DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GRIK5 and Ir85a

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	337	Identity:	70/337 - (20%)
Similarity:	113/337 - (33%)	Gaps:	98/337 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    24 LRMAAILDD--------QTVCGRGERLALALAREQING--------------------IIEVPAK 60
            |||....||        .|:.|....|| |...|::|.                    .:|| ||
  Fly   206 LRMCIYKDDVRAIFWRQGTILGTDGLLA-AYVAERLNATMMITRPHSYNNHNLSSDICFLEV-AK 268

Human    61 ARVEV---------DIFELQRDSQY-ETTDTMCQILPKG---------------------VVSVL 94
            ..|:|         |.|..|.:|.. .|.|.:|.|:||.                     :||||
  Fly   269 EYVDVAMNIRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGSLVWALILVSVL 333

Human    95 GPS------SSPASASTVSHICGEKEIPHIKVGPEETPRL-----QYLRFASVSLYPSNEDVSLA 148
            ..:      .|......:....|...:|..::.|..:.||     .|......|.:..|....:.
  Fly   334 VANVFCYILKSEVGRVPMQLFAGALTMPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLTSMMV 398

Human   149 VSRILKSFNYPSASLICAKAECLLRLEEL--VRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKV 211
            ....|...|...| |..:....::|...:  ::.||    ||..:  .:||....:| |:.|.::
  Fly   399 FQPYLPDINQLGA-LARSHYHIIIRPRHVKHIQHFL----TLGHK--HESRIREQML-EVSDTQM 455

Human   212 STIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDG----------IVEDSSNILG 266
            ..::.:.:...::|.....:...:.|..:.:    :..|:.||..          ||...|..||
  Fly   456 YEMMRNNDIRFAYLEKYHIARFQVNSRVHMH----LGRPLFHLMNSCLVPFHAVYIVPYGSPYLG 516

Human   267 F--SMFNTSHPF 276
            |  |:..:||.|
  Fly   517 FLDSLIRSSHEF 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	69/336 (21%)
		ANF_receptor	42..379	CDD:279440	63/311 (20%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360
		Lig_chan	546..816	CDD:278489
Ir85a	NP_649833.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840