DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GRIK5 and Ir92a

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_001097845.2	Gene:	Ir92a / 42415	FlyBaseID:	FBgn0038789	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	102/505 - (20%)
Similarity:	175/505 - (34%)	Gaps:	129/505 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   394 NRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRR----------------PNFQALSGNER 442
            |.|.| |...|..|....|..::|:|.:|...||.:..                || ::|:
  Fly   225 NETFA-NRVELYPNKLLNLQRRSLLVGSITYVPYTITNYVPAGQGDVDPIHPQWPN-RSLT---- 283

Human   443 FEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAER 507
            |:|...::::...::.....|:.......:|....|.|..||:|: |..|:.::|:..  |....
  Fly   284 FDGAEANVMKTFCQVHNCHLRVEAYGADNWGGIYDNESSDGMLGD-IYEQRVEMAIGC--IYNWY 345

Human   508 EKVIDFSKPFMTLGISILYRVHMGRK----PGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARL 568
            :.:.:.|.......::||     |..    |.:.:.:.||:...|| :|::.|.: |..||
  Fly   346 DGITETSHTIARSSVTIL-----GPAPAPLPSWRTNIMPFNNRAWL-VLISTLVI-CGTFL---- 399

Human   569 SPYEWYNPHPCLRARPHILENQY----TLGNSLWFPVGGFMQQGS------EIMPRALSTRCVSG 623
                ::..:...|.|....:.::    .|..|:......|:||.|      ...||......:..
  Fly   400 ----YFMKYVSYRLRYSGTQVKFHHSRKLEKSMLDIFALFIQQPSAPLSFDRFAPRFFLATILCA 460

Human   624 VWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQ 688
                 |:.:.:.|:..|.:.||......||::.:..|                           |
  Fly   461 -----TITLENIYSGQLKSMLTFPFYSAPVDTIEKWA---------------------------Q 493

Human   689 RMWNYMQSKQPSVF----VKS----TEEGIARVLNSR-YAFLLE-STMNEYH---RRLNCNLTQI 740
            ..|.:   ..||:.    |:|    ||:.:||..... |::|.. |.|..|.   .||:.....:
  Fly   494 SGWKW---SAPSIIWVHTVQSSDLETEQILARNFEVHDYSYLSNVSFMPNYGFGIERLSSGSLSV 555

Human   741 GGLLDTKGYGIGMPLGSPFRDEITLA------ILQLQENNRLEILKRK----WWEGGRCPKEED- 794
            |..:.|:.....:.|......:.|.|      ||..:.|..:...:..    .||.....|..|
  Fly   556 GDYVSTEALENRIVLHDDLYFDYTRAVSIRGWILMPELNKHIRTCQETGLYFHWELEFIDKYMDK 620

Human   795 ------------HRAKG----LGMENIGGIFIVLICGLIIAVFVAVMEFI 828
                        |:.||    |.:.||.|...||..|:..|....|.|.:
  Fly   621 KKQEVLMDLANGHKVKGAPQALDVRNIAGALFVLAFGVAFAGCALVAELL 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	2/4 (50%)
		ANF_receptor	42..379	CDD:279440
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	78/423 (18%)
		Lig_chan	546..816	CDD:278489	63/319 (20%)
Ir92a	NP_001097845.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840