Protein Alignment GRIK5 and Ir75b

DIOPT Version :9

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 154/675 - (22%)
• Similarity: 258/675 - (38%)
• Gaps: 148/675 - (21%)

Human   210 KVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVED---SSNILGFSMFN 271
            |:|.::| .:.|:|||.|...|         |.|.|  .|..||.|..:.|   :.|||...:|
  Fly    17 KLSHVLI-LHCSLSHLALLAQS---------KNIFT--QFQPLHSDIQLNDDFLNHNILKLGVF- 68

Human   272 TSHPFYPEFVRSLNMSWRENCEAS-TYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACT 335
                        |::    ||:.| |.|..|.:........|.::     .:||....|......
  Fly    69 ------------LDI----NCDKSGTVLDMASAKRFFSHRYHWLI-----YDRSMNFSVLESHFK 112

Human   336 SANIW--------PHGTSLMNYLRMVEYDGLTGRV---EFNSKGQR------TN-----YTLRIL 378
            .|.|:        .|.....|:|....|:  .||.   |.|....|      ||     |...:.
  Fly   113 EAQIFVDADVTYVTHDPFSKNFLLYDVYN--KGRQLGGELNITADREIFCNKTNCRVERYLSELY 175

Human   379 EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERF 443
            .:|...||:.....:.|..|: .|.|.:|:|      ...:...:.:.|.::...:..|....|
  Fly   176 TRSALQHRKSFTGLTMRATAV-VTALPLNVS------IKEIFDFMNSKYRIQLDTYARLGYQAR- 232

Human   444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWT------GMVGELINRQKADLAVAAFT 502
                 ..||::.: .:|:|..|             ..|:      ||:|:|| ..|||||:|.|.
  Fly   233 -----QPLRDMLD-CKFKYIFR-------------DRWSDGNATGGMIGDLI-LDKADLAIAPFI 277

Human   503 ITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS-------FLDPFSPAVWLFMLLAYLAVSC 560
            .:.:|..   |.:|...  .|:...:.|.|.|...|       ||.|||..|||...|..|...|
  Fly   278 YSFDRAL---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGC 337

Human   561 VLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW 625
            :|::...|...:.:.|               :|..|.....|....||:.:.||::..|
  Fly   338 LLWVTFILERRKQWKP---------------SLLTSCLLSFGAGCIQGAWLTPRSMGGR------ 381

Human   626 WAFTLIIISS------YTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRY 684
            .||..::::|      ||:.:.:.|..|.::..:.:...||| :|::.|......|..:.:.|..
  Fly   382 MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLAD-SNLDVGIEPTVYTRIYVETSEE 445

Human   685 QTYQRMW--NYMQSKQ-PSVFVKSTEEGIARVLNSR-YAFLL-ESTMNEYHRR-----LNCNLTQ 739
            ...:.::  ..:.||: |......||.|:..|.:.. :.::. .:|..|:.|:     ..|.|.:
  Fly   446 PDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNE 510

Human   740 IGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMEN 804
            | .|.|.......:...||:.:.|.|:.|::.|.......:|.|.|......:.:|.. .:|:|.
  Fly   511 I-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEY 573

Human   805 IGGIFIVLICGLIIAVFVAVMEFIW 829
            ...:||:|:..:|:.:.:..:|.||
  Fly   574 AAPLFIILLGAIILCMGILGLEVIW 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	50/214 (23%)
		ANF_receptor	42..379	CDD:279440	46/194 (24%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	88/399 (22%)
		Lig_chan	546..816	CDD:278489	61/285 (21%)
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	78/328 (24%)
		Lig_chan	343..585	CDD:278489	54/265 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840