Protein Alignment GRIK5 and GluRIB

DIOPT Version :10

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1128
• Identity: 350/1128 - (31%)
• Similarity: 531/1128 - (47%)
• Gaps: 261/1128 - (23%)

Human    14 ASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK-----ARVEV----DIFE 69
            |.||  :...:.:.||.:..|     :.:..|.....:|..:.|.::     |.|:|    |.|:
  Fly    34 AQPS--LTEKIPLGAIFEQGT-----DEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFK 91

Human    70 LQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYL 131
            |.|        .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  ||...:|
  Fly    92 LSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFL 147

Human   132 RFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDS 196
            .|| :|:.|   |...|:...::.:.:.....:....:.||||:::.:|.....|:..|.::...
  Fly   148 DFA-LSMRP---DYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRI 208

Human   197 RDPT------PLLKEIRDDKVSTIIIDANASIS-HLILRKASELGMTSAFYKYILTTMDFPILHL 254
            .:.:      ..|::|...:...|::|....:: .::::...:|.:....|.|:|:
  Fly   209 SNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLS--------- 264

Human   255 DGIVED-----------SSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALS----- 303
             |:|.|           :.||.||.:.:|:.    ..||....||:.       |.|.:|
  Fly   265 -GLVMDDRWESEIIEFGAINITGFRIVDTNR----RLVREFYDSWKR-------LDPQMSVGAGR 317

Human   304 ------AALMFDAVHVVVSAVREL-------------NRSQEIGV-------------------- 329
                  ||||:|||.|:|.|..::             .|||.:.|
  Fly   318 ESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGG 382

Human   330 -----------------------KPLACTSA----NIWPHGTSLMNYLRMVEYDGLTGRVEFNSK 367
                                   :.|.|.:|    |.|.||..:..|||.||.:||||.::||..
  Fly   383 GGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDD 447

Human   368 GQRTNYTLRILEKS-RQGHREIGVWYSNRTL-AMNATTLDINLS-QTLANKTLVVTTILENPYVM 429
            |:|.||||.::|.: .....::..|..:..| .:||..:.:... :...|:|.:|||:||.||:|
  Fly   448 GRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIM 512

Human   430 -RRPNF-QALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPE--PNGSWTGMVGELIN 490
             ::..| :.|.||.||||:|.|:...||:.|...|.||||:||.||:.:  .:|.|.||||||:
  Fly   513 LKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELV- 576

Human   491 RQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAY 555
            |::||:|:||.|||||||:|||||||||:|||||:.:..:.:.||.|||::|.|..:|:.::.:|
  Fly   577 RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSY 641

Human   556 LAVSCVLFLAARLSPYEW----YNPHPCLRARPH------------------------------- 585
            :.||.|||..:|.||:||    ..|.......||
  Fly   642 IGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGA 706

Human   586 -------------------------ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW 625
                                     .:.|::::.||.||.:..|||||.::.||::|.|..:..|
  Fly   707 QTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASW 771

Human   626 WAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRM 690
            :.||||:||||||||||||||:||..|:.|.:|||.||.::|||:..|||..||:.|:...:.:|
  Fly   772 FFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKM 836

Human   691 WNYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIG 752
            |.||.|:: .|||.:.:|||.||.||  :||.|:||..||| :.|..|:..::|..|||||:||.
  Fly   837 WEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIA 900

Human   753 MPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCPKEEDHRA--KGLGMENIGGIFIVLIC 814
            .||||..:|.|.||:|.|:||..|..|:.||| |...|...:|...  ..|.:.|:.|||.:||.
  Fly   901 TPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIG 965

Human   815 GLIIAVFVAVMEFIWSTR--RSAESEETPALH---PAACQCSALGPRTPLKEPSMLLVKVPSTRV 874
            ||:::||||::|:.:.:|  |||.|.....|.   .......:||.    ...||:|  .||:.|
  Fly   966 GLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGK----ANGSMML--GPSSAV 1024

Human   875 QVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCHFSSLKPSPDLTFPPSHRPLSSLLFTALA 939
            ......:           ||.|:|             ..::.....||...| |...:      .
  Fly  1025 PGGMPSS-----------HQRSTL-------------TDTMHAKAKLTIQAS-RDYDN------G 1058

Human   940 AVGGLPDASSFFFPP--ISSCPP 960
            .||.|..||..::||  :|:.||
  Fly  1059 RVGYLNCASLQYYPPAQLSATPP 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	106/480 (22%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	190/438 (43%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	106/475 (22%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	191/442 (43%)
		Lig_chan	630..966	CDD:459656	127/336 (38%)