DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK5 and Ir93a

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	964	Identity:	196/964 - (20%)
Similarity:	359/964 - (37%)	Gaps:	248/964 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     2 PAELLLL--------LIVAFASPSCQVLS-SLRMAAILDDQTVCGRGERLALALAREQINGII-E 56
            |:..|||        |:...|:.....|| :..:|.::|.:.:...||.: ||...:.::.:| |
  Fly     8 PSACLLLLAGLQLSILVPTEANDFSSFLSANASLAVVVDHEYMTVHGENI-LAHFEKILSDVIRE 71

Human    57 VPAKARVEVDIF-----ELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKE-- 114
            ......:.|..|     .|::|.....|.|.|:                   :|.:.....:|
  Fly    72 NLRNGGINVKYFSWNAVRLKKDFLAAITVTDCE-------------------NTWNFYKNTQETS 117

Human   115 IPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAV--SRILKSFNYPSASLICAKAECLLRLEE- 176
            |..|.:...:.|||...|...|.:..:.::....:  :::.:..|:.:|.:...:.    .|||
  Fly   118 ILLIAITDSDCPRLPLNRALMVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQT----ILEEN 178

Human   177 --LVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASI----SHLILRKA----- 230
              ||:..:....|..:         ||         :|.|:.:.|.|:    ..:.||:|
  Fly   179 ALLVKSIVHESITNHI---------TP---------ISLILYEINDSLRGQQKRVALRQALSQFA 225

Human   231 --------SELGMTSAFYKYILTTMD----------FPILHLDGIVED------------SSNIL 265
                    .:..:.|||::.|:...:          :.|..||.:..|            .:||
  Fly   226 PKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDEGANI- 289

Human   266 GFSMFNTSHPFYPEFVRSLNMSWRENC---EASTYLGPALS-AALMFDAVHVVVS-----AVREL 321
            .|::..|.    |....||      ||   |.|..|..|:| ..:..::::..:|     |:|..
  Fly   290 AFALNETD----PNCQDSL------NCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFT 344

Human   322 NRSQEIGV--------KPLA-CTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRI 377
            .:.::..:        |..| |:|...|...|::           ..|:.:.|.|.:.|...
  Fly   345 KQEKQAEILEYMKEFLKTNAKCSSCARWRVETAI-----------TWGKSQENRKFRSTPQR--- 395

Human   378 LEKSRQGHREIGVWYSNRTLAMNATTLDI-NLSQTLANKTLVVTTILENPYVMRRPNFQALSGNE 441
             :...:....|.:.|....|......|.. ::.....|.|:.:.|:       ..|.:|.|:.|.
  Fly   396 -DAKNRNFEFINIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTV-------HNPPWQILTKNS 452

Human   442 -----RFEGFCVDMLRELAELLRFRYRLRLV-----EDGLYGAPEPN------GSWT----GMVG 486
                 ..:|..:::::||:..|.|.|.|...     ||.|..:...|      ||.|    ..|.
  Fly   453 NGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVV 517

Human   487 ELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS----FLDPFSPAV 547
            |::...:..:|..|.|:....:|..::::|     ||:.....:.|||...|    |..||:...
  Fly   518 EMVQGNQFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSFITRKPDEVSRIYLFTAPFTVET 577

Human   548 WLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM 612
            |..::...|..:..|:...||:|.:...           :....|:.:..|:..|..:|||...:
  Fly   578 WFCLMGIILLTAPTLYAINRLAPLKEMR-----------IVGLSTVKSCFWYIFGALLQQGGMYL 631

Human   613 PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNI-EYGTIHAGSTM 676
            |.|.|.|.|.|.||...::::::|..||.||||..:.:..|:..:.|.|..:| :||..:.
  Fly   632 PTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNG---- 692

Human   677 TFFQNSRY---QTYQRMWNYMQSKQPSVFVKSTEEGIARV-----LNSRYAFLLE-STMNEYHRR 732
            |||:  ||   .|.:...:|::  :..::..:.||.|..|     :|..:...|: .....:.|.
  Fly   693 TFFE--RYVQSTTREDFKHYLE--RAKIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFERE 753

Human   733 LNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQE------NNRLEILKR-----KWWE- 785
            ..|:            :.:|.   ..|.||....|:..|.      |..::.:.|     :|.:
  Fly   754 KECH------------FALGR---ESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQM 803

Human   786 ----GGRCPKEEDHRA---KGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTR 832
                .|:|..:...|.   ..:.|:::.|.|:||:.|..:|:.:...|| |..|
  Fly   804 NLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEF-WYRR 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	79/443 (18%)
		ANF_receptor	42..379	CDD:279440	72/406 (18%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	94/415 (23%)
		Lig_chan	546..816	CDD:278489	65/298 (22%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	73/296 (25%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	63/293 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156010
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840