQGAWLTPRSMGGR------ 381

Human   626 WAFTLIIISS------YTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRY 684
            .||..::::|      ||:.:.:.|..|.::..:.:...||| :|::.|......|..:.:.|..
  Fly   382 MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLAD-SNLDVGIEPTVYTRIYVETSEE 445

Human   685 QTYQRMW--NYMQSKQ-PSVFVKSTEEGIARVLNSR-YAFLL-ESTMNEYHRR-----LNCNLTQ 739
            ...:.::  ..:.||: |......||.|:..|.:.. :.::. .:|..|:.|:     ..|.|.:
  Fly   446 PDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNE 510

Human   740 IGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMEN 804
            | .|.|.......:...||:.:.|.|:.|::.|.......:|.|.|......:.:|.. .:|:|.
  Fly   511 I-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEY 573

Human   805 IGGIFIVLICGLIIAVFVAVMEFIW 829
            ...:||:|:..:|:.:.:..:|.||
  Fly   574 AAPLFIILLGAIILCMGILGLEVIW 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	51/216 (24%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	88/399 (22%)
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	18/62 (29%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	25/71 (35%)
		Lig_chan	343..584	CDD:459656	54/264 (20%)