Protein Alignment GRIK5 and Ir7e

DIOPT Version :9

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001138176.1
• Gene: Ir7e / 7354417
• FlyBaseID: FBgn0259189
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 116/689 - (16%)
• Similarity: 218/689 - (31%)
• Gaps: 243/689 - (35%)

Human   284 LNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVREL---------------NRS-----QEIG 328
            ||..:..:.|...::...::.|::....|.::|....|               |:.     :|.|
  Fly     7 LNSYYDLSGEQMNHINEFVARAVLHVVHHYILSVTPSLVLTLCCRSNHTCNFYNKMMSTLFREWG 71

Human   329 VKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFN----------------SKGQRTNYT--- 374
            :.||            .::|.||.|.:..:.||..||                ...:..||.
  Fly    72 LAPL------------QIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHY 124

Human   375 ---LRILEKSRQG---------------HREIGVWYSNRTLAM---------NATTLDINLSQTL 412
               |:..::..||               |..|.|..||..:..         ..:.::..|....
  Fly   125 FIFLQARDRLLQGEMRLIFDYCWRYRLIHCSIQVQKSNGDILFYSYYPFGEHGCSDMEPQLINRY 189

Human   413 ANKTLVVTTILENPYVMRR-------------PNF--------QALSGNERFEGFCVDMLRELAE 456
            ....||...:.  |..:|.             |.|        :.|..|..:||   .:|..|||
  Fly   190 NGSMLVEPDLF--PRKLRNFFGCPLRCALWDVPPFLTLDEDQEEVLRVNGGYEG---RLLLALAE 249

Human   457 LLRFRYRLRLV-----EDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKP 516
            .:.|...:|.|     ::.|               |::.|.:.||.:.....|..|..|...|
  Fly   250 KMNFTIAVRKVHVNMRDEAL---------------EMLRRDEVDLTLGGIRQTVARGMVATSS-- 297

Human   517 FMTLGISILYRVHMGRK------PGY-FSFLD----PFSPAVWLFMLLAYLAVSCVL-FLAARLS 569
                     :..|..|:      ..| .|..|    |:...:|: .:|..:|:|.:: .:..|:
  Fly   298 ---------HNYHQTREVFGVLASSYELSSFDILFYPYRLQIWM-GILGVVALSALIQLIVGRM- 351

Human   570 PYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM--PRALSTRCVSGVWWAFTLII 632
                      ||.|         :|:..|..: ..:..|..::  ||:.:.|....:...:||||
  Fly   352 ----------LRER---------MGSRFWLNL-ELVFVGMPLLECPRSHTARLYCVMLMMYTLII 396

Human   633 ISSYTANLAAFLTVQRME------------------VPV--ESADDLADQTNIEYGTIHAGSTM- 676
            .:.|...|...:...::.                  .|:  |..|::....::.:..:.|.|.:
  Fly   397 RTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSELD 461

Human   677 -TFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQI 740
             .:|..:.:|..|    ::.:....:|:                         :..||:.:....
  Fly   462 PLYFLEANHQLRQ----HVTASALDIFI-------------------------HFNRLSADKVHQ 497

Human   741 GGLLDTKGYG----------IGMPL------GSPFRDEITLAILQLQENNRLEILKRKWWEGGRC 789
            .|   .:|.|          |.|.|      .|...|::...|:.::....|.:..|  ||....
  Fly   498 RG---EQGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGLLSVWSR--WELSES 557

Human   790 PKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI 828
            ....:...:.||...:..||::::.|||:.:.|.::|.:
  Fly   558 YLRNEQSFQVLGTMELYAIFLMVLVGLIVGLLVFILELV 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	30/171 (18%)
		ANF_receptor	42..379	CDD:279440	23/136 (17%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	74/448 (17%)
		Lig_chan	546..816	CDD:278489	48/310 (15%)
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	24/123 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840