Protein Alignment GRIK5 and Ir7f

DIOPT Version :9

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001138177.1
• Gene: Ir7f / 7354418
• FlyBaseID: FBgn0259188
• Length: 621
• Species: Drosophila melanogaster
• Alignment Length: 700
• Identity: 132/700 - (18%)
• Similarity: 236/700 - (33%)
• Gaps: 214/700 - (30%)

Human   216 IDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEF 280
            ||.....::|.:.:|..|.:.:...: :.||:         :|..|:..||     |:|.|  |:
  Fly    31 IDMQGEDANLYVARALRLVIENVLAQ-LSTTL---------VVTISTRHLG-----TAHWF--EY 78

Human   281 VRSLNM-SWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGT 344
            :.::.| |||                         :.||:.|....::.|.|:.         |.
  Fly    79 MMNILMDSWR-------------------------MVAVQLLRIRPDLVVNPVP---------GR 109

Human   345 SLMNYLRMVEYDGL--TGRVEFNSKGQRTNYTL-------RILEKSRQ---GHREIGVWYSNRTL 397
            ..::.|.:..|.||  |.....|:.....:|..       .::.|..|   .|.....|.....:
  Fly   110 KRVSLLMVDSYQGLLDTNITASNANFDDPDYYFIFLQARDHLIPKELQLILDHCLAHFWLHCNVM 174

Human   398 AMNATT--------------------LDIN--------LSQTLANK-------TLVVTTILENPY 427
            ...|..                    :.:|        .||...:|       .|.|.|..:.|:
  Fly   175 IQTAQVEVLVYTYYPYTADACQKAYPIPVNTFDGRKWKASQMFPDKLSQMHGCPLTVLTWHQPPF 239

Human   428 V--MRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPN------GSWTGM 484
            |  :..|......|:    ||.:.::..||.  |..:.|.||...|.   .||      ||..|.
  Fly   240 VELVWDPKHNRSRGS----GFEIQLVEHLAR--RMNFSLELVNIALL---RPNAYRLAEGSSEGP 295

Human   485 VGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWL 549
            :.:|:.| ..::::..|..||.|.:::.....:.:..:..:.::...|.......:.||..:||:
  Fly   296 IEKLLQR-NVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVWM 359

Human   550 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQ-----QGS 609
            .:|||.|     :.|...|         |..|.           ||.  ...||.:|     .|:
  Fly   360 LLLLALL-----IHLGIHL---------PSARR-----------GNE--EDGGGGLQVVALLLGA 397

Human   610 EI--MPRALSTRCVSGVW-WAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIH 671
            .:  :||:...|.::..| || ::.:..||.:.|...:.:|....|..|.|.|..:.
  Fly   398 ALARLPRSWRHRFIAAHWLWA-SIPLRISYQSLLFHLIRLQLYNTPSFSLDQLLAEG-------- 453

Human   672 AGSTMTFFQNSRYQTYQRM----------------------WNYMQSKQPSVFVKSTEEGIARVL 714
                   ||.......||:                      |:.:     :|..::....|..|.
  Fly   454 -------FQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVL-----NVLTRNRNRKIFAVA 506

Human   715 NS--RYAFLLEST-MNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRL 776
            |.  ..:||..|. .|.:|        .:...::.:..|:.||..|...:::...|.:|..:..:
  Fly   507 NQDVTLSFLHSSAHPNAFH--------VVKQPVNVEYAGMYMPKHSFLYEKMDDDIRRLDASGFI 563

Human   777 EILKRKWWEGGRCPKEEDHRA--KGLGMENIGGIFIV-----LICGLIIA 819
            ...:|..:.... .||:.|..  :.:....:.||::|     |:.||:.|
  Fly   564 HAWRRASFASVH-RKEQVHMTSRRYINHAKLSGIYMVMAGLYLLAGLLFA 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	36/195 (18%)
		ANF_receptor	42..379	CDD:279440	32/172 (19%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	82/418 (20%)
		Lig_chan	546..816	CDD:278489	58/309 (19%)
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	29/136 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910